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  • 1
    Electronic Resource
    Electronic Resource
    The onset of effect of the H1-antagonist acrivastine (“Semprex”) assessed by histamine bronchial challenge in volunteers (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 311-313 
    Details
    ISSN: 1432-1041
    Keywords: acrivastine ; H1-antagonist ; histamine bronchial challenge ; onset of effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The onset of effect of acrivastine, a new H1-antagonist, has been assessed using antagonism of histamine-induced bronchoconstriction in sensitive volunteers. Acrivastine administered 30, 45, 60 or 90 min before challenge produced a right-shift of the histamine dose-response curve of at least 8-fold indicating that a clinically desired degree of H1-antagonism was present within 30 min of ingestion of the recommended therapeutic dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315119
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Brain metastases from colon cancer (1983)
    Springer
    Journal of neuro-oncology 1 (1983), S. 203-209 
    Details
    ISSN: 1573-7373
    Keywords: brain ; metastasis ; brain metastasis ; colon cancer ; radiation therapy ; CT scans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior to neurologic presentation. The colon tumor was left-sided in 32; 32 had regional lymph node metastases at neurological presentation; 37 patients had extensive systemic metastasis as well as the brain lesion. Median survival from onset of therapy for brain metastasis was 9 weeks in 32 radiation therapy (RT) treated patients (range, 2–57 weeks), 37 weeks in 7 surgically resected patients (2–84 weeks), and 4 weeks (3.5 weeks) in 2 chemotherapy patients. Follow-up CT scans were improved in 2 of 11 radiated patients. Five of 6 surgically treated patients with CT follow-up demonstrated recurrent tumor (median 4 months). The prognosis for patients with brain metastasis in colon cancer is poor, regardless of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165604
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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