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  • 1
    Electronic Resource
    Electronic Resource
    Exercise-induced hypoglycaemia in IDDM patients treated with a short-acting insulin analogue (1995)
    Springer
    Diabetologia 38 (1995), S. 106-111 
    Details
    ISSN: 1432-0428
    Keywords: Exercise ; insulin analogue ; hypoglycaemia ; IDDM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to examine the effect of shortacting insulin analogue on the exercise-induced hypoglycaemia in insulin-dependent diabetes mellitus (IDDM) patients we compared the glycaemic response of 40 min cycle ergometer exercise performed either shortly (40 min) or later (180 min) after a breakfast meal and subcutaneous injection of either short-acting insulin analogue [Lys(B28) Pro(B29)] or soluble human insulin (Humulin Regular) in ten IDDM patients with long duration of the disease. Both preparations had been used 1 month before respective studies. Changes in blood glucose, insulin and counterregulatory hormones were assayed. As compared to human insulin, after the analogue injection the peak insulin concentration came earlier, was 56% higher (p〈0.05) and disappeared faster, and the postprandial blood glucose response was lower (p〈0.05). In the analogue-treated patients the exercise-induced hypoglycaemia was 2.2-fold greater (p〈0.01) during the early exercise, but 46% less (p〈0.05) during late exercise as compared to the treatment with human insulin. Serum insulin or analogue concentration at the beginning of the exercise correlated closely with the fall in blood glucose during exercise (r=0.74,p〈0.01;r=0.73,p〈0.02, respectively). In the analogue-treated patients, fasting serum glucagon and adrenalin concentrations were higher than during human insulin therapy (p〈0.05) and remained so throughout the study. As compared to soluble human insulin, a much faster absorption of insulin analogue: 1) reduces post-prandial hyperglycaemia, 2) can either augment or reduce exercise-induced hypoglycaemia depending on the time interval between insulin injection and the time of exercise. Since exercise in usually not performed until 2–3 h after a meal, short-acting insulin analogue may be more feasible than soluble human insulin for active IDDM patients. [Diabetologia (1995) 38: 106–111]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02369359
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nocturnal rise in markers of bone resorption is not abolished by bedtime calcium or calcitonin (1994)
    Springer
    Calcified tissue international 55 (1994), S. 349-352 
    Details
    ISSN: 1432-0827
    Keywords: Pyridinolines ; Type I collagen carboxyterminal telopeptide ; Osteoporosis ; Calcium ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract As assessed by urine pyridinium cross-links, bone resorption increases at night. This has been ascribed to either the nocturnal rise of serum parathyroid hormone (PTH) or immobilization. ICTP is the carboxyterminal telopeptide region of type I collagen in bone, cross-linked via pyridinium cross-links and liberated during the degradation of type I collagen. To study whether the nocturnal rise in bone resorption is seen also in serum type I collagen carboxyterminal telopeptide (ICTP) and whether this rise is abolished by bedtime calcium or calcitonin, nine healthy postmenopausal women participated in three 24 hour sessions. At 2200 hours, either 1 g of oral calcium or 200 IU of intranasal calcitonin or no treatment (control session) were given. The participants were recumbent from 2200 hours to 0600 hours. Like urinary pyridinolines, serum ICTP showed a clearcut nocturnal rise during the control session, increasing from 3.7±0.3 μg/liter (mean±SE) at 2000 hours to 4.9±0.4 μg/liter at 0600 hours (P〈0.001). Administration of calcium did not affect either serum ICTP or urinary pyridinolines, although it decreased serum intact PTH by 18% (P〈0.001) as assessed by areas under curve (AUC) after 2200 hours. Serum ICTP and urinary pyridinolines remained unchanged also after administration of calcitonin which increased the AUC for serum intact PTH by 9% (P〈0.05). In conclusion, serum ICTP follows a circadian rhythm in healthy postmenopausal women. The nocturnal rise in markers of bone resorption is not due to PTH, and its dependency on the function of osteoclasts is open to question.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299313
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    Paper (German National Licenses)
    Fulltext
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