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  • Organic Chemistry  (10)
  • Fetus  (3)
  • Brain barrier  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Experimental allergic encephalomyelitis (1981)
    Springer
    Acta neuropathologica 54 (1981), S. 149-152 
    Details
    ISSN: 1432-0533
    Keywords: Experimental allergic encephalomyelitis ; Blood ; Brain barrier ; Fibrinogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Classical acute allergic encephalomyelitis (EAE) was provoked in Lewis rats with bovine spinal cord (BWM) in complete Freund's adjuvant (CFA). An efficient immunohistologic technique (peroxidase-antiperoxidase (PAP)) was used to trace exsudates of fibrinogen and immunoglobulin as well as their coexistence with cellular infiltrates and clinical signs. Exsudation was restricted to the vessels exhibiting cellular infiltrates. The findings do not lend support to the assumption that exsudation of circulating factors is the initial local event in EAE. It also remains open, whether the exsudation of fibrinogen and gamma globulin are responsible for the clinical symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689408
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolic and toxic behaviours of phthalimide derivatives in albino rat (1978)
    Springer
    Archives of toxicology 40 (1978), S. 255-261 
    Details
    ISSN: 1432-0738
    Keywords: Chloromethyl phthalimide ; Oxymethyl phthalimide ; Phthalimide ; Fetus ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Chlormethylphthalimid, Oxymethylphthalimid und Phthalimid werden verhältnismäßig schnell von der Albinoratte resorbiert. Nach oraler Verabreichung von Chlormethyl- und Oxymethylphthalimid an die Muttertiere ist in den Feten nur das Stoffwechselprodukt Phthalimid nachweisbar. Diese Befunde weisen im Zusammenhang mit Stoffwechseluntersuchungen an isolierten Feten auf einen intensiven Stoffwechsel in fetalen Geweben hin. Unterschiede zwischen dünnschichtchromatographischen und 15N-Untersuchungen lassen vermuten, daß Phthalimid durch Öffnung des Imidringes weiter zur Phthalamidsäure metabolisiert wird.
    Notes: Abstract Chloromethyl phthalimide, oxymethyl phthalimide, and phthalimide are absorbed by the albino rat at a comparatively high rate. Only phthalimide, the metabolic product, will be recordable from fetuses, following oral administration of chloromethyl phthalimide and oxymethyl phthalimide to pregnant rats. Those findings, in conjunction with metabolic studies applied to fetuses isolated by caesarian section, appear to suggest the occurrence of an intensive metabolism in fetal tissue. Certain differences established between results of thin-layer chromatography, on the one hand, and 15N studies, on the other, are likely to support the assumption that phthalimide is further metabolised by splitting the imide ring yielding phthalamic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310330
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  • 3
    Electronic Resource
    Electronic Resource
    Metabolic and toxic behavior of phthalimide derivates (1976)
    Springer
    Archives of toxicology 36 (1976), S. 127-137 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate insecticide ; Imidan ; Fetus ; Metabolism ; Phosphororganisches Insektizid ; Imidan ; Fetus ; Stoffwechsel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der eine Phthalimidgruppe enthaltende insektizide Thiophosphorsäureester Imidan wurde wegen der bestehenden strukturellen Beziehungen zum Thalidomid auf sein diaplazentares Auftreten und Verhalten in Ratten untersucht. Sein Übergang in embryonale Gewebe konnte bestätigt werden. Nach intraamniotischer Injektion in die erste linke Amnionhöhle ist eine Verteilung des Imidans bzw. 32-P-aktiver Verbindungen über beide Uterushörner nachzuweisen, wobei Abhängigkeiten der Konzentration zur Einwirkungszeit und Entfernung vom Injektionsort bestehen. Die Halbwertzeit des Imidans in isolierten Rattenfeten bzw. in Neugeborenen liegt zwischen 50 und 70 min. Imidoxon, die oxydierte Form des Imidans, besitzt eine kürzere Halbwertzeit, wodurch sein Vorkommen in nur geringen Mengen nach Imidanverabreichung erklärt wird.
