Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • CSF  (1)
  • Deiters' neurons  (1)
  • antiepileptic  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the mechanisms by which gamma-amino-butyric acid in association with phosphatidylserine exerts an antiepileptic effect in the rat (1992)
    Springer
    Neurochemical research 17 (1992), S. 1229-1233 
    Details
    ISSN: 1573-6903
    Keywords: GABA ; Phoshatidylserine ; antiepileptic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The i.p. injection in rats of GABA (740 mg/Kg) after sonication with an equal amount of phosphatidylserine (PS) has an antiepileptic effect. The injection of plain GABA has no such an effect. Blood, brain and synaptosomal accumulation of exogenous labeled GABA under the two circumstances are evaluated. In the case of GABA/PS injection there is a higher passage of the exogenous labeled neurotransmitter into the blood and brain nerve endings (synaptosomes). A higher synaptosomal accumulation of the exogenous labeled neurotransmitter is found even when GABA and PS are injected separately. Since these accumulation increases occur at a time when there is the antiepileptic effect, they seem relevant to it. Our interpretation of the chain of the events resulting in the antiepileptic action is that the phospholipid facilitates from the beginning the first passage of the exogenous neurotransmitter form the peritoneum to the blood. Then a higher passage to the brain tissue and eventually to the GABA-ergic nerve endings ensues. The brisker accumulation of the exogenous neurotransmitter in the nerve endings could be at the basis of a more efficient GABA-ergic inhibitory control in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968405
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function (1995)
    Springer
    Neurological sciences 16 (1995), S. 643-646 
    Details
    ISSN: 1590-3478
    Keywords: CSF ; Neurological diseases ; Macromolecules ; GABAA receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Campioni di liquido cefalo-rachidiano di pazienti analizzati per casi di sospette malattie neurologiche sono stati separati nella componente macromolecolare (Peso Molecolare 〉3000 Daltons) ed in quella delle piccole molecole (PM〈3000 Daltons). La c omponente macromolecolare è stata testata per la sua possibile interferenza con l'accumulo di36Cl−, stimolato dal GABA, in “microsacs” della corteccia cerebrale di ratto. Per molte patologie non è stata rilevata alcuna interferenza. Fanno eccezione i pochi (2) casi di morbo di Parkinson; in entrambi i casi vi è una chiara stimolazione dell'attività GABAergica. Quest' ultima indicazione sembra degna di ulteriori indagini.
    Notes: Abstract Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW〉3000 Daltons) and small molecule components (MW〈3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of36Cl− accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230915
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Further evidence for the presence ofγ-aminobutyric acidA (GABAA) receptors on the cytoplasmic side of deiters' membrane (1992)
    Springer
    Cellular and molecular neurobiology 12 (1992), S. 327-332 
    Details
    ISSN: 1573-6830
    Keywords: Deiters' neurons ; plasma membrane ; Cl− permeability ; cytoplasmic-sideγ-aminobutyric acid (GABAA) receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The permeation of labeled Cl− across single nerve membranes microdissected from rabbit Deiters' neurons was studied in a microchamber system. The in → out permeation of the ions was evaluated under control conditions and in the presence of either 10−6 M GABA or 10−6 M GABA plus 10−5 M bicuculline methiodide (BMI) on the membrane cytoplasmic side. 2. In 32 experiments, involving one animal each, at least two membranes served as controls and at least two others were studied with the addition of GABA. Within each experiment all the membranes were obtained from the same animal. 3. In an additional 10 experiments, involving one animal each, at least two membranes served as controls and at least two others were studied in the presence of GABA plus bicuculline methiodide on the membrane cytoplasmic side. 4. The data show that 10−6 M GABA on the Deiters' membrane cytoplasmic side stimulates Cl− permeation in → out by 42% (P = 0.0000001). When 10−5 M BMI was present together with GABA, no stimulation of Cl− in → out permeation occurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734933
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...