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  • 1
    Electronic Resource
    Electronic Resource
    Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids (1994)
    Springer
    Diabetologia 37 (1994), S. 889-896 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; impaired glucose tolerance ; hypertriglyceridaemia ; hyperinsulinaemia ; non-esterified fatty acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although plasma insulin and triglyceride concentrations are positively correlated in many studies, the relationships between insulin resistance, insulin secretion and hypertriglyceridaemia remain unclear. To study these associations, subjects between the ages of 40 and 64 were randomly selected from a general practice register and invited to attend for a standard oral glucose tolerance test for measurement of insulin, triglyceride and non-esterified fatty acid concentrations. The study comprised 1122 subjects who were not previously known to have diabetes and who completed the test. Using the World Health Organisation criteria, 51 subjects were classified to have non-insulin-dependent diabetes mellitus, 188 had impaired glucose tolerance and 883 subjects had normal glucose tolerance. Triglyceride concentrations in subjects with glucose intolerance were elevated compared to those in control subjects, even after adjustment for age, obesity and gender (p〈0.001 for subjects with diabetes and p〈0.01 for those with impaired glucose tolerance compared to normal subjects). In separate multiple regression analyses for males and females, the most important determinants of the plasma triglyceride concentration were the area under the non-esterified fatty acid suppression curve (p〈0.001 in both genders) and the waist-hip ratio (p〈0.001 for men and 〈0.01 for women). The fasting insulin concentration was independently associated with triglyceride concentration in women only (p〈0.01). The most important determinant of the area under the non-esterified fatty acid suppression curve in men was the 30-min insulin increment, a measure of insulin secretion, (p〈0.001) whereas for women age (p〈0.001) and the body mass index (p〈0.01) were the most important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400944
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  • 2
    Electronic Resource
    Electronic Resource
    Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance (1995)
    Springer
    Diabetologia 38 (1995), S. 1358-1366 
    Details
    ISSN: 1432-0428
    Keywords: Key words Hypertriglyceridaemia ; non-esterified fatty acid ; ischaemic heart disease ; smoking.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subjects (389 men and 494 women) between 40 and 65 years of age were studied. Subjects were divided by gender into four groups according to 120-min glucose concentrations. Individuals in the highest quartile of glucose concentration had the highest mean triglyceride concentrations (p 〈 0.0001) and highest mean non-esterified fatty acid (NEFA) concentrations (p 〈 0.0001). There was also a clustering of cardiovascular risk factors normally associated with the insulin resistance syndrome in subjects in this group. Regression analysis showed that the most important determinants of triglyceride levels were smoking (men p = 0.001, women p = 0.005), waist:hip ratio (men p = 0.01, women p 〈 0.001) and NEFA suppression (men p = 0.02, women p = 0.005). NEFAs suppressed 16.7 % in women compared to 2.4 % in men during the first 30 min of the oral glucose tolerance test (p 〈 0.001). These results show that a clustering of cardiovascular risk factors associated with decreased NEFA suppression occurs in a sub-group of subjects with normal glucose tolerance and that the pattern of NEFA suppression differs between men and women. [Diabetologia (1995) 38: 1358–1366]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050435
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance (1995)
    Springer
    Diabetologia 38 (1995), S. 1358-1366 
    Details
    ISSN: 1432-0428
    Keywords: Hypertriglyceridaemia ; non-esterified fatty acid ; ischaemic heart disease ; smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subjects (389 men and 494 women) between 40 and 65 years of age were studied. Subjects were divided by gender into four groups according to 120-min glucose concentrations. Individuals in the highest quartile of glucose concentration had the highest mean triglyceride concentrations (p〈0.0001) and highest mean non-esterified fatty acid (NEFA) concentrations (p〈0.0001). There was also a clustering of cardiovascular risk factors normally associated with the insulin resistance syndrome in subjects in this group. Regression analysis showed that the most important determinants of triglyceride levels were smoking (men p=0.001, women p=0.005), waist:hip ratio (men p=0.01, women p〈0.001) and NEFA suppression (men p=0.02, women p=0.005). NEFAs suppressed 16.7% in women compared to 2.4% in men during the first 30 min of the oral glucose tolerance test (p〈0.001). These results show that a clustering of cardiovascular risk factors associated with decreased NEFA suppression occurs in a sub-group of subjects with normal glucose tolerance and that the pattern of NEFA suppression differs between men and women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401770
