ISSN:
1435-1463
Keywords:
Positron emission tomography
;
PET
;
Alzheimer's disease
;
(+) (R) N-11C-methyl nicotine
;
(−) (S) N-11C-methyl nicotine
;
brain
;
nicotinic receptors
;
cholinergic receptors
;
diagnostic marker
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02257652
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