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  • 1
    Electronic Resource
    Electronic Resource
    Induction of light hydrocarbon nephropathy by p-dichlorobenzene (1988)
    Springer
    Archives of toxicology 61 (1988), S. 433-439 
    Details
    ISSN: 1432-0738
    Keywords: Alpha2μ-globulin ; Nephrotoxicity ; Nephrocarcinogenicity ; Male Fischer 344 rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to clarify the etiology of a dose-related increase in the incidence of tubular cell adenocarcinomas of the kidney in male rats, the nephrotoxicity of p-dichlorobenzene (p-DCB) was investigated in a subchronic study. Groups of ten male and ten female Fischer 344 rats were dosed by gavage with 0 (controls), 75, 150, 300 or 600 mg p-DCB/kg/day in corn oil. Half of the animals were sacrificed after 4 weeks and the remainder after 13 weeks. Increased urinary LDH and epithelial cell excretion and exacerbation of hyaline droplet accumulation in the cytoplasm of renal cortical cells were observed in male rats over the entire dose range investigated. Tubular single cell necrosis, dilated tubules with granular cast formation in the outer zone of the medulla, were evident in male rats after 4 and 13 weeks of treatment with doses of 150–600 mg/kg/day. In female rats there was no indication of a nephrotoxic action of p-DCB. The effects on the kidney, both in their morphological characteristics and the fact that they occur exclusively in male animals, correspond to the light hydrocarbon nephropathy observed as a result of short-term treatment with a number of aliphatic and cyclic hydrocarbons. The development of cortical renal tumors seems to be associated with this kind of kidney damage which is unique to male rats. The literature on this subject generally regards these renal effects as not predictive for man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293688
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Das Verhalten von Sproßpilzen am nicht verhornenden Plattenepithel (1974)
    Springer
    Archives of gynecology and obstetrics 217 (1974), S. 377-382 
    Details
    ISSN: 1432-0711
    Keywords: Candida ; Candida and Squamous Epithelium ; Ultrastructural Investigation ; Antimycotic Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Sproßpilze dringen im infizierten Gewebe mehrere Zellagen tief vor. Zumindest in oberflächlichen Zellagen ist ein aktives Eindringen in einzelne Wirtszellen möglich. Im Inneren morphologisch intakter Epithelzellen kann eine Vermehrung der Erreger erfolgen. Darüber hinaus können die Pilze die Epithelzelle verlassen, ohne eine sichtbare Zellwandperforation zu hinterlassen. Einzelne Epithelzellen beherbergten bis zu 30 Sproßzellen.
    Notes: Summary This investigation demonstrates the behavior of pathogenic fungi on squamous epithelium by normal and electron microscopical means. The aim was to gather more information about the relationship of fungi and hosttissue. It could be shown that the infectious agent penetrates several layers of the infected tissue. Active penetration into individual hostcells is possible, at least in superficial layers. Inside of morphologically intact epithelial cells reproduction of the fungi is possible. In addition fungi can leave epithelial cells without visible perforation of the cell membrane. Individual epithelial cells host up to 30 cells of fungi. The inter and intraepithelial position of pathogenic fungi is emphasized with regard to antimycotic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668025
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Funktionell-morphologische Untersuchungen zur arzneimittel-induzierten Hyperphosphatasämie bei Beagle-Hunden (1973)
    Springer
    Archives of toxicology 31 (1973), S. 109-120 
    Details
    ISSN: 1432-0738
    Keywords: Alkaline Phosphatase ; Enzyme Induction ; Clotrimazole ; Phenobarbital ; Phenylbutazone ; Drug-Induced Changes in Liver Cells ; Histochemistry ; Endoplasmatic Reticulum ; Alkalische Phosphatase ; Enzyminduktion ; Clotrimazol ; Phenobarbital ; Phenylbutazon ; Arzneimittelinduzierte Hepatocytenveränderungen ; Histochemie ; Endoplasmatisches Reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Behandlung mit verschiedenen, mikrosomale Leber-enzyme induzierenden Pharmaka (Clotrimazol, Phenobarbital, Phenylbutazon) führte zu einem Aktivitätsanstieg der alkalischen Phosphatase im Blutplasma von Beagle-Hunden, der mit einer Vermehrung des Enzyms in der Leber einherging. Biochemische sowie licht- und elektronenmikroskopische Untersuchungen erbrachten keinen Hinweis auf das Vorhandensein einer intrahepatischen Cholestase, einer anderen Leberzellschädigung oder einer Beeinträchtigung des Skelettsystems. Die Aktivitätszunahme der alkalischen Phosphatase wird deshalb auf eine arzneimittelinduzierte, vermehrte de novo-Synthese in den Hepatocyten zurückgeführt.
    Notes: Abstract Treatment with different drugs inducing microsomal liver enzymes (clotrimazole, phenobarbital, phenylbutazone) produced an elevation of alkaline phosphatase in the plasma of Beagle dogs. It also caused an increase of the enzyme in the liver. Biochemical tests, light- and electron-microscope investigations gave no evidence of intrahepatic cholestasis, any other liver cell damage or impairment of the skeletal system. Therefore the rise of alkaline phosphatase activity was interpreted as a drug-induced increase of de-novo synthesis in the hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310389
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  • 4
    Electronic Resource
    Electronic Resource
    Licht- und elektronenmikroskopische Untersuchungen mastigoter und amastigoter Formen von Trypanosoma cruzi unter dem Einfluß von Lampit® (1973)
    Springer
    Parasitology research 41 (1973), S. 255-267 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Vergleichende licht- und elektronenmikroskopische Untersuchungen haben folgende für die Wirkung von Lampit wichtige Ergebnisse gebracht: Alle beobachteten Veränderungen treten bei beiden Entwicklungsformen von Trypanosoma cruzi, bei den mastigoten wie auch bei den amastigoten Formen in sehr ähnlicher Ausprägung auf. Diese Veränderungen betreffen vorwiegend Mitochondrien, Kerne und Ribosomen und schreiten vom 1. bis zum 3. Tag während der Behandlung fort. Sie führen unter unseren Versuchsbedingungen bei der überwiegenden Zahl von Parasiten zu einer irreversiblen Schädigung.
    Notes: Summary Structural alterations of the mastigote and amastigote stages of Trypanosoma cruzi after treatment with Lampit® have been demonstrated by light and electron microscopy. The morphological changes of these two developmental forms are very similar. During the day 1 to 3 of the treatment severe structural alterations of the mitochondria, the nucleus and the ribosomes can be observed. Under the experimental conditions the majority of the parasites were irreversibly damaged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00348579
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    Paper (German National Licenses)
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