ISSN:
1432-1912
Keywords:
Carmine
;
Lithium
;
Embryotoxic Actions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Carmine in a 1% lithium carbonate solution, forms the acid vital dye lithium carmine. The present paper deals with the question whether the embryotoxic and teratogenic effects resulting from the administration of lithium carmine to mice are due to the carmine itself or to the lithium ions. Mice of the NMRI/Han strain were injected i. p. on the 8th day of pregnancy with 100 mg/kg carmine using either a 2.5% or a 4.0% lithium carmine solution. A third group of mice received 40 mg/kg lithium carbonate in 1% solution, corresponding to the dose of lithium given by injecting the 2.5% solution of lithium carmine. Control animals were injected with 0.2 ml of saline. The following results were obtained: 1. A dose of 100 mg/kg carmine, injected as a 2.5 or a 4.0% of lithium carmine solution, is embryotoxic and teratogenic. With both solutions the number of resorbed, malformed and retarded fetuses is nearly the same. 2. Injection of lithium carbonate significantly raises the number of resorptions, but only 1 out of 79 fetuses was malformed. The rate of retardations does not exceed that of the controls. 3. The malformations, which are described in some detail, are localized in the brain (exencephalies) and skeletal system (malformations of ribs and vertebral column).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997299
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