Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Compound eye  (5)
  • Morphine  (5)
  • Blood-brain barrier  (3)
  • Cell & Developmental Biology  (3)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Asymmetrical effects of morphine and naloxone on reward mechanisms (1982)
    Springer
    Psychopharmacology 78 (1982), S. 219-224 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Naloxone ; Cerebral asymmetry ; Self stimulation ; Rotation ; Reinforcement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats with bilaterally implanted lateral hypothalamic electrodes were tested daily for self-stimulation to each side of the brain, and rotation (circling behavior) was recorded concomitantly. All rats rotated in a preferred direction regardless of the side of the brain stimulated and all rats had asymmetries in self-stimulation sensitivity related to the direction of rotation. Morphine increased rotation and lowered self-stimulation thresholds at low doses (e.g., 2.5 mg/kg) and decreased rotation and raised self-stimulation thresholds at high doses (e.g., 20.0 mg/kg). The changes in self-stimulation thresholds preferentially occurred on opposite sides of the brain, i.e., the low-dose decrease in thresholds was greater in the normally less sensitive side of the brain whereas the high-dose increase in thresholds was greater in the normally more sensitive side of the brain. Naloxone produced no changes in rates of rotation but did elicit small changes in self-stimulation that varied with the side of the brain, i.e., dose-related decreases in thresholds occurred in the normally more sensitive side of the brain whereas dose-related increases in thresholds occurred in the normally less sensitive side of the brain. Subsequently rats were tested in a choice procedure providing concurrent access to rewarding stimulation of either side of the brain; currents were titrated such that, under baseline conditions, rats continually alternated between self-stimulating one side of the brain or the other. Morphine induced a preference for the less sensitive side of the brain that was comparable in magnitude at all doses and independent of its biphasic effects on rates of responding. Naloxone induced a dose-related preference for the more sensitive side of the brain while not altering rates of responding. Naloxone (1.0 mg/kg) also completely antagonized the effects of all doses of morphine. The results are discussed in terms of lateralized actions mediating the discriminable effects of reinforcing drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428154
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Changes in morphine self-administration after tel-diencephalic lesions in rats (1978)
    Springer
    Psychopharmacology 57 (1978), S. 283-288 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Self-administration ; Frontal cortex ; Posterior cortex ; Hippocampus ; Medial forebrain bundle ; Medial thalamus ; Nucleus accumbens ; Tuberculum olfactorium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of moprhine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Doseresponse studies indicated that sensitivity to morphine's rewarding property was decreased by frontal cortical and hippocampal lesions. Lesions of the posterior cortex, the tuberculum olfactorium, and the nucleus accumbens had no effect on self-administration behavior. The results are discussed in relation to previous findings with caudate and brainstem lesions. A neuroanatomical substrate for morphine reinforcement is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426752
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Morphine dependence in rats with medial forebrain bundle lesions (1973)
    Springer
    Psychopharmacology 30 (1973), S. 343-348 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Withdrawal ; Addiction ; Dependence ; Medial Forebrain Bundle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats with posterior medial forebrain bundle (PMFB) lesions and control rats were administered morphine chronically for 4 or 5 days via implanted subcutaneous silicone reservoirs. Following cessation of morphine administration after five days, PMFB rats showed less withdrawal-induced weight loss than control rats. Other PMFB and control rats were subjected to forced drinking of morphine solution for 9 days. PMFB rats consumed the morphine solution much more readliy than control rats, whereas intake of a quinine solution was similar in two other PMFB and control groups. These results suggest that the addictive and dependence properties of morphine may have separate mechanisms and based on previously reported neurochemical effects of PMFB lesions, that biogenic amines may be differentially involved in such mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429193
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effects of morphine on sleep in the cat (1972)
    Springer
    Psychopharmacology 24 (1972), S. 435-448 
    Details
    ISSN: 1432-2072
