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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 52 (1983), S. 423-428 
    ISSN: 1432-1106
    Keywords: Human posture ; Postural “reflexes” ; Change of latency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The functional role of spinal and supraspinal EMG-responses for the maintenance of upright human posture was investigated in ten healthy subjects standing on a force measuring platform, which could be rotated in pitch around an axis aligned with the subject's ankle joint. Voluntary changes of body posture prior to the platform movement by leaning forward or backward led to a change in the amplitude and temporal organization of EMG-responses as compared to platform movements starting from a neutral position. Tilting the platform toe-up while leaning backward led to an increase of the latency of the short- and medium-latency responses in the triceps surae muscle and to a decrease of the latency of the stabilizing response in the anterior tibial muscle. Functionally, a cocontraction of both antagonistic muscles could be observed which partly compensated for the destabilizing action of the “reflex” response in the stretched triceps surae muscle. In analogy, leaning forward and tilting the platform toedown led to a cocontraction of the two antagonistic muscles. The observed changes of latencies of short-, medium-, and long-latency response show the functional variability of segmental and suprasegmental “reflex” mechanisms. EMG-activities, which are functionally destabilizing posture, can be suppressed or compensated by reflexive cocontractions of antagonists.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 45 (1982), S. 126-132 
    ISSN: 1432-1106
    Keywords: Human posture ; Induced sway ; Visual stabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Displacements of the center of foot pressure, the hip and the head were recorded in six subjects standing on a platform, sinusoidally tilting in pitch(anterior-posterior).Stimulusfrequenciesranged between 0.01 and 1 Hz. Stimulus amplitudes were 2, 4 and 6 °. With eyes open the displacements were minimal at 0.3 Hz. With eyes closed, however, induced sway was maximal at this frequency. The apparent lack of visual stabilization at the lowest frequency (0.01 Hz) might be attributed to a subthreshold velocity of the retinal image motion induced by the swaying body. A similar absence of visual stabilization at 1 Hz is assumed to indicate the limit of the working range of visual stabilization of posture. Independent of stimulus amplitude a phase lead of about 90 ° was found at 0.01 Hz. This decreased with increasing frequency up to a phase lag of 100 ° at the highest frequency (1 Hz). Head stabilization was generally more effective than hip stabilization. EMG recordings from the leg muscles suggest that with eyes closed the center of force is mainly stabilized by leg muscle activity, while with eyes open this stabilization is best, when vision allows for stabilization of body posture by intersegmental movements between head, trunk and legs.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD.
    Type of Medium: Electronic Resource
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