Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Bone mineral density  (3)
  • immunoassays  (3)
  • Bone densitometry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Bone loss during gonadotropin releasing hormone agonist treatment and use of nasal calcitonin (1995)
    Springer
    Osteoporosis international 5 (1995), S. 185-190 
    Details
    ISSN: 1433-2965
    Keywords: Bone densitometry ; Calcitonin ; Gonadotropin releasing hormone agonists ; Osteopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gonadotropin releasing hormone (GnRH) agonists have shown to be effective in the treatment of several sex-hormone-dependent conditions. However, their use could be limited by the bone loss they induce. To evaluate the use of nasal salmon calcitonin (sCT) in preventing this bone loss, 40 patients with endometriosis were treated for 6 months with triptoreline (3.75 mg monthly) and calcium (1 g daily), and randomized in three groups — placebo, sCT 100 IU daily and sCT 200 IU daily — in a prospective double-masked study. Dual-energy X-ray absorptiometry and biochemical parameters were used to evaluate the benefit of the treatment. At baseline, there were no statistically significant differences between the groups. After 6 months, estradiol and biochemical markers of bone metabolism were at postmenopausal levels, with no difference between the groups. There was no difference in bone loss in the three groups, at all sites. Mean lumbar bone loss was 4.01±2.59% (mean±SD) in this population. In this study dosages of 100 IU and 200 IU daily of nasal sCT were insufficient to prevent bone loss during GnRH agonist treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106098
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of cyclical etidronate therapy on bone loss in early postmenopausal women who are not undergoing hormonal replacement therapy (1997)
    Springer
    Osteoporosis international 7 (1997), S. 213-218 
    Details
    ISSN: 1433-2965
    Keywords: Bone mineral density ; Dual-energy X-ray absorptiometry ; Etidronate ; Postmenopausal osteoporosis ; Postmenopausal bone loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was carried out to investigate the effectiveness and tolerability of cyclical etidronate therapy in the prevention of bone loss occurring in early postmenopausal women who are not undergoing hormone replacement therapy (HRT). A total of 109 Caucasian women aged 45–60 years were treated with etidronate 400 mg/day or placebo for 14 days followed by calcium supplementation 500 mg/day for 77 days. Ninety-one women completed the 2 years of the study. After 2 years, the estimated difference between the two groups as regards lumbar spine bone mineral density (BMD) was 2.53% (SEM 1.07%;p=0.01); BMD of the hip and wrist were not significantly different between treatment groups. A clear reduction in bone turnover was obtained as evidenced by a significant decrease in serum alkaline phosphatase level and in urinary N-telopeptide/creatinine ratio in the etidronate group; the difference between the two groups was −12%±3.2% for serum alkaline phosphatase level (p=0.019) and −22.9%+13.7% for the urinary N-telopeptide/creatinine ratio (p=0.047). There was no statistically significant difference between the two groups in terms of the serum osteocalcin levels and urinary hydroxyproline/creatinine and calcium/creatinine ratios. Etidronate was generally well tolerated and its adverse event profile was similar to that of placebo. The results of this study indicate that cyclic etidronate therapy can prevent trabecular bone loss, with no deleterious effect on cortical bone, in the first 5 years of menopause and that it has a very high safety margin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622291
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Assessment of the relationship between broadband ultrasound attenuation and bone mineral density at the calcaneus using BUA imaging and DXA (1997)
    Springer
    Osteoporosis international 7 (1997), S. 316-322 
    Details
    ISSN: 1433-2965
    Keywords: Bone mineral density ; Broadband ultrasound attenuation ; Calcaneus ; Ultrasound imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purposes of this study was to determine the relationship between broadband ultrasound attenuation (BUA) and bone mineral density (BMD) measured at different regions of the calcaneus with identical site-matched regions of interest (ROIs). Dual-energy X-ray absorptiometry (DXA) measurements of the calcaneus and BUA imaging were performed in 30 women (15 premenopausal and 15 postmenopausal). Four square ROIs were located in the great tuberosity and one square ROI in the foramen calcaneus. A ROI adapted to the shape and size of the whole calcaneus was also considered. All ROIs were analyzed three times with both techniques to minimize intra-observer variability. The correlation coefficient between attenuation and frequency was used as an index of BUA measurement error. Before accepting a measurement of BUA in inhomogeneous material, it could be useful to map the spatial variations of the measurement error. In all ROIs we found the BUA and BMD were strongly related (r=0.78−0.91,p〈0.001). The correlation between BUA and BMD was slightly higher in the inferior part of the posterior tuberosity than in the superior part and in the foramen calcaneus. The very high correlation between attenuation and frequency found in all ROIs (r=0.99) suggests that measurement errors of propagation were probably not significant. Ultrasound imaging yields the opportunity for studying the spatial acoustic properties in the calcaneus and their relation to bone mass or structural parameters provided by independent imaging techniques. BUA measured with current transmission techniques reflects mainly bone mass, and microarchitecture to a smaller extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623771