    Keywords: Sleep ; Morphine ; Naloxone ; α-Methyltyrosine ; 5-Hydroxy-tryptophan.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of morphine sulfate, 300 μg/kg s.c., on the sleep of cats was studied by electroencephalographic techniques. In contrast to placebo experiments the animals were awake for approximately 6 h after administration of morphine; the return of regular sleep patterns occurred after about 11 h. A rebound increase in rapid eye movement (REM) sleep time and percentage was noted during the 11th through the 17th hour of the study. Sleep following manual sleep deprivation for 10 h showed a rebound increase in REM and non-rapid eye movement (NREM) sleep time. NREM sleep rebound after manual sleep deprivation exceeded that occurring after morphine. The alerting actions of morphine could be blocked by naloxone, 100 μg/kg s.c., for about 90 min. Naloxone alone increased REM sleep time and percentage. Single (84 mg/kg) or multiple (51 mg/kg for 4 injections) doses of dl-α-methyltyrosine i.p. did not block the alerting action or REM sleep rebound caused by morphine. 5-Hydrotryptophan (30 mg/kg) i.p. did not antagonize the alerting action of morphine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402538
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Changes in morphine self-administration after brainstem lesions in rats (1977)
    Springer
    Psychopharmacology 52 (1977), S. 151-156 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Self-administration ; Substantia nigra ; Midbrain raphe nuclei ; Locus coeruleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to bar press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were reduced by bilateral lesions of the substantia nigra and enhanced by lesions of the medial raphe nucleus. Dose-response studies indicated that sensitivity to morphine's rewarding property was increased by substantia nigra lesions and decreased by medial raphe lesions. Lesions of the dorsal raphe nucleus and of the locus coeruleus had no effect on self-administration behavior. An interaction between ascending dopaminergic and serotonergic pathways appears to be involved in the mechanism of morphine reinforcement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439102
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Surface fine structure of the eye of the housefly (Musca domestica): Ommatidia and lamina ganglionaris (1974)
    Springer
    Cell & tissue research 149 (1974), S. 21-41 
    Details
    ISSN: 1432-0878
    Keywords: Compound eye ; Musca domestica ; Ommatidia ; Optic cartridge ; Basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The compound eye of the housefly, from lens to first optic neuropile (lamina ganglionaris) was examined with a scanning electron microscope. Key findings are as follows: The pseudocone cavity is enclosed by six corneal pigment cells. The nuclei of the six cells are firmly anchored to the underside of the lens and portions remain after lens delamination from the pseudocone cavity. An eccentrically-positioned, short photoreceptor cell was observed near the region where the inferior central cell initiates its rhabdom. This eminence may represent that cell's soma. The basement membrane is revealed as a two-tiered, fibrous layer with ovoid fenestrations. Each opening is sealed with a diaphragm perforated by eight retinular axons and a trachea. Conjoined distal surfaces of the satellite glial cells form a membrane-like barrier immediately underlying the basement membrane. Monopolar somata from the lamina are covered with glial cells which possibly make more intimate contact with the somata through miniscule projections. Optic cartridges with monopolar interneurons were noted. Spherical to slightly biconcave processes of these interneurons contact retinular axons. Very fine (1000 Å) filaments interweave among and contact lateral processes. Further implications are discussed as they relate to observed structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209048
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The large pigment cell of the compound eye of the house fly Musca domestica (1976)
    Springer
    Cell & tissue research 170 (1976), S. 77-88 
    Details
    ISSN: 1432-0878
    Keywords: Compound eye ; House fly ; Large pigment cells ; Corneal pigment cells ; High voltage and conventional electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure and cellular associations of the large pigment cells (LPC's) of the compound eye of the house fly were studied with high voltage and conventional electron microscopy. Depending on the sector of the compound eye, the facets are either rectangular or hexagonal. The underside of each facet has indentations exactly aligned with those on top into which inserts an angulated sleeve of LPC's. Under the rectangular lens facet 6 or 8 small compact (in cross section) LPC's join four elongate LPC's. Clusters of compact cells alternate in this ring with elongate ones. Compact cells compress together and become quadrangular (in cross section) several microns below their insertion into the lens and form “building block” corners while elongate cells form “side rails” for the rectangular type of distal pseudocone enclosure. Beneath hexagonal facets all LPC's are rather elongate with out corner cells. In both facet types LPC's enclose the pseudocone for a longitudinal distance of 4 μm and then are displaced as bordering cells by a sleeve of two corneal pigment cells (CPC's), each of which encloses half of the proximal pseudocone. For the following 6 μm of longitudinal distance these concentric sleeves of CPC's and LPC's form a double layer around the pseudocone. At about 10 μm below lens base the two sleeves separate; LPC's become attenuated and extend cable-like to the basement membrane and CPC's enclose the proximal pseudocone, Semper cells and distal retinula. The junction between lens and LPC's has critical structural value in that (1) this is the sole anchorage to the lens by the lengthy remainder of the ommatidium, and (2) LPC's enclose the semiliquid pseudocone in the most distal portion of the pseudocone. In addition to vertical support, the LPC's send out numerous lateral processes that make structural contact among themselves, with the corneal pigment cells and the photoreceptor cells. The structural features of this array are discussed relative to possible physiological roles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220111
