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  • 1
    Electronic Resource
    Electronic Resource
    Effects of antidiuretic hormone on electrolyte reabsorption and secretion in distal tubules of rat kidney (1984)
    Springer
    Pflügers Archiv 401 (1984), S. 167-173 
    Details
    ISSN: 1432-2013
    Keywords: Brattleboro ; Antidiuretic hormone ; Calcitonin ; Parathyroid hormone ; Glucagon ; Electrolyte ; Micropuncture ; Electron probe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of (1-desamino-8-d-arginine) vasopressin (dDAVP) on water and electrolyte transport in the distal tubule were investigated by micropuncture. Since, in addition to antidiuretic hormone, parathyroid hormone, calcitonin and glucagon stimulate the adenylate-cyclase system in this nephron segment, experiments were performed on hormone-deprived rats, i.e. homozygous DI Brattleboro rats with reduced levels of endogenous parathyroid hormone, calcitonin and glucagon. Along the distal tubule, dDAVP enhanced water, Cl, Na and Ca reabsorption and sharply increased net K secretion. Phosphate transport was left unchanged and Mg reabsorption was not significantly altered by dDAVP between the early and late distal tubule. Antidiuretic hormone also slightly increased water filtration rate in the superficial nephron, which rose in proportion to whole kidney glomerular filtration rate. It is concluded that, in rats: 1) antidiuretic hormone stimulates water, NaCl and Ca absorption and enhances K secretion along the distal tubule and 2) the tubular effects of dDAVP on electrolyte transport in the loop and distal tubule are responsible for decreasing Mg and Ca urinary excretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583877
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stimulation by human calcitonin of electrolyte transport in distal tubules of rat kidney (1983)
    Springer
    Pflügers Archiv 399 (1983), S. 111-118 
    Details
    ISSN: 1432-2013
    Keywords: Calcitonin ; Distal tubule ; Micropuncture ; Electron-probe ; Brattleboro rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of human calcitonin (HCT) on the distal tubule were investigated by micropuncture in hormone-deprived rats, i.e. in the absence of parathyroid hormone, antidiuretic hormone and glucagon, which might have masked these effects. Two groups of rats were studied: hormone-deprived and hormone-deprived+HCT, infused at 1.0 mU/min\100 g b.w. In the urine, HCT markedly reduced Ca and Mg excretion whereas excretion of water, Na and K was not significantly affected. Along the distal tubule, HCT strongly enhanced Na, Cl, Mg, Ca and total solute reabsorption, decreased K secretion but did not alter water or phosphate transport. It is concluded that HCT stimulated Na, Cl, Ca and Mg reabsorption. If, as suggested, HCT also stimulated the reabsorptive component of K transport, the hormone should therefore elicit the same physiological effects in the distal tubule and the thick ascending limb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00663905
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glomerular filtration rate and microsphere distributions in single nephron of rat kidney (1975)
    Springer
    Pflügers Archiv 357 (1975), S. 291-301 
    Details
    ISSN: 1432-2013
    Keywords: Single Nephron ; Glomerular Filtration Rate ; Microsphere Distribution ; Microdissection ; Extra Cellular Fluid Volume Expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In control non diuretic (ND) and in salt-loaded (SL) rats, both the microsphere technique and the14C ferrocyanide infusion technique were used to determine the distribution of microspheres in single glomeruli and the SNGFR of the corresponding nephrons. A sample of microspheres with a diameter averaging 11.0±2.6 μ SD was selected from a 15±5 μ unlabelled batch. In each rat, three million of these microspheres were injected through the left carotid artery. The microspheres were directly counted under microscopic observation in the glomeruli of the nephrons which were microdissected to determine the SNGFR value. The number of microspheres per glomerulus for a given kidney generally varied from 0 to 8 and was independant to the SNGFR value. The diameter of the microspheres trapped was constant in all the animals. The mean number of microspheres for superficial (S) and juxtamedullary (JM) nephrons was, (ND):S=1.99±0.48 SE.,n=5; JM=3.02±0.51 SE,n=5;P〈0.02, (SL):S=3.75±0.53 SE,n=6; JM=2.86±0.33 SE,n=6;P〈0.05. This distribution was directly related to that of SNGFR in ND rats (S=39.0±6.1 SD and JM=49.5±10.3 nl/min) but not in SL rats (S=50.9±6.1 and JM=66.9±10.0 nl/min). In conclusion, the microsphere technique described in the present paper, appears more suitable for investigating single glomerular blood flow since the number and the size of the microspheres trapped are directly determined at the level of the glomerulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585983
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Intrarenal glomerular filtration rate distribution in salt loaded rats (1974)
    Springer
    Pflügers Archiv 349 (1974), S. 191-202 
    Details
    ISSN: 1432-2013
    Keywords: Single Nephron Glomerular Filtration Rate ; Superficial Nephrons ; Juxtamedullary Nephrons ; Ferrocyanide Ions ; Microdissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intrarenal SNGFR distribution was examined in rats undergoing extracellular fluid volume expansion using 1.14C ferrocyanide infusion technique, 2. Hanssen's technique, 3. Hanssen's technique after infusion of unlabelled ferrocyanide solution. The S/JM SNGFR ratios were respectively 0.74±0.12 S.D., 0.98±0.12 S.D., 0.95±0.12 S.D. in the three groups. Thus no SNGFR redistribution was found using the14C ferrocyanide infusion technique. In contrast, redistribution was observed using Hanssen's technique, both in the presence and absence of a previous ferrocyanide infusion. It was concluded that the presence of ferrocyanide ions at the macula densa site does not influence intrarenal SNGFR distribution. The authors suggest that the redistribution observed using Hanssen's technique results from the method used to inject the label.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592447
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    Paper (German National Licenses)
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