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  • Carnitine  (2)
  • Hydrocephalus  (2)
  • Sarcoplasmic reticulum  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A spectrophotometric method for the determination of free and esterified carnitine
    Amsterdam : Elsevier
    Clinica Chimica Acta 182 (1989), S. 87-93 
    Details
    ISSN: 0009-8981
    Keywords: Carnitine ; Serum ; Spectrophotometric assay ; Urine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(89)90152-6
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The corpus callosum in communicating and noncommunicating hydrocephalus (1995)
    Springer
    Neuroradiology 37 (1995), S. 212-218 
    Details
    ISSN: 1432-1920
    Keywords: Key words Corpus callosum ; Hydrocephalus ; Dementia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate morphological changes in the corpus callosum in hydrocephalus and to correlate them with clinical findings we studied sagittal T2*-weighted cine MR images of 163 patients with hydrocephalus. The height, length and cross-sectional area of the corpus callosum were measured and related to the type of cerebrospinal fluid flow anomaly and to clinical features, especially dementia. With expansion of the lateral ventricles the corpus callosum showed mainly elevation of its body and, to a lesser degree, increase in length. Upward bowing was more pronounced in noncommunicating than in communicating hydrocephalus. Dorsal impingement on the corpus callosum by the free edge of the falx correlated with the height of the corpus callosum. Cross-sectional area did not correlate with either height, length or impingement; it was, however, the strongest anatomical discriminator between demented and nondemented patients. The area of the corpus callosum was significantly smaller in patients with white matter disease. Our findings suggest that, due to its plasticity, the corpus callosum can to some degree resist distortion in hydrocephalus. Dementia, although statistically related to atrophy of the corpus callosum, is possibly more directly related to white matter disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578260
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The corpus callosum in communicating and noncommunicating hydrocephalus (1995)
    Springer
    Neuroradiology 37 (1995), S. 212-218 
    Details
    ISSN: 1432-1920
    Keywords: Corpus callosum ; Hydrocephalus ; Dementia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate morphological changes in the corpus callosum in hydrocephalus and to correlate them with clinical findings we studied sagittal T2*-weighted cine MR images of 163 patients with hydrocephalus. The height, length and cross-sectional area of the corpus callosum were measured and related to the type of cerebrospinal fluid flow anomaly and to clinical features, especially dementia. With expansion of the lateral ventricles the corpus callosum showed mainly elevation of its body and, to a lesser degree, increase in length. Upward bowing was more pronounced in noncommunicating than in communicating hydrocephalus. Dorsal impingement on the corpus callosum by the free edge of the falx correlated with the height of the corpus callosum. Cross-sectional area did not correlate with either height, length or impingement; it was, however, the strongest anatomical discriminator between demented and nondemented patients. The area of the corpus callosum was significantly smaller in patients with white matter disease. Our findings suggest that, due to its plasticity, the corpus callosum can to some degree resist distortion in hydrocephalus. Dementia, although statistically related to atrophy of the corpus callosum, is possibly more directly related to white matter disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578260
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Exercise-induced fibre type transitions with regard to myosin, parvalbumin, and sarcoplasmic reticulum in muscles of the rat (1984)
    Springer
    Pflügers Archiv 400 (1984), S. 432-438 
    Details
    ISSN: 1432-2013
    Keywords: Exercise ; Muscle fibre types ; Myofibrillar actomyosin ATPase ; Myosin light chains ; Parvalbumins ; Sarcoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of a long-term, high intensity training program upon histochemically assessed myofibrillar actomyosin ATPase, myosin composition, