Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 46 (1997), S. 964-968 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Hämodilution ; Allogene Transfusion ; Fremdblutsparende Maßnahmen ; Anämie ; Hyperoxische Beatmung ; Key words Hemodilution ; Allogeneic blood transfusion ; Blood-saving methods ; Anemia ; Hyperoxic ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract We report the case of a 22-year-old woman who underwent two-step scoliosis surgery without allogeneic transfusion, although the intraoperative blood loss (3500 ml) during the first procedure was higher than the calculated blood volume (3250 ml). Preoperatively the patient had donated four units of autologous blood. Intraoperatively blood-saving methods were combined. During the first operation acute normovolemic hemodilution (target hemoglobin 9.0 g/dl) was applied and during the second operation controlled hypotension (systolic blood pressure 80 mmHg). Intraoperative autotransfusion was used in both procedures. During the first operation severe normovolemic anemia (minimal hemoglobin 3.5 g/dl) was accepted while the patient was ventilated with FiO2 1.0. The hemoglobin concentration was 8.6 g/dl after the first procedure and had increased to 11.6 g/dl 4 weeks after the second procedure. No severe complications occurred during the postoperative phase. This case report shows that also in surgical procedures with extreme blood loss any allogeneic transfusion can be avoided by the combination of blood-saving methods, acceptance of low intraoperative transfusion trigger and ventilation with 100% oxygen.
    Notes: Zusammenfassung Der vorliegende Fallbericht beschreibt, wie bei einer 22jährigen Patientin während einer zweizeitigen Respondylodeseoperation jegliche allogene Transfusion vermieden werden konnte, obwohl der Gesamtblutverlust (3500 ml) beim Ersteingriff das berechnete Blutvolumen (3250 ml) überstieg. Präoperativ hatte die Patientin 4 Eigenblutkonserven gespendet. Intraoperativ wurden fremdblutsparende Techniken kombiniert: während des Ersteingriffs wurden eine präoperative normovolämische Hämodilution (Zielhämoglobinkonzentration 9,0 g/dl), während des Zweiteingriffs eine kontrollierte Hypotension (systolischer Blutdruck 80 mmHg) durchgeführt, bei beiden Eingriffen wurde außerdem intraoperativ ein Cell-Saver eingesetzt. Im Rahmen der akuten normovolämischen Hämodilution (ANH) wurde beim Ersteingriff eine ausgeprägte, normovolämische Anämie (minimale Hämoglobinkonzentration 3,5 g/dl) während Beatmung mit einer FiO2 von 1,0 akzeptiert. Nach dem Ersteingriff betrug die Hämoglobinkonzentration 8,6 g/dl und war 4 Wochen nach dem Zweiteingriff auf 11,6 g/dl angestiegen. Der postoperative Verlauf war nach beiden Eingriffen komplikationslos. Dieser Fall zeigt, daß durch die Akzeptanz und Kombination von fremdblutsparenden Techniken, niedriger intraoperativer Transfusionstrigger und Beatmung mit reinem Sauerstoff elektive Eingriffe mit extremem Blutverlust ohne allogene Transfusionen durchgeführt werden können.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1238
    Keywords: Key words Aerosols ; Epoprostenol ; Toxicity ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h. Design: In a prospective, randomized study 14 healthy lambs received either PGI2 (n=7) or 0.9% NaCl (n=7) as an aerosol for 8 h. Setting: Institute for Surgical Research of the Ludwig-Maximilians- University of Munich. Interventions: All animals were studied under general anesthesia in a prone position. They were first intubated endotracheally and later tracheotomized. PGI2 solution (median dose 28 ng/kg per min) or 0.9% NaCl was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Bronchoalveolar lavage was performed before and after the inhalation period to collect epithelial lining fluid of alveoli. Measurements and results: Hemodynamic and respiratory parameters, systemic resorption (plasma levels of 6-keto-prostaglandin-F1α), in vitro bleeding time, collagen-induced platelet aggregation and global biochemical and cellular composition of the epithelial lining fluid were examined in order to assess the side effects and signs of acute pulmonary toxicity induced by inhaled PGI2. No statistically significant differences were found between the PGI2 and the control groups for any of the parameters examined. Conclusion: Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1238
    Keywords: Key words Aerosols ; Epoprostenol ; Toxicity lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study potential toxic effects of long-term (8 h) inhaled prostacyclin (PGI2) on respiratory tract tissues. Design: In a prospective, randomized order, either PGI2 (n=7) or normal saline (n=7) was aerosolized during a time period of 8 h in healthy lambs. Setting: Institute for Surgical Research of the Ludwig-Maximilians University of Munich. Animals: 14 healthy, anesthetized, ventilated lambs. Interventions: All animals were endotracheally intubated followed by tracheotomy. PGI2 solution or normal saline was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Measurements and results: Histomorphological changes after 8-h inhalation of PGI2 solution were compared to those after 8-h inhalation of normal saline. Tracheal and bronchoalveolar tissues were examined by light and electron microscopy in order to assess tissue damage induced by inhaled PGI2. Pathological changes were ranked by a blinded observer following a graduation system ranging from ”absence of pathological changes“ to ”maximal pathological changes“. Abnormalities were restricted to the trachea (focal flattening of the epithelium, loss of cilia, slight inflammatory cell infiltration) and alveolar tissue (focal alveolar septal thickening with slight inflammatory cell infiltration), but no statistically significant differences between the PGI2 and control groups were encountered. Conclusion: Our findings indicate the absence of PGI2 aerosol-related respiratory tissue damage after 8-h inhalation of PGI2.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-1238
    Keywords: Aerosols ; Epoprostenol ; Toxicity lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To study potential toxic effects of long-term (8 h) inhaled prostacyclin (PGI2) on respiratory tract tissues. Design In a prospective, randomized order, either PGI2 (n=7) or normal saline (n=7) was aerosolized during a time period of 8 h in healthy lambs. Setting Institute for Surgical Research of the Ludwig-Maximilians University of Munich. Animals 14 healthy, anesthetized, ventilated lambs. Interventions All animals were endotracheally intubated followed by tracheotomy. PGI2 solution or normal saline was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Measurements and results Histomorphological changes after 8-h inhalation of PGI2 solution were compared to those after 8-h inhalation of normal saline. Tracheal and bronchoalveolar tissues were examined by light and electron microscopy in order to assess tissue damage induced by inhaled PGI2. Pathological changes were ranked by a blinded observer following a graduation system ranging from “absence of pathological changes” to “maximal pathological changes”. Abnormalities were restricted to the trachea (focal flattening of the epithelium, loss of cilia, slight inflammatory cell infiltration) and alveolar tissue (focal alveolar septal thickening with slight inflammatory cell infiltration), but no statistically significant differences between the PGI2 and control groups were encountered. Conclusion Our findings indicate the absence of PGI2 aerosol-related respiratory tissue damage after 8-h inhalation of PGI2.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-1238
    Keywords: Aerosols ; Epoprostenol ; Toxicity ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h. Design In a prospective, randomized study 14 healthy lambs received either PGI2 (n=7) or 0.9% NaCl (n=7) as an aerosol for 8 h. Setting Institute for Surgical Research of the Ludwig-Maximilians-University of Munich. Interventions All animals were studied under general anesthesia in a prone position. They were first intubated endotracheally and later tracheotomized. PGI2 solution (median dose 28 ng/kg per min) or 0.9% NaCl was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Bronchoalveolar lavage was performed before and after the inhalation period to collect epithelial lining fluid of alveoli. Measurements and results Hemodynamic and respiratory parameters, systemic resorption (plasma levels of 6-keto-prostaglandin-F1α), in vitro bleeding time, collagen-induced platelet aggregation and global biochemical and cellular composition of the epithelial lining fluid were examined in order to assess the sie effects and signs of acute pulmonary toxicity induced by inhaled PGI2. No statistically significant differences were found between the PGI2 and the control groups for any of the parameters examined. Conclusion Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...