Bibliothek

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Engineering General  (3)
  • C++  (1)
  • Computed tomography  (1)
  • Key words: SLE — Cytokines — B-cells — Autoantibodies  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Inflammation research 48 (1999), S. 255-261 
    ISSN: 1420-908X
    Schlagwort(e): Key words: SLE — Cytokines — B-cells — Autoantibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Systemic lupus erythematosus (SLE) is an autoimmune disease most prevalent in women between the ages of twenty and sixty. Successful treatment remains challenging due to a lack of understanding of the underlying mechanisms and multiple symptoms ranging from skin rashes to glomerulonephritis. The pathogenesis of SLE has been linked to a B-cell hyperproliferation unique to afflicted patients. These B-cells generate large quantities of IgG autoantibodies, ultimately capable of leading to lupus nephritis and renal failure. The significance of cytokines in SLE and in murine lupus, a related disease in mice, has been debated, particularly with respect to B-cell activity. Potential roles of auto-regulatory and inflammatory cytokines have been investigated. In particular, IL-6 and IL-10 have been shown to be key factors in regulating autoantibody-secreting B-cell activity in lupus. Here, we will provide a critical overview of our current knowledge of the regulatory roles of these two cytokines in SLE.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 33 (1991), S. 438-440 
    ISSN: 1432-1920
    Schlagwort(e): Leukodystrophy ; Alexander's disease ; Computed tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case of biopsy proven Alexander's disease is described with extensive low density lesions in both frontal lobes, which in our experience, and on survey of the literature have not been described previously.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 35 (1992), S. 787-806 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The flow associated with the pouring of molten metal into moulds has been modelled based upon certain simplfying assumptions. A finite element based Navier-Stokes equation solver has been used to analyse the flow. The velocities obtained from the Navier-Stokes equation solver are used to advect a pseudo-concentration function for modelling the free fluid front. A simple problem with a known analytical solution is solved first to test the model. Subsequently, several more examples of varied geometrical configuration are modelled to demonstrate the applicability of the proposed model. The Taylor-Galerkin method has been used to model the heat transfer during filling due to its advection dominated nature.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 32 (1991), S. 767-781 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: An error estimation technique for adaptive finite element analysis of heat conduction problems is described. The performance of this technique is demonstrated using a two-dimensional steady-state linear benchmark problem with a known analytical solution. A transient non-linear heat conduction problem involving solidification is then solved as a typical practical application. Some preliminary investigations for error indicators in flow problems are presented.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2891-2909 
    ISSN: 0029-5981
    Schlagwort(e): C++ ; object-oriented ; solidification ; parallel ; Engineering ; Numerical Methods and Modeling
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper describes an implementation in C++ and in parallel of an explicit finite element formulation for the solution of transient heat conduction problems with phase change. The scheme requires a very small timestep because of its conditional stability, but, as no matrix inversion is required, the cost per timestep is an order of magnitude lower than for a conventional scheme.The principles of using object-oriented techniques for general finite element programming are briefly explained, while the advantages for parallel processing are described in detail, including the classes used to perform message passing.An example is given showing the performance of the scheme on two completely different parallel machines: a shared memory Silicon Graphics Power Challenge, and a distributed memory Cray T3D. The results indicate that the program scales efficiently for large meshes. © 1997 John Wiley & Sons, Ltd.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 20 (1995), S. 493-506 
    ISSN: 0271-2091
    Schlagwort(e): finite element method ; mould filling ; explicit Taylor-Galerkin ; pseudo-concentration ; interface elements ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: A model for simulating the process of mould filling in castings is presented. Many defects in a casting have their origins at the filling stage. Numerical simulation of this process can be of immense practical benefit to the foundry industry, however a rigorous analysis of this process must model a wide range of complex physical phenomena. In order to contain the costs and complexity that would be necessary for such a model, certain simplifying assumptions have been made. These assumptions limit the scope of this model to only predicting realistic thermal fields during the filling process.A laminar regime has been assumed for the flow field, which is obtained by solving the incompressible Navier-Stokes equations using a velocity-pressure segregated semi-implicit finite element method. The free metal surface is predicted by advecting a pseudo-concentration function via the computed flow field. This involves an explicit finite element solution of a pure advection equation. The thermal field is calculated by solving the convective-diffusive energy equation by an explicit finite element method using the computed flow field and the location of the free surface. All the advection terms are discretized using a Taylor-Galerkin method. The interface between the metal and mould is modelled using special interface elements.The model is demonstrated by solving practical example problems. The results show that a sharp thermal front is maintained during the course of filling without excessive diffusion. The heat diffusion in the mould can be controlled by varying the metal mould heat transfer coefficient.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...