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  • 1
    Electronic Resource
    Electronic Resource
    Exercise-induced hypoglycaemia in IDDM patients treated with a short-acting insulin analogue (1995)
    Springer
    Diabetologia 38 (1995), S. 106-111 
    Details
    ISSN: 1432-0428
    Keywords: Key words Exercise ; insulin analogue ; hypoglycaemia ; IDDM.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to examine the effect of short-acting insulin analogue on the exercise-induced hypoglycaemia in insulin-dependent diabetes mellitus (IDDM) patients we compared the glycaemic response of 40 min cycle ergometer exercise performed either shortly (40 min) or later (180 min) after a breakfast meal and subcutaneous injection of either short-acting insulin analogue [Lys(B28) Pro(B29)] or soluble human insulin (Humulin Regular) in ten IDDM patients with long duration of the disease. Both preparations had been used 1 month before respective studies. Changes in blood glucose, insulin and counterregulatory hormones were assayed. As compared to human insulin, after the analogue injection the peak insulin concentration came earlier, was 56 % higher (p 〈 0.05) and disappeared faster, and the postprandial blood glucose response was lower (p 〈 0.05). In the analogue-treated patients the exercise-induced hypoglycaemia was 2.2-fold greater (p 〈 0.01) during the early exercise, but 46 % less (p 〈 0.05) during late exercise as compared to the treatment with human insulin. Serum insulin or analogue concentration at the beginning of the exercise correlated closely with the fall in blood glucose during exercise (r = 0.74, p 〈 0.01; r = 0.73, p 〈 0.02, respectively). In the analogue-treated patients, fasting serum glucagon and adrenalin concentrations were higher than during human insulin therapy (p 〈 0.05) and remained so throughout the study. As compared to soluble human insulin, a much faster absorption of insulin analogue: 1) reduces post-prandial hyperglycaemia, 2) can either augment or reduce exercise-induced hypoglycaemia depending on the time interval between insulin injection and the time of exercise. Since exercise is usually not performed until 2–3 h after a meal, short-acting insulin analogue may be more feasible than soluble human insulin for active IDDM patients. [Diabetologia (1995) 38: 106–111]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050259
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Exercise-induced hypoglycaemia in IDDM patients treated with a short-acting insulin analogue (1995)
    Springer
    Diabetologia 38 (1995), S. 106-111 
    Details
    ISSN: 1432-0428
    Keywords: Exercise ; insulin analogue ; hypoglycaemia ; IDDM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to examine the effect of shortacting insulin analogue on the exercise-induced hypoglycaemia in insulin-dependent diabetes mellitus (IDDM) patients we compared the glycaemic response of 40 min cycle ergometer exercise performed either shortly (40 min) or later (180 min) after a breakfast meal and subcutaneous injection of either short-acting insulin analogue [Lys(B28) Pro(B29)] or soluble human insulin (Humulin Regular) in ten IDDM patients with long duration of the disease. Both preparations had been used 1 month before respective studies. Changes in blood glucose, insulin and counterregulatory hormones were assayed. As compared to human insulin, after the analogue injection the peak insulin concentration came earlier, was 56% higher (p〈0.05) and disappeared faster, and the postprandial blood glucose response was lower (p〈0.05). In the analogue-treated patients the exercise-induced hypoglycaemia was 2.2-fold greater (p〈0.01) during the early exercise, but 46% less (p〈0.05) during late exercise as compared to the treatment with human insulin. Serum insulin or analogue concentration at the beginning of the exercise correlated closely with the fall in blood glucose during exercise (r=0.74,p〈0.01;r=0.73,p〈0.02, respectively). In the analogue-treated patients, fasting serum glucagon and adrenalin concentrations were higher than during human insulin therapy (p〈0.05) and remained so throughout the study. As compared to soluble human insulin, a much faster absorption of insulin analogue: 1) reduces post-prandial hyperglycaemia, 2) can either augment or reduce exercise-induced hypoglycaemia depending on the time interval between insulin injection and the time of exercise. Since exercise in usually not performed until 2–3 h after a meal, short-acting insulin analogue may be more feasible than soluble human insulin for active IDDM patients. [Diabetologia (1995) 38: 106–111]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02369359
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Intramuscular triglyceride content is increased in IDDM (1998)
    Springer
    Diabetologia 41 (1998), S. 111-115 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Type 1 diabetes ; muscle ; triglycerides ; insulin sensitivity ; lipid oxidation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increased lipid oxidation is related to insulin resistance. Some of the enhanced lipid utilization may be derived from intramuscular sources. We studied muscle triglyceride (mTG) concentration and its relationship to insulin sensitivity in 10 healthy men (age 29 ± 2 years, BMI 23.3 ± 0.6 kg/m2) and 17 men with insulin-dependent diabetes mellitus (IDDM) (age 30 ± 2 years, BMI 22.8 ± 0.5 kg/m2, diabetes duration 14 ± 2 years, HbA1 c 7.7 ± 0.3 %, insulin dose 48 ± 3 U/day). Insulin sensitivity was measured with a 4 h euglycaemic (5 mmol/l) hyperinsulinaemic (1.5 mU or 9 pmol · kg–1· min–1) clamp accompanied by indirect calorimetry before and at the end of the insulin infusion. A percutaneous biopsy was performed from m. vastus lateralis for the determination of mTG. At baseline the IDDM patients had higher glucose (10.2 ± 0.9 vs 5.6 ± 0.1 mmol/l, p 〈 0.001), insulin (40.3 ± 3.2 vs 23.2 ± 4.2 pmol/l, p 〈 0.01), HDL cholesterol (1.28 ± 0.06 vs 1.04 ± 0.03 mmol/l, p 〈 0.01) and mTG (32.9 ± 4.6 vs 13.6 ± 2.7 mmol/kg dry weight, p 〈 0.01) concentrations than the healthy men, respectively. The IDDM patients had lower insulin stimulated whole body total (–25 %, p 〈 0.001), oxidative (–18 %, p 〈 0.01) and non-oxidative glucose disposal rates (–43 %, p 〈 0.001), whereas lipid oxidation rate was higher in the basal state ( + 44 %, p 〈 0.01) and during hyperinsulinaemia ( + 283 %, p 〈 0.05). mTG concentrations did not change significantly during the clamp or correlate with insulin stimulated glucose disposal. In healthy men mTG correlated positively with lipid oxidation rate at the end of hyperinsulinaemia (r = 0.75, p 〈 0.05). In conclusion: 1) IDDM is associated with increased intramuscular TG content. 2) mTG content does not correlate with insulin sensitivity in healthy subjects or patients with IDDM. [Diabetologia (1998) 41: 111–115]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050875
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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