ISSN:
1432-1041
Keywords:
acrivastine
;
H1-antagonist
;
histamine bronchial challenge
;
onset of effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The onset of effect of acrivastine, a new H1-antagonist, has been assessed using antagonism of histamine-induced bronchoconstriction in sensitive volunteers. Acrivastine administered 30, 45, 60 or 90 min before challenge produced a right-shift of the histamine dose-response curve of at least 8-fold indicating that a clinically desired degree of H1-antagonism was present within 30 min of ingestion of the recommended therapeutic dose.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315119