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure and blood-brain barrier in diapause and nondiapause larvae of the European corn borer Ostrinia nubilalis (Hübner) (1975)
    Springer
    Cell & tissue research 162 (1975), S. 499-510 
    Details
    ISSN: 1432-0878
    Keywords: Blood-brain barrier ; Moth ; Diapause ; ATPase ; Peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ultrastructural examination of diapause and nondiapause larval brains of the European corn borer disclosed anatomical differences that may be related to the insect's “blood-brain barrier.” The perineurial type I cells are quite closely appressed in the diapause brain, but thrown into extensive folds with large intercellular spaces in the nondiapause brain. The perineurial type II cells of diapause and nondiapause larvae are basically similar in general ultrastructure, and most likely form the basis for the “blood-brain barrier.” Horseradish peroxidase penetration studies indicated that the outer margin of the perineurial type II cells constitute the limits of infiltration into the brain. An enzymatic component of the “blood-brain barrier” is postulated in this insect. The localization of ATPase in the perineurial type II cells indicates that energy-requiring regulatory mechanisms may be localized here. Metabolic studies with isolated insect brains, coupled with recent evidence from mammalian systems, suggest that glial cells may be of importance in an enzymatic “blood-brain barrier.”
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209349
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Analog of vertebrate anionic sites in blood-brain interface of larval Drosophila (1994)
    Springer
    Cell & tissue research 277 (1994), S. 87-95 
    Details
    ISSN: 1432-0878
    Keywords: Blood-brain barrier ; Anionic sites ; Larvae ; Septate junctions ; CNS ; Glia ; Ultrastructure ; Drosophila melanogaster (Insecta)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The blood-brain barrier ensures brain function in vertebrates and in some invertebrates by maintaining ionic integrity of the extraneuronal bathing fluid. Recent studies have demonstrated that anionic sites on the luminal surface of vascular endothelial cells collaborate with tight junctions to effect this barrier in vertebrates. We characterize these two analogous barrier factors for the first time on Drosophila larva by an electron-dense tracer and cationic gold labeling. Ionic lanthanum entered into but not through the extracellular channels between perineurial cells. Tracer is ultimately excluded from neurons in the ventral ganglion mainly by an extensive series of (pleated sheet) septate junctions between perineurial cells. Continuous junctions, a variant of the septate junction, were not as efficient as the pleated sheet variety in blocking tracer. An anionic domain now is demonstrated in Drosophila central nervous system through the use of cationic colloidal gold in LR White embedment. Anionic domains are specifically stationed in the neural lamella and not noted in the other cell levels of the blood-brain interface. It is proposed that in the central nervous system of the Drosophila larva the array of septate junctions between perineurial cells is the physical barrier, while the anionic domains in neural lamella are a “charge-selective barrier” for cations. All of these results are discussed relative to analogous characteristics of the vertebrate blood-brain barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303084
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    The distal ommatidium of the compound eye of the housefly (Musca domestica): A scanning electron microscope study (1975)
    Springer
    Cell & tissue research 159 (1975), S. 379-385 
    Details
    ISSN: 1432-0878
    Keywords: Compound eye ; Musca domestica ; Ommatidium ; Distal retinula ; Scanning electron microscopy ; Corneal lens ; Corneal pigment cell ; Pseudocone ; Semper cell ; Basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distal aspect of the housefly ommatidium was surveyed by the scanning electron microscope. Attention was directed to the somal eminence of the superior central cell and the lens to large pigment cell junction. The underside of each lens facet exhibits six hexagonally arranged incisures. Into each of these indentations are fitted several large pigment cells. This hexagonal indentation appears to be a tenacious anchorage. Two corneal pigment cells laterally encircle the pseudocone and at their proximal extension they enclose the Semper cells and neck of the retinula. The somal eminence of the superior central cell is about 10 μm from the base of the corneal pigment cell enclosure. Micrographs were used to construct a diagram of the ommatidium above the basement membrane. Suggestions are made as to the functional correlates of the observed ommatidial structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221784
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...