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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Modifications of some membranal enzymatic activities in rabbit brain edema induced by cold injury were studied. The edema was characterized by the tissue H2O content and the K+/Na+ ratio. Comparison of the respiratory rate of isolated mitochondria in the state 3 and 4 and the ADP/O ratio suggested an alteration in the ATP synthesis mechanism. The oligomycin sensitive ATPase activity was severely reduced in mitochondria isolated from edematous cells.The alteration of the ouabain sensitive Na+-K+-ATPase was first qualitative in the sense where the response of the ATPase to the K+/Na+ ratio was modified. A loss of the total activity was then observed. Intravenous injection of CDP choline induced a regression of the edema, a restoration of the sensitivity of the mitochondrial ATPase towards oligomycin and a restoration of the sensitivity of the Na+-K+-ATPase to the K+/Na+ ratio. These results suggest that the reversible damages of the cells induced by cold injury were due to a disorder at the protein-lipid interaction level.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: This study investigates the functioning of synaptosomal ouabain-sensitive Na+-K+-ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is not changed. On the basis of these data, it is likely that Na+-K+-ATPase impairment accounts for the intracellular uptake of water in this model of edema.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 932 (1988), S. 116-123 
    ISSN: 0005-2728
    Keywords: (Rabbit) ; Brain edema ; Oxidative phosphorylation ; Succinate dehydrogenase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 130 (1994), S. 8-13 
    ISSN: 0942-0940
    Keywords: Images ; icons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Modern images have became essential to our daily work because they provide high quality representations which, with admittedly some difficulties and pitfalls, allow detection and diagnosis of lesions and moreover inspire and guide every step of surgery. This place and value of the image as the main source of technical information required for the patient's management is straightforward and raises no major epistemological problem. However our use of images easily escapes critical thinking. Images may impose their own power and rationality. Medical images are powerful for the patient and for the doctor because they contain an unlimited source of explanation for the disease, they make disease and functional complaints, comprehensible. They are important for the surgeons because they offer an unique and irreplaceable guide to the lesions, they make it visible, they give shape and in fact reality to what in the patient, belongs to surgery. This power of medical images is irrefutable because, rather than mere representations, they are analogical reflexions of the real body with its real lesions, there is an ontological continuity between image and reality. For these and some other reasons we are tempted to give to images a consideration which should be due only to the patient himself. This temptation is idolatrous in nature. Under a number of different aspects this tempation pervades the entire field of medicine and might ultimately narrow our vision of patients, our vision of man.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Keywords: Brain injury ; intensive care ; secondary insults ; clinical trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Guidelines for the management of severe head injury in adults as evolved by the European Brain Injury Consortium are presented and discussed. The importance of preventing and treating secondary insults is emphasized and the principles on which treatment is based are reviewed. Guidelines presented are of a pragmatic nature, based on consensus and expert opinion, covering the treatment from accident site to intensive care unit. Specific aspects pertaining to the conduct of clinical trials in head injury are highlighted. The adopted approach is further discussed in relation to other approaches to the development of guidelines, such as evidence based analysis.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 55 (1981), S. 169-179 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0942-0940
    Keywords: Keywords: Head injury; European survey; management; outcome.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  To provide a picture of contemporary practice, a survey was carried out of severely and moderately head injured patients admitted to 67 `neuro' centres in 12 European countries. 1,005 adult head injuries were recruited over a three month period. Sixty items of information on demography, clinical features, investigations, management and early complications were captured on a simple, two-page questionnaire and, information on outcome at six months on a third page.  The median age of the subjects was 38 years, 74% were male and 51% injured in road traffic accidents; 57% of patients were transferred to the `neuro' centre from another hospital. Assessment of clinical responsiveness was limited by the use of sedation and intubation and information from four early time points (pre-hospital, arrival at the Accident and Emergency department, post-resuscitation, and arrival at the `neuro' unit) was combined to stratify the subjects as severe (58%), moderate (17%) or intermediate (19%). In 48% of patients classified the CT scan showed features of a `mass lesion' and in 40% showed a subarachnoid haemorrhage. Fifty-five centres provided the data on outcome for 94% of the cases recruited in these centres six months after injury. 31% died, 3% were vegetative, 16% severely disabled, 20% moderately disabled and 31% had made a good recovery. Comparison of the data from different parts of Europe showed differences in the frequency of secondary transfer, cause of injury, occurrence of major extracranial injury, CT scan findings, intracranial operation, clinical severity of injury and utilisation of the components of intensive care and the occurrence of a favourable outcome, although the latter difference was not statistically significant when variations in the initial severity of injury were taken into account.  The findings in the present survey are compared with newly analysed information for three previous large series: the International Data Bank involving the UK, the Netherlands and the USA, the North American Traumatic Coma Data Bank, and data from four centres in the UK. The comparisons showed substantial similarities and also differences that may reflect variations in policy for admission of the head injury to `neuro' units, and evolution in methods of assessment, investigation and management. The effects of these differences on outcome requires further, rigorous prospective study.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-6903
    Keywords: Na+−K+-ATPase ; freezing lesion ; brain edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper investigates the kinetic parameters of Na+−K+-ATPase in glial, neuronal, and synaptosomal enriched fractions isolated from rabbit cerebral cortex. Under normal conditions, kinetic parameters-Vmax and K 0.5 K+ -of Na+−K+-ATPase are the same in the three fractions, suggesting that this enzyme behaves as the same molecular entity. Following a cryogenic lesion, the alterations of these parameters appear to be different in the different fractions. These data suggest that the same enzyme exhibits various responses when exposed to the same pathological event. The dissimilar lipid composition of the Na+−K+-ATPase environment, and/or different adaptative responses to abnormal ion concentrations in glial, neuronal, and synaptosomal fractions could account for these different responses.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-6903
    Keywords: Cold-induced brain edema ; peroxidation ; superoxide dismutase ; catalase ; glutathione peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between free radicals reactions and the cell detoxifying system was investigated during the development of brain edema following a cryogenic lesion in the rabbit cerebral cortex. The amount of TBA-reactive material present six hours after freezing was less than in the controls, then increased at 48 and 96 hours. The activity of superoxide dismutase (SOD) decreased 6 hours post-injury; at the same time, we observed a stimulation of catalase activity. The glutathione peroxidase activity (GSH-Px) rose 96 hours post-lesion. The decrease of TBA-reactive products could result from an elimination rate that exceeds generation.
    Type of Medium: Electronic Resource
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