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  • Capsaicin  (2)
  • Capsaicin-sensitive  (1)
  • Dorsal root ganglion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The effect of capsaicin on afferent nerves and temperature regulation of mammals and birds
    Amsterdam : Elsevier
    Journal of Thermal Biology 11 (1986), S. 95-100 
    Details
    ISSN: 0306-4565
    Keywords: Capsaicin ; desensitization ; hypothalamic neurones ; nociception ; sensory neurones ; substance P ; temperature reception ; temperature regulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4565(86)90026-4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Efferent functions of C-fiber nociceptors (1998)
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. S8 
    Details
    ISSN: 0340-1855
    Keywords: Key words ; Antidromic vasodilatation ; axon reflex ; flare reaction ; plasma extravasation ; substance P ; calcitonin gene-related peptide ; galanin ; capsaicin ; fibromyalgia ; Schlüsselwörter ; Antidrome Vasodilatation ; Axonreflex ; Flarereaktion ; Plasmaextravasation ; Substanz P ; Calcitonin Gene-Related Peptide ; Galanin ; Capsaicin ; Fibromyalgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung C-Faser Nozizeptoren haben neben ihrer afferenten auch lokale efferente Funktionen, wie Vasodilatation, Plasmaextravasation und die Modulation neuronaler Aktivität, die durch Freisetzung der Neuropeptide Substanz P, Neurokinin A und Calcitonin Gene-Related Peptide (CGRP) an der peripheren Endigung ausgelöst werden. In der Haut der Säugetiere (einschließlich Mensch) ist CGRP der wichtigste Mediator der Flarereaktion. Die Vasodilatation wird beim Schwein durch Aktivierung von spezifischen Hitzenozizeptoren induziert. Bei der Taube wird die antidrome Vasodilatation durch intrinsisch freigesetztes Galanin gehemmt. Plasmaextravasation kann beim Schwein in Hautblasen und mit der Mikrodialyse durch Histaminsuperfusion, nicht aber durch elektrische Stimulation und Capsaicin, ausgelöst werden. Die neurogene Komponente der Histaminantwort (64%) wird durch NK2-Rezeptoren vermittelt und kann durch CGRP moduliert werden. Die genannten Neuropeptide können zur Sensibilisierung und unter bestimmten Bedingungen zur Stimulation von Nozizeptoren führen. Die erhöhte Sensitivität der Flarereaktion bei Fibromyalgiepatienten deutet auf eine veränderte Funktion der C-Faser Nozizeptoren hin.
    Notes: Summary C-fiber nociceptors not only serve afferent but also local efferent functions. The local efferent functions, such as vasodilatation, axon reflex flare reaction, plasma extravasation, and modulation of neuronal activity, are mediated via a local release of substance P, neurokinin A, and calcitonin gene-related peptide (CGRP) from the peripheral ending. CGRP is the main mediator of the capsaicin-induced flare reaction in the mammalian skin (including humans). In the pig skin the vasodilatation is due to activation of specific heat nociceptors. In the pigeon, antidromic vasodilatation is markedly inhibited by intrinsic galanin. Plasma extravasation in the pig skin blister base or using microdialysis can be evoked by histamine, but not by electrical stimulation or capsaicin. The neurogenic component of the histamine response (64%) appears to be mediated via NK2 receptors and can be modulated by CGRP. There is some evidence that the neuropeptides can also sensitize or stimulate nociceptors. Since in the fibromyalgia syndrome an increased sensitivity of the flare reaction has been observed, the hyperalgesia might be partly due to altered functions of C-fiber nociceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050226
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of the neurogenic inflammatory response by lidocaine in rat skin (1996)
    Springer
    Inflammation research 45 (1996), S. 10-13 
    Details
    ISSN: 1420-908X
    Keywords: Sensory nerves ; Neurogenic inflammation ; Lidocaine ; Capsaicin-sensitive ; Skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Axon reflex vasodilatation and neurogenic plasma extravasation are characteristic cutaneous vascular responses mediated by neuropeptides released from stimulated capsaicin-sensitive sensory nerve endings. Intracutaneous injections of local anaesthetics inhibit the axon-reflex flare elicited by chemical irritants in human skin. Results of earlier reports on the effects of local anaesthetics on neurogenic plasma extravasation are controversial. The aim of the present study, therefore, was to re-examine the effect of the local anaesthetic lidocaine on the neurogenic inflammatory response of rat skin. The effects of lidocaine on cutaneous inflammatory reactions were measured quantitatively by means of the Evans blue technique. Intracutaneous injection of lidocaine resulted in a dose-dependent inhibition of the neurogenic inflammation elicited by mustard oil and of the dye leakage response to compound 48/80 or histamine. It is suggested that the site of this inhibition is beyond the sensory nerve terminal, presumably at the level of the vascular endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263498
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dendrotoxin: a selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones (1986)
    Springer
    Pflügers Archiv 407 (1986), S. 365-369 
    Details
    ISSN: 1432-2013
    Keywords: Dendrotoxin ; Potassium channel ; Tetraethylammonium ; 3,4-Diaminopyridine ; Dorsal root ganglion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The voltage clamp technique was used to study the effects of dendrotoxin (DTX) on outward potassium currents in internally perfused dorsal root ganglion neurones of guinea-pig. Sodium currents were eliminated by tetrodotoxin (TTX, 2 μmol/l), calcium currents and calcium-activated potassium conductances were abolished by intracellular perfusion of cells with KF. 2. Depolarizing voltage shifts from a holding potential of −90 mV yielded a fast transient outward current (I K f ) and a delayed non-inactivating outward current (I K/s). These currents could be separated by shifting the membrane potential to −50 mV, whereI K f was almost completely inactivated. 3. DTX, at concentrations of 0.14–1.4 nmol/l selectively reduced a portion of the non-inactivating potassium current, leaving the transient outward current unaffected. Once manifested, the action of DTX could not be reversed by washing. 4. The I–V characteristic of the current blocked by DTX is almost linear and quite different from the one of the ‘DTX-resistant’ portion ofI K s , which shows a non-linear I–V curve. 5. Tetraethylammonium (TEA, 30 mmol/l) strongly reducedI K f andI K s . However, subsequent application of DTX was still able to further reduceI K s . 6. 3,4-diaminopyridine (3,4-DAP, 500 μmol/l) unselectively reducedI K f and a portion ofI K s . The remainder of the latter could not further be reduced by DTX, suggesting a similar action of the two blockers on non-inactivating potassium currents. 7. From the results presented, it is suggested that dendrotoxin selectively blocks a non-inactivating subtype of potassium channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652619
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    Paper (German National Licenses)
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