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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic study of IV infusions of adriamycin (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 205-212 
    Details
    ISSN: 1432-1041
    Keywords: adriamycin ; cancer patients ; infusion ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31–85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a more than 3-fold individual variation. The pharmacokinetics of adriamycin was linear. There was no pharmacokinetic rational for variation of the dose with the age of the patients. There was good agreement between the measured plasma concentration-time curves for prolonged infusions and curves predicted from pharmacokinetic data from short term infusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609693
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The role of exfoliative cytology in the management of bladder carcinoma (1978)
    Springer
    Urological research 6 (1978), S. 197-200 
    Details
    ISSN: 1434-0879
    Keywords: Exfoliative cytology ; Bladder neoplasms ; Malignancy grading
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytological analyses of bladder washings from 974 patients with disorders of the urinary tract are reported. The cytological findings were compared with the clinical and histological diagnoses. The histological grading of bladder tumours was based on the classification proposed by Bergkvist et al. No false positive diagnosis of malignancy was made in the 320 patients without tumour growth. The five cases with positive cytology had histologically verified carcinoma in situ. The frequency of cytological diagnosis of cancer increased with the histological grade of malignancy in the 428 patients with bladder neoplasm. Carcinoma was graded in smears according mainly to the degree of epithelial atypia. A comparison with the histological grading was attempted. Of 226 cases of bladder carcinoma treated with supervoltage irradiation, 108 had persistence or recurrence of carcinoma. The clinical diagnosis was cytologically confirmed in 92 per cent of these cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262617
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Radiation treatment of urinary bladder carcinoma (1978)
    Springer
    Urological research 6 (1978), S. 229-232 
    Details
    ISSN: 1434-0879
    Keywords: Irradiation ; Bladder carcinoma ; Superfractionation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 602 patients with verified urinary bladder cancer have been treated with full irradiation in the period 1957–1970. As expected, the survival rate decreased with increasing stage of the tumour. Another group was randomized and treated according to either of two fractionation schemes. This trial started in 1971 and shows that there is increased survival and tumour clearance rate with superfractionation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262624
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Prediction of survival and recurrence in bladder carcinoma (1982)
    Springer
    Urological research 10 (1982), S. 109-113 
    Details
    ISSN: 1434-0879
    Keywords: Bladder carcinoma ; Recurrence prediction ; Urine cytology ; Tumour grade ; Urinary carcinoembryonic antigen ; Classification ; Survial prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have followed a large population of patients receiving radiation treatment for bladder carcinoma with respect to survival and recurrence-free survival. Bivariate and multivariate life table analyses have been performed using a set of independent variables. The most important were T class, grade (G), urinary carcinoembryonic antigen (U-CEA) taken before treatment and cytological analysis 4 months after treatment. We compared the usual way of classifying a patient (T+G) with the combination of U-CEA and cytology since the latter two variables seemed to have great prognostic importance. The analyses show that T+G gives the best significance for survival (P=0.0003) while U-CEA and cytology is better for recurrence-free survival (ρ=0.0002). 0.0002).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255951
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Possibilities for an extended classification of bladder cancer (1984)
    Springer
    Urological research 12 (1984), S. 195-197 
    Details
    ISSN: 1434-0879
    Keywords: Bladder cancer ; Carcinoembryonic antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with bladder cancer were evaluated for T-class, histo-pathological grade and U-CEA (urinary carcinoembryonic antigen) before treatment and the cytological picture 4 months after treatment. Previous work has shown that these variables are not significantly intercorrelated. Scores were computed, consisting of the sums of these (dichotomized) variables. In a statistical analysis with the life-table technique, the scored variables have been logrank tested for a prognostic trend. In 155 patients, p for symptom-free survival between subgroups with low and high scores was 0.0019 and for relative survival 0.0005. This implies that a combination of variables may have predictive value in bladder cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256802
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Bladder carcinoma treated by preoperative radiotherapy followed by cystectomy (1978)
    Springer
    Urological research 6 (1978), S. 253-254 
    Details
    ISSN: 1434-0879
    Keywords: Preoperative irradiation ; Cystectomy ; Bladder carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 1969 a clinical trial was started where patients with bladder carcinoma stage T2 and grade 3 were subjected to preoperative radiotherapy followed by cystectomy. The survival rate in this series was higher than in a previous series of comparable patients who were given full irradiation without cystectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262629
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Orgotein (superoxide dismutase): A drug for the amelioration of radiation-induced side effects (1978)
    Springer
    Urological research 6 (1978), S. 255-257 
    Details
    ISSN: 1434-0879
    Keywords: Orgotein ; Superoxide dismutase ; Radiation side effects ; Bladder tumour ; Cystitis ; Proctitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Orgotein, the drug version of Cu-Zn superoxide dismutases is a new and safe anti-inflammatory agent. Animal experiments have shown that it does not interfere with the tumourolytic effects of radiation or chemotherapy. A double-blind, placebo-controlled study has demonstrated that orgotein injected after each daily irradiation session can be used safely and effectively to ameliorate or prevent the side effects due to high-energy radiation therapy (8,400 or 6,400 rads) of bladder tumours. Orgotein significantly reduced the signs and symptoms both in the bladder and the bowel, indicating that it provides a therapeutic regimen for control of these side effects, which to date could only be treated symptomatically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262630
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Chemotherapy in bladder carcinoma (1978)
    Springer
    Urological research 6 (1978), S. 263-264 
    Details
    ISSN: 1434-0879
    Keywords: Bladder carcinoma ; Chemotherapy ; Carcinoma in situ ; Papillomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a series of patients with recurrent bladder carcinoma, treatemnt with various cytostatic drugs was generally unsatisfactory in cases of infiltrating carcinoma. Better results were achieved using instillation of Thiotepa for bladder papillomatosis and by instillation of Adriamycin for carcinoma in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262632
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    Paper (German National Licenses)
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