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  • 4
    Electronic Resource
    Electronic Resource
    Regulation of calcium-activated nonselective cation channel activity by cyclic nucleotides in the rat insulinoma cell line, CRI-G1 (1995)
    Springer
    The journal of membrane biology 145 (1995), S. 267-278 
    Details
    ISSN: 1432-1424
    Keywords: Rat insulinoma cell line, CRI-G1 ; Cyclic nucleotide regulation ; Calcium-activated nonselective cation channel ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The regulation of a calcium-activated nonselective cation (Ca-NS+) channel by analogues of cyclic AMP has been investigated in the rat insulinoma cell line, CRI-G1. The activity of the channel is modulated by cyclic AMP in a complex way. In the majority of patches (83%) tested concentrations of cyclic AMP of 10 μm and above cause an inhibition of channel activity which is immediately reversible on washing. In contrast, lower concentrations of cyclic AMP, between 0.1 and 1.0 μm, produce a transient activation of channel activity in most patches (63%) tested. One group of analogues, including N6-monobutyryl cyclic AMP and N6, 2′-O-dibutyryl cyclic AMP reduced the activity of the Ca-NS+ channel at all concentrations tested and 2′-O-Monobutyryl cyclic AMP produced inhibition in all patches tested except one, at all concentrations. A second group produced dual concentration-dependent effects on Ca-NS+, low concentrations stimulating and high concentrations inhibiting channel activity. 6-Chloropurine cyclic AMP and 8-bromo cyclic AMP produced effects similar to those of cyclic AMP itself. In contrast, 8-[4-chlorophenylthio] cyclic AMP also showed a dual action, but with a high level of activation at all concentrations tested up to 1mm. Ca-NS+ channel activity was also predominantly activated by low concentrations of Sp-cAMPS. The activating effects of both Sp-cAMPS and cyclic AMP are antagonized by Rp-cAMPS, which by itself only produced a weak inhibition of Ca-NS+ channel activity even at concentrations of 10 μm and above. The results are discussed in terms of a model in which cyclic AMP, and other cyclic nucleotides, modulate the activity of the Ca-NS+ channel by binding to two separate sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232718
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  • 5
    Electronic Resource
    Electronic Resource
    Nucleotide regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1 (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 101-112 
    Details
    ISSN: 1432-1424
    Keywords: Rat insulinoma cell line ; CRI-G1 ; Nucleotide regulation ; Calcium-activated nonselective cation channel ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The nucleotide regulation of a calcium-activated nonselective cation (Ca-NS+) channel has been investigated in the rat insulinoma cell line CRI-G1. The activity of the channel is reduced by both AMP and ADP (1–100 μm) in a concentration-dependent manner, with AMP being more potent than ADP. At lower concentrations (0.1–5 μm), both ADP and AMP activate the channel in some patches. Examination of the nucleotide specificity of channel inhibition indicates a high selectivity for AMP over the other nucleotides tested with a rank order of potency of AMP 〉 UMP 〉 CMP ≥GMP. Cyclic nucleotides also modulate channel activity in a complex, concentration-dependent way. Cyclic AMP exhibits a dual effect, predominantly increasing channel activity at low concentrations (0.1–10 μm) and reducing it at higher concentrations (100 μm and 1 mm). Specificity studies indicate that the cyclic nucleotide site mediating inhibition of channel activity exhibits a strong preference for cyclic AMP over cyclic GMP, with cyclic UMP being almost equipotent with cyclic AMP. Cyclic IMP and cyclic CMP are not active at this site. The cyclic nucleotide site mediating activation of the channel shows much less nucleotide specificity than the inhibitory site, with cyclic AMP, cyclic GMP and cyclic IMP being almost equally active.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238244
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    Paper (German National Licenses)
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