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  • Ulcerative colitis  (3)
  • Malignancy grading  (2)
  • Carcinoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Mucosal dysplasia and DNA content in ulcerative colitis patients with ileorectal anastomosis (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 566-571 
    Details
    ISSN: 1530-0358
    Keywords: Dysplasia ; DNA aneuploidy ; Ulcerative colitis ; Ileorectal anastomosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a follow-up study of an epidemiologically defined patient group comprising 1,274 patients with ulcerative colitis diagnosed in Stockholm County during 1955–1979, 55 patients had undergone colectomy with ileorectal anastomosis (IRA). Nine of these were found to have Crohn's disease after histopathologic review of the colectomy specimens. Of the 46 patients with ulcerative colitis remaining for evaluation, two died postoperatively. Twenty-five patients were subsequently reoperated with rectal excision owing to intractable inflammatory activity (n=22, one postoperative death) or owing to dysplasia (n=3). Of 19 patients with their IRA still intact at time of follow-up, 15 patients (median disease duration 23 years) had a flexible sigmoidoscopy with multiple biopsies performed. The average length of the remaining rectum and sigmoid colon was 26 cm. No patient had findings of dysplasia, carcinoma, or DNA aneuploidy. None of the four remaining patients had developed dysplasia or carcinoma at the time of the latest regular rigid sigmoidoscopy. The risk of malignant transformation in this selected group of patients with ulcerative colitis operated upon with colectomy and IRA derived from an epidemiologically defined population seems to be low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049896
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  • 2
    Electronic Resource
    Electronic Resource
    Dysplasia and DNA aneuploidy in a pelvic pouch (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 280-284 
    Details
    ISSN: 1530-0358
    Keywords: Pelvic pouch ; Ulcerative colitis ; Dysplasia ; DNA aneuploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with an 18-year history of ulcerative colitis was operated on with colectomy, mucosal proctectomy, ileoanal anastomosis, and an S-type pelvic pouch due to intractable chronic continuous disease. The patient was followed by endoscopic controls and biopsy sampling from the pouch at regular intervals. A gradual development of severe atrophy in the ileal mucosa was followed by the development of low grade dysplasia. At the most recent endoscopic control, 4 years after the construction of the pouch, biopsies were sampled also for flow cytometric DNA analyses. DNA aneuploidy was detected in a biopsy from the center of the pouch, and a biopsy taken immediately adjacent showed low grade dysplasia. These findings underline the importance of endoscopic follow-up after construction of a pelvic pouch and focus attention to the potential of malignant transformation of the mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02090171
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Highly malignant carcinoma in chronic ulcerative colitis without preceding dysplasia or DNA aneuploidy (1992)
    Springer
    Diseases of the colon & rectum 35 (1992), S. 82-86 
    Details
    ISSN: 1530-0358
    Keywords: Carcinoma ; Ulcerative colitis ; Sialomucin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 41-year-old female with a history of total ulcerative colitis for 15 years is presented. After eight years, she was enrolled in a colonoscopic surveillance program with regular examinations every second year and with biopsy sampling for histologic assessment of dysplasia as well as for flow cytometric analysis. Neither dysplasia nor DNA aneupoloidy developed during the course of the follow-up, but, after seven years, the patient developed a rapidly growing malignant stricture in the lower rectum. At the time of diagnosis, a local gluteal metastasis was found. Following preoperative radiation therapy, laparotomy disclosed a rectal cancer with local growth in the pelvis. Despite an attempt to perform curative surgery, the patient deteriorated and died within four months after the diagnosis. The carcinoma was of a poorly differentiated, mucinous, signet ring cell type, and DNA analyses of both the tumor and its metastases were diploid. Retrospective analyses of mucin content in colonoscopic biopsies showed a gradual shift from sulfated mucin to sialomucin. This case underlines the fact that even rigorous followups offer no absolute guarantee against incurable malignancy in surveillance programs for ulcerative colitis despite the inclusion of DNA analyses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02053345
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  • 4
    Electronic Resource
    Electronic Resource
    Quantitative flow-microfluorometric analysis of the DNA in cells from neoplasms of the urinary bladder: Correlation of aneuploidy with histological grading and the cytological findings (1978)
    Springer
    Urological research 6 (1978), S. 201-205 
    Details
    ISSN: 1434-0879
    Keywords: DNA-analysis ; Bladder neoplasms ; Malignancy grading ; Aneuploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The total DNA content in single cells from bladder washingtons of patients with tumours in the bladder has been analysed by means of a rapid-flow cytofluorometer. The frequency of occurrence of aneuploid cell populations has been related to the cytological findings and the histological grading according to Bergkvist et al. The frequency of occurrence of aneuploid cell populations in 228 patients increased from 7% for tumours of grades 0 and 1 to 79% for grade III tumours. In cell material cytologically classed as benign the frequency of occurrence was 8% increasing to 96% for poorly differentiated carcinomas. In patients with tumours of histological grade II, subdivided into one group with minor atypical features with no invasion and one with major deviation from the normal cell picture and suspected or manifest invasion, the frequencies of occurrence of aneuploidy were 9% and 68% respectively. The degree of aneuploidy has been determined by comparison of the position of the DNA values in relation to the normal DNA values. In 54 irradiated patients with persistent or recurrent tumours the position of the aneuploid cell lines changed in the diploid direction in comparison with that for 65 non-irradiated patients for the majority of which the aneuploid cell lines were in the tritetraploid region. The biological significance of the different degrees of aneuploidy is as yet unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262618
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The role of exfoliative cytology in the management of bladder carcinoma (1978)
    Springer
    Urological research 6 (1978), S. 197-200 
    Details
    ISSN: 1434-0879
    Keywords: Exfoliative cytology ; Bladder neoplasms ; Malignancy grading
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytological analyses of bladder washings from 974 patients with disorders of the urinary tract are reported. The cytological findings were compared with the clinical and histological diagnoses. The histological grading of bladder tumours was based on the classification proposed by Bergkvist et al. No false positive diagnosis of malignancy was made in the 320 patients without tumour growth. The five cases with positive cytology had histologically verified carcinoma in situ. The frequency of cytological diagnosis of cancer increased with the histological grade of malignancy in the 428 patients with bladder neoplasm. Carcinoma was graded in smears according mainly to the degree of epithelial atypia. A comparison with the histological grading was attempted. Of 226 cases of bladder carcinoma treated with supervoltage irradiation, 108 had persistence or recurrence of carcinoma. The clinical diagnosis was cytologically confirmed in 92 per cent of these cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262617
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    Paper (German National Licenses)
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