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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 31 (1973), S. 109-120 
    ISSN: 1432-0738
    Keywords: Alkaline Phosphatase ; Enzyme Induction ; Clotrimazole ; Phenobarbital ; Phenylbutazone ; Drug-Induced Changes in Liver Cells ; Histochemistry ; Endoplasmatic Reticulum ; Alkalische Phosphatase ; Enzyminduktion ; Clotrimazol ; Phenobarbital ; Phenylbutazon ; Arzneimittelinduzierte Hepatocytenveränderungen ; Histochemie ; Endoplasmatisches Reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Behandlung mit verschiedenen, mikrosomale Leber-enzyme induzierenden Pharmaka (Clotrimazol, Phenobarbital, Phenylbutazon) führte zu einem Aktivitätsanstieg der alkalischen Phosphatase im Blutplasma von Beagle-Hunden, der mit einer Vermehrung des Enzyms in der Leber einherging. Biochemische sowie licht- und elektronenmikroskopische Untersuchungen erbrachten keinen Hinweis auf das Vorhandensein einer intrahepatischen Cholestase, einer anderen Leberzellschädigung oder einer Beeinträchtigung des Skelettsystems. Die Aktivitätszunahme der alkalischen Phosphatase wird deshalb auf eine arzneimittelinduzierte, vermehrte de novo-Synthese in den Hepatocyten zurückgeführt.
    Notes: Abstract Treatment with different drugs inducing microsomal liver enzymes (clotrimazole, phenobarbital, phenylbutazone) produced an elevation of alkaline phosphatase in the plasma of Beagle dogs. It also caused an increase of the enzyme in the liver. Biochemical tests, light- and electron-microscope investigations gave no evidence of intrahepatic cholestasis, any other liver cell damage or impairment of the skeletal system. Therefore the rise of alkaline phosphatase activity was interpreted as a drug-induced increase of de-novo synthesis in the hepatocytes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 217 (1974), S. 377-382 
    ISSN: 1432-0711
    Keywords: Candida ; Candida and Squamous Epithelium ; Ultrastructural Investigation ; Antimycotic Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Sproßpilze dringen im infizierten Gewebe mehrere Zellagen tief vor. Zumindest in oberflächlichen Zellagen ist ein aktives Eindringen in einzelne Wirtszellen möglich. Im Inneren morphologisch intakter Epithelzellen kann eine Vermehrung der Erreger erfolgen. Darüber hinaus können die Pilze die Epithelzelle verlassen, ohne eine sichtbare Zellwandperforation zu hinterlassen. Einzelne Epithelzellen beherbergten bis zu 30 Sproßzellen.
    Notes: Summary This investigation demonstrates the behavior of pathogenic fungi on squamous epithelium by normal and electron microscopical means. The aim was to gather more information about the relationship of fungi and hosttissue. It could be shown that the infectious agent penetrates several layers of the infected tissue. Active penetration into individual hostcells is possible, at least in superficial layers. Inside of morphologically intact epithelial cells reproduction of the fungi is possible. In addition fungi can leave epithelial cells without visible perforation of the cell membrane. Individual epithelial cells host up to 30 cells of fungi. The inter and intraepithelial position of pathogenic fungi is emphasized with regard to antimycotic therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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