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  • 1
    Electronic Resource
    Electronic Resource
    Peripheral, visceral and body nitrogen balance of catabolic patients, without and with parenteral nutrition (1988)
    Springer
    Intensive care medicine 14 (1988), S. 212-216 
    Details
    ISSN: 1432-1238
    Keywords: Injury ; Amino acid ; Nitrogen balance ; TPN ; Interorgans flux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of major trauma and sepsis on skeletal muscle, central tissue and whole body nitrogen (N) metabolism was investigated in 5 patients before and during TPN (30 kcal, 0.30 g N kg-1 day-1). Fasting 3-methylhistidine (MEH) urinary excretion was elevated (407.9±67.6 μmol m-2 day-1), muscle and body N balances (NB) were markedly negative (-28.2±4.6 g m-2 day-1 and-15.7±3.1 g m-2 day-1), while central tissue NB was positive (13.0±2.4 g m-2 day-1). TPN effected a reduction in MEH excretion (261.8±27.5 mmol m-2 day-1-p〈0.05) and decreased the release of almost all amino acids from muscle tissue, some of them acting as catabolic markers. Muscle (-7.2±1.2 g m-2 day-1-p〈0.01) as well as body NB (-4.8±1.4 g m-2 day-1-p〈0.01) improved, whilst central tissue NB worsened, even though still positive (3.1±1.6 g m-2 day-1-p〈0.05). Gathering fasting and TPN data MEH excretion was significantly related to both body (r=0.89) and muscle (r=0.73) NB, that were highly related to each other (r=0.93), being muscle always worse than body NB. In conclusion, the anticatabolic activity of TPN is confirmed, although our setting did not achieve muscle NB, it was consistently improved and seems to be the major determinant of body NB, in contrast central NB and central N utilization (46.4%±5.4 vs 15.8%±8.4-p〈0.05) worsened.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717991
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  • 2
    Electronic Resource
    Electronic Resource
    Essential and non-essential amino acid requirement in injured patients receiving total parenteral nutrition (1988)
    Springer
    Intensive care medicine 14 (1988), S. 399-405 
    Details
    ISSN: 1432-1238
    Keywords: Injury ; TPN ; Nitrogen balance ; Amino acid profile ; Nitrogen vs amino acid requirement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The metabolic derangements of injury are known to influence nitrogen (N) requirements whilst less is known about individual amino acid (AA) requirements. This study was designed to investigate prospectively N vs AA requirement in 36 injured patients treated with total parenteral nutrition (TPN). The non-protein caloric input was 30 kcal kg-1 day-1 and three AA solutions were assessed containing the same AAs but in different proportion. Overall N intake was set at 0.35 g N kg-1 day-1 for solution A and B and 0.24 g N kg-1 day-1 for solution C. Solution B was similar to A, both being enriched in branched chain AAs (BCAA: 0.69 g kg-1 day-1 in B compared with 0.55 g kg-1 day-1 in A) while decreased in aromatic and sulphurated forms (1.75 times the normal need). Solution C was designed to maintain a daily input of BCAA similar to A (0.52 g kg-1 day-1) but with the supply of aromatic and sulphurated AA between solutions A and B, the supply of other AAs (lysine, theonine, histidine, arginine, glycine) being dependent on the selected N intake. For all the essential AAs the supply was always greater than normal allowances. Increasing BCAA over 0.55 g kg-1 day-1 did not improve N balance when N intake was 0.35 g kg-1 day-1, whilst nutrition with solution C was unable to maintain N balance. Moreover we found indirect evidence that this N intake, 0.52g kg-1 day-1 was more sparing than 0.37 g kg-1 day-1 of BCAA. N balance of the three groups suggests that injured patients need more than 0.24 g N kg-1 day-1 probably for non-essential AA synthesis. The study of plasma AA values support the increased non-essential N need in group C and allows us to suggest the proper AA composition of the overall optimal daily N intake (0.28–0.30 g N kg-1 day-1) in catabolic patients: BCAA about 0.5 g kg-1 day-1, phenylalanine, methionine, tryptophane, threonine and lysine from 2–3 to 5–10 times the normal allowance, the remainding N supply (about 0.14 g kg-1 day-1) should be made up from histidine, arginine, tyrosine, serine, proline, glycine, glutamic and aspartic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262896
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Vascular ataxic hemiparesis: A prospective clinical and CT study (1986)
    Springer
    Neurological sciences 7 (1986), S. 253-256 
    Details
    ISSN: 1590-3478
    Keywords: Ataxic hemiparesis ; capsula interna ; basis pointis ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'emiparesi atassica è un quadro clinico relativamente frequente in cui si associano deficit di moto e cerebellari dallo stesso lato. Uno studio prospettico condotto su 27 pazienti che presentavano questa sintomatologia a genesi vascolare conferma che le aree interessate in questa sindrome sono la regione capsulare (braccio posteriore e corona radiata) e la base superiore del ponte.
    Notes: Abstract Ataxic hemiparesis is a relatively frequent clinical syndrome in which motor and cerebellar deficits on the same side are associated. A prospective study conducted on 27 patients who displayed these vascular symptoms confirms that the areas crucial to the onset of this syndrome are the capsular region (posterior limb-corona radiata) and the upper basis pontis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230889
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Muscle CT, biopsy and EMG in diagnosis of neuromuscular diseases (1987)
    Springer
    Neurological sciences 8 (1987), S. 51-53 
    Details
    ISSN: 1590-3478
    Keywords: Neuromuscular diseases ; EMG ; muscle biopsy ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Il valore diagnostico dell' EMG e della biopsia muscolare viene confrontato con quello della TC muscolare in 53 pazienti affetti da malattie neuromuscolari. La TC muscolare concorda con la diagnosi clinica nel 62% delle miopatie, con un massimo nelle distrofie di Duchenne e nella miopatia scapolo-peroneale, mentre è di scarsa utilità nelle miopatie metaboliche ed infiammatorie. Nelle malattie neurogene la TC muscolare è in concordanza con la diagnosi clinica nel 63% dei casi, con un massimo nelle neuropatie acquisite.
    Notes: Abstract The diagnostic value of EMG and muscle biopsy has been compared with muscle CT in 53 patients with neuromuscular diseases. CT concordance with clinical diagnosis was found in 62% of myopathies and was highest in Duchenne PMD and scapulo-peroneal myopathy and very low in metabolic and inflammatory myopathies. In neurogenic diseases muscle CT agreed with clinical diagnosis in 63% of patients: the highest concordance was found in acquired polyneuropathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02361435
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    Paper (German National Licenses)
    Fulltext
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