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  • 1
    Electronic Resource
    Electronic Resource
    Investigation of salt — Mixed solvent systems. XXXVII. Crystallization enthalpy of lithium chloride in mixed solvent systems (1990)
    Springer
    Journal of solution chemistry 19 (1990), S. 437-446 
    Details
    ISSN: 1572-8927
    Keywords: Acetone ; enthalpy of crystallization ; enthalpy of dissolution ; enthalpy of transition ; ion-solvent interaction ; lithium chloride ; methanol ; N,N-dimethylformamide ; solvation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The crystallization enthalpy of LiCl at 25°C in LiCl-H2O-cosolvent systems is determined calorimetrically as a function of the cosolvent content in the mixed solvent. This parameter is used for the investigation of heat phenomena accompanying the solvation of the salt in a saturated solution. The cosolvents employed include methanol, acetone, and N,N-dimethylformamide. The most pronounced change is effected by replacement of water with N,N-dimethylformamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00650376
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  • 2
    Electronic Resource
    Electronic Resource
    Investigations of salt — Mixed solvent systems XXXVIII. Crystallization enthalpy of magnesium chloride in mixed solvent systems (1990)
    Springer
    Journal of solution chemistry 19 (1990), S. 447-455 
    Details
    ISSN: 1572-8927
    Keywords: Acetone ; enthalpy of crystallization ; enthalpy of dissolution ; enthalpy of transition ; ion-solvent interaction ; magnesium chloride ; methanol ; N,N-dimethylformamide ; solvation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The crystallization enthalpies of MgCl2 in MgCl2−H2O-cosolvent systems at 25°C were determined calorimetrically as a function of the cosolvent content in the mixed solvent. Methanol, acetone, and N,N-dimethylformamide were employed as cosolvents. The results show the individual cosolvents to have very differently influences on the energy state of the salt in the saturated solution. The most pronounced changes are effected by an increase of the DMF content in the mixed solvent. The intensity of Mg2+-DMF interaction at a higher DMF content in the saturated solution considerably exceeds the Li+-DMF interaction in LiCl solutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00650377
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  • 3
    Electronic Resource
    Electronic Resource
    Enthalpy of crystallization of lithium chloride from aqueous solution at 25°C (1986)
    Springer
    Journal of solution chemistry 15 (1986), S. 269-282 
    Details
    ISSN: 1572-8927
    Keywords: Activity coefficients ; enthalpy of crystallization ; enthalpy of dissolution ; enthalpy of formation ; lithium chloride ; solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The enthalpies of crystallization of LiCl and LiCl·H2O from aqueous solutions at 25°C are reported as measured by a calorimetric method and derived from the previously published concentration dependence of the enthalpy of solution data. The results are compared with those obtained from the concentration dependence of activity coefficients and from the temperature dependence of solubilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00646695
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  • 4
    Electronic Resource
    Electronic Resource
    Olfactory neuroblastoma: Detection of genomic imbalances by comparative genomic hybridization (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 839-844 
    Details
    ISSN: 0942-0940
    Keywords: Olfactory neuroblastoma ; CGH ; molecular genetic abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Olfactory neuroblastoma (esthesioneuroblastoma) is a very rare tumour of the olfactory mucosa. Morphological features and cytogenetic studies strongly suggest a neuro-ectodermal origin. Up to now, cytogenetic studies are inconsistent. Some of them have proposed that the tumour belongs to the pPNET family. In the present study we describe genomic imbalances in olfactory neuroblastoma in a 46-year-old woman by using the molecular cytogenetic technique — comparative genomic hybridization (CGH) — in order to define the spectrum of genetic abnormalities in the tumour. The anatomical location and morphological findings were the basis for the diagnosis of esthesioneuroblastoma. Immunohistochemical reactions for NSE, synaptophysin, chromogranin A, HNK-l/Leu-7 and S-100 revealed a characteristic immunophenotype. The CGH analysis showed multiple changes including DNA overrepresentations of chromosomes 4. 8, 11 and 14, partial DNA gains of the long arms of chromosomes 1 and 17, deletions of the entire chromosomes 16, 18. 19 and X, and partial losses of chromosomes 5q and 17p. This study represents an early utilisation of the CGH technique in olfactory neuroblastoma and demonstrates that the tumour carries complex chromosomal aberrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411401
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  • 5
    Electronic Resource
    Electronic Resource
    Analyseprogramm zur quantitativen Erfassung chromosomaler Aberrationen mittels komparativer genomischer Hybridisierung (CGH)*** (1996)
    Springer
    Der Pathologe 17 (1996), S. 342-348 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Komparative genomische Hybridisierung ; CGH ; Bildanalyse ; FISH ; Key words Comparative genomic hybridization ; CGH ; Image analysis ; Tumour cytogenetics ; FISH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Comparative genomic hybridization (CGH) is a molecular cytogenetic method for the detection of chromosomal imbalances between a tumor and a normal genome. In order to produce quantitative and reproducible results, we developed an image analysis program that allows the detection and mapping of the genetic alterations. The result is represented as a CGH sum karyogram in which the genetic changes are documented as color coded-chromosomes. The aim of our investigation is to correlate the genotype with the phenotype on the basis of CGH sum karyograms and thus to achieve a genetic characterization that will supplement the morphological tumor description.
    Notes: Zusammenfassung Die komparative genomische Hybridisierung („comparative genomic hybridization“, CGH) ist ein molekularzytogenetisches Verfahren, welches die umfassende Analyse eines Tumorgenoms auf Über- und Unterrepräsentationen von DNA-Abschnitten ermöglicht. Um quantitative und reproduzierbare Aussagen über die genetischen Aberrationen machen zu können, wurde eine Software entwickelt, welche die objektive Erfassung von Ort und Art der Veränderungen ermöglicht. Das Ergebnis wird in Form eines CGH-Summenkaryogramms dargestellt, welches die genetischen Veränderungen als farbkodierte Chromosomen dokumentiert. Ziel dieser Untersuchungen ist es, auf der Grundlage von Summen-Karyogrammen eine Korrelation zwischen Genotyp und Phänotyp herzustellen und damit eine genetische Charakterisierung von Tumoren zu erreichen, die die morphologische Beschreibung ergänzt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050171
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  • 6
    Electronic Resource
    Electronic Resource
    Prevention of Age-Related Aneuploidies by Polar Body Testing of Oocytes (1999)
    Springer
    Journal of assisted reproduction and genetics 16 (1999), S. 165-169 
    Details
    ISSN: 1573-7330
    Keywords: preimplantation diagnosis ; chromosome 13, 18, and 21 aneuploidies ; FISH ; first and second polar bodies ; IVF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: We previously demonstrated that aneuploidy-free oocytes may be preselected by testing the first and second polar bodies removed from oocytes following their maturation and fertilization. The present paper describes the results of the application of the method in 659 in vitro fertilization cycles from patients of advanced maternal age. Methods: Using micromanipulation techniques, 3943 oocytes were tested by polar body sampling and fluorescent in situ hybridization analysis using specific probes for chromosomes 13, 18, and 21. Results: Fluorescent in situ hybridization results were available for 3217 (81.6%) of 3943 oocytes studied, of which 1388 (43.1%) had aneuploidies; 35.7% of the aneuploidies were of first meiotic division origin, and 26.1% of second meiotic division origin. Most errors in the first meiotic division were represented by chromatid malsegregation. The transfer of embryos deriving from 1558 of 1829 aneuploidy-free oocytes in 614 treatment cycles resulted in 131 clinical pregnancies and 88 healthy children born after confirmation of the polar body diagnosis. Conclusions: Polar body testing of oocytes provides an accurate and reliable approach for prevention of age-related aneuploidies in in vitro fertilization patients of advanced maternal age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020304621338
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