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  • 1
    Electronic Resource
    Electronic Resource
    Calcium-activated neutral protease activities in brain trauma (1991)
    Springer
    Neurochemical research 16 (1991), S. 483-487 
    Details
    ISSN: 1573-6903
    Keywords: Calpain ; CANP ; brain ; cryogenic insult
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper investigates the level of cytosolic and synaptosomal forms of calcium activated neutral protease activities in the normal brain and their changes following a freezing lesion in the rabbit. From 1 to 24 hours post lesion we observe a progressive disappearing of the enzyme activities from the cytosolic compartment and concurrently their increase in the membranal fraction. These changes are likely to be due to a rise in intracellular calcium concentration, a well documented consequence of many cellular insults. The specific role of the activation of calpain activities in the pathophysiology of trauma is discussed, an enhancement of excitotoxic mechanisms is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00965570
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Na+−K+-ATPase activity of glial, neuronal, and synaptosomal enriched fractions from normal and freezing-injured rabbit cerebral cortex (1987)
    Springer
    Neurochemical research 12 (1987), S. 607-612 
    Details
    ISSN: 1573-6903
    Keywords: Na+−K+-ATPase ; freezing lesion ; brain edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper investigates the kinetic parameters of Na+−K+-ATPase in glial, neuronal, and synaptosomal enriched fractions isolated from rabbit cerebral cortex. Under normal conditions, kinetic parameters-Vmax and K 0.5 K+ -of Na+−K+-ATPase are the same in the three fractions, suggesting that this enzyme behaves as the same molecular entity. Following a cryogenic lesion, the alterations of these parameters appear to be different in the different fractions. These data suggest that the same enzyme exhibits various responses when exposed to the same pathological event. The dissimilar lipid composition of the Na+−K+-ATPase environment, and/or different adaptative responses to abnormal ion concentrations in glial, neuronal, and synaptosomal fractions could account for these different responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00971008
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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