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Bone loss in patients with inflammatory bowel disease: A prospective study (1995)
    Springer
    Osteoporosis international 5 (1995), S. 156-160 
    Details
    ISSN: 1433-2965
    Keywords: Bone mineral density ; Ileoanal anastomosis ; Inflammatory bowel disease ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the rate of bone loss in patients with inflammatory bowel disease, we prospectively studied 35 patients (17 women) aged 36±13 (range 17–60) years, 14 of whom had Crohn's disease and 21 with ulcerative colitis (including 12 with ileoanal anastomosis). Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck. The follow-up was 19±8 months. During this period, 14 patients received oral steroids. Lumbar bone density changes expressed as a percentage per year were −3.1±4.9%, −6.4±7.5% and +2.0±4.0% in Crohn's disease and ulcerative colitis without and with ileoanal anastomosis respectively (p=0.007). The same pattern was observed at the femoral neck. Mean annual lumbar bone density changes were −6.2±7.0% and +0.9±3.9% in patients with and without steroids during follow-up (p=0.002). We conclude that patients with inflammatory bowel disease are at risk of lumbar and femoral bone loss. However, bone loss is not observed in patients with ileoanal anastomosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106094
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Antibody-Antigen Reactions in Porous Sol-Gel Matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 663-666 
    Details
    ISSN: 1573-4846
    Keywords: sol-gel ; immunoassays ; antigen ; antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Porous silica gels, synthesized via the acid hydrolysis and basic condensation of TMOS, have been used for the encapsulation of antigens. The pores of the matrix are large enough to allow the diffusion of antibodies through the gel. Antigen-antibody specific fixation occurs within the sol-gel matrix. It can be detected via the so-called enzyme linked immunosorbent assays (ELISA). Antigen-antibody associations occurring in the gel are optically detected via the reaction of a peroxidase conjugate with ortho-phenylenediamine leading to the formation of a yellow coloration. Immunoassays have been performed using the hydatid cyst fluid as the source of antigens and sera from human patients as the source of antibodies. Specific fixation appears to be as good in the sol-gel matrix as in antigen solutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018380512509
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Antibody-antigen reactions in porous sol-gel matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 663-666 
    Details
    ISSN: 1573-4846
    Keywords: sol-gel ; immunoassays ; antigen ; antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Porous silica gels, synthesized via the acid hydrolysis and basic condensation of TMOS, have been used for the encapsulation of antigens. The pores of the matrix are large enough to allow the diffusion of antibodies through the gel. Antigen-antibody specific fixation occurs within the sol-gel matrix. It can be detected via the so-called enzyme linked immunosorbent assays (ELISA). Antigen-antibody associations occurring in the gel are optically detected via the reaction of a peroxidase conjugate with ortho-phenylenediamine leading to the formation of a yellow coloration. Immunoassays have been performed using the hydatid cyst fluid as the source of antigens and sera from human patients as the source of antibodies. Specific fixation appears to be as good in the sol-gel matrix as in antigen solutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436919
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Immunoassays in sol-gel matrices (1996)
    Springer
    Journal of sol gel science and technology 7 (1996), S. 45-51 
    Details
    ISSN: 1573-4846
    Keywords: sol-gel ; immunoassays ; porosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Parasites have been encapsulated within sol-gel silica matrices. Thermoporometry measurements show that the pore size depends strongly on experimental conditions. Pores as large as 100 Å in diameter can be obtained, allowing the diffusion of large biomolecules such as immunoglobulins. TEM observations, performed on procaryote (bacteria) and eucaryote (protozoa) specimen show that the cellular organization and the integrity of the plasma membrane of entrapped parasites are preserved. Moreover they retain their antigenic activity and can react specifically with the corresponding antibodies. Sol-gel matrices have then been used for the realization of enzyme-linked immunosorbent assays (ELISA) directly with the sera of infected patients. Two examples are described, one with parasitic protozoa, Leishmania, and the other one with the cystic hydatid stage of tapeworm parasites, Echinococcus granulosus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401882
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...