    Notes: Abstract The organophosphate insecticide imidan includes a phthalimide group. Because of the structural relationship to the teratogenic compound thalidomide we have investigated its placental transfer and metabolic fate in rats. Its passage to embryonic tissues could be confirmed. After intraamniotic injection to the first amniotic cavity of the left uteri we could establish a distribution of imidan and 32P compounds throughout the uteri, the concentration depending upon the incubation time and the distances from the place of injection. The half-life of imidan, detected in the exteriorized fetuses or in newborns, was 50–70 min. Imidoxon, i.e., the oxidized form of imidan, has a diminished half-life. This fact explicates the presence of imidoxon only in small concentrations after application of imidan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351972
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  • 4
    Electronic Resource
    Electronic Resource
    Vorkommen von phosphororganischen Insecticiden im Fetus (1970)
    Springer
    Archives of toxicology 26 (1970), S. 17-22 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate Insecticides ; Fetus ; Phosphororganische Insecticide ; Fetus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Applikation von Methylparathion, Bromophos und Imidan an trächtige Albinoratten sind diese Wirkstoffe in der Placenta sowie in Leber, Gehirn und Muskelgeweben der Feten nachweisbar. Das PO-Isologe konnte beim Methylparathion in allen untersuchten embryonalen Geweben festgestellt werden. Bei den mindertoxischen Insecticiden Bromophos und Imidan war lediglich das PO-Isologe des Bromophos, das Bromoxon, in Spuren im Muskelgewebe der Feten nachweisbar.
    Notes: Summary Following application of Methylparathion, Bromophos and Imidan in pregnant albino rats, these compounds are detectable in the placenta as well as in the liver, brain and muscle tissue of the fetus. The organophosphate isologe of Methylparathion could be found in all embryonic tissue studied. By the less toxic insecticides Bromophos and Imidan, only traces of the Bromophos isologe Bromoxon could be detected in the muscle tissue of the fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577963
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  • 5
    Electronic Resource
    Electronic Resource
    Komplexone V. Die Äthylendiamin-tetraessigsäure (1947)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 30 (1947), S. 1798-1804 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19470300649
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  • 6
    Electronic Resource
    Electronic Resource
    Komplexone XVII. Die Diaminocyclohexan-N,N′-Tetraessigsäuren als Komplexbildner für Erdalkalien (1949)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 32 (1949), S. 1682-1689 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Von den N,N′-Tetraessigsäuren der drei Diaminocyclohexane wurden die Aciditätskonstanten sowie die Bildungskonstanten der Ca- und Mg-Komplexe ermittelt.1. Die Aciditätskonstanten zeigen keine grossen Unterschiede gegenüber denjenigen der entsprechenden Tetraessigsäuren der offenkettigen Polymethylendiamine. Auffallend sind einzig die grossen Werte für PK2 und PK4 der 1,2-Verbindung, die darauf hinweisen, dass die vier Carboxylgruppen sich hier räumlich besonders nahe sind und sich eine Wasserstoffbrücke zwischen den beiden Stickstoffatomen ausbilden kann.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19490320539
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  • 7
    Electronic Resource
    Electronic Resource
    Konstitution und Reaktionsfähigkeit von Trichlor-pyrimidylamino-Verbindungen (1962)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 45 (1962), S. 1683-1698 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2,4,5,6-Tetrachlorpyrimidin wurde mit Ammoniak, aliphatischen und aromatischen Aminen umgesetzt und es konnte gezeigt werden, dass dabei fast ausschliesslich das Chlor in 4-Stellung des Pyrimidinrings substituiert wird.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19620450535
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  • 8
    Electronic Resource
    Electronic Resource
    Über eine neue Synthese von UracilderivatenHerrn Prof. Dr. E. Ziegler, Universität Graz, zum 60. Geburtstag gewidmet (1972)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 55 (1972), S. 1039-1043 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: When N,N-dialkylamide dimethylsulfate adducts are reacted with cyanoacetyl urea or carbethoxy acetyl urea, the corresponding dialkylamino alkylidene derivatives are formed which cyclize to substituted uracils in the presence of a strong base. When the adducts of cyclic amides are used, the lactam ring is opened simultaneously on cyclisation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19720550329
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  • 9
    Electronic Resource
    Electronic Resource
    Komplexone XXII. Die Kinetik der Komplexbildung: Der Austausch des Y-4 zwischen Cd+2 und Cu+2 (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 485-497 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mechanism of the reaction between cupric ion and the cadmium complex of ethylenediamine tetraacetic acid (= H4Y) has been studied. The reaction proceeds simultaneously via four different reaction paths brought about through the collision of the cation Cu+2 with the anions CdY-2, CdHY-, HY-3, H2Y-2 which are in permanent equilibrium with each other. The rate constants of these four bimolecular reactions have been evaluated and discussed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350214
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  • 10
    Electronic Resource
    Electronic Resource
    Metallkomplexe mit Polyaminen VIII: Äthylendiamin und Silber (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 2337-2343 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In solutions containing ethylenediamine „en“, and Silver(I), the complexes: AgHen+2, Ag(en)+, Ag2(en)+2 Ag(en)+2 and, surprisingly, Ag2(en)2+2 are formed. The stability constants of these complexes have been evaluated. The existence of the dimeric form of Ag(en)+, probably a 10-membered ring compound, has been prooved also with cryoscopic measurements, using the cristalline sulfate: [Ag2en2]SO4.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350720
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