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  • 1
    Digitale Medien
    Digitale Medien
    Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal male (1978)
    Springer
    Calcified tissue international 26 (1978), S. 103-106 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Osteoporosis ; Hypogonadism ; Bone formation ; Testosterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Osteoporosis has been reported to complicate androgen deficiency in males. Accordingly, we have evaluated an osteoporotic hypogonadal male with bone histomorphometry before and after 6 months of testosterone replacement. Androgen therapy resulted in increases in relative osteoid volum, total osteoid surface, linear extent of bone formation, and bone mineralization. The dramatic histological response to hormonal replacement confirms the importance of androgens in bone modeling and remodeling.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013243
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ultrastructure of the rat epiphyseal growth plate following chronic ethanol ingestion (1981)
    Springer
    Calcified tissue international 33 (1981), S. 381-384 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Alcohol ; Electron microscopy ; Growth plate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary We have previously demonstrated that ethanol has a direct toxic effect on the rat skeleton characterized by decreased trabecular bone volume. In the present study, we examined the ultrastructure of the distal radial epiphyseal growth plates in these same animals. Eight weeks of ethanol administration to 12 male rats results in serum alcohol levels of 140 mg/dl but did not alter the width or light microscopic appearance of the radial growth plate. Quantitative electron microscopy failed to demonstrate morphologic evidence of toxicity in the skeletal cells. We conclude that although ethanol appears to have a direct effect on rat bone characterized by enhanced resorption, toxicity is not attended by ultrastructural changes in the skeletal cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02409460
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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