ISSN:
1433-8580
Keywords:
Carbohydrate metabolism
;
Glucose
;
Fructose
;
Intestinal mucosa
;
Liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The adaptive response of a diet containing 60% fructose on the activity of those enzymes which are involved in the metabolism of fructose was measured in the liver and in the jejunal mucosa of rats over a period of 12 days. Control animals received isocaloric amounts of glucose or starch. Under fructose feeding there was a marked increase in the activity of fructose-1-phosphate aldolase (3-fold), ketohexokinase (2–3-fold), and triokinase (3-fold) in the jejunal mucosa. In the liver, however, a significant increase in enzyme activity could only be seen for triokinase (2–3-fold), whereas the activity of the other enzymes measured were only slightly or not at all altered. The activity of the three enzymes mentioned above were elevated to a maximum within 3 days after feeding the fructose diet. In the following time of observation no major further changes occurred. The results show that fructose feeding in comparison to a glucose or starch containing diet leads to a marked adaptive increase in the activity of those enzymes, which are involved in the breakdown of fructose, only in the jejunal mucosa.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01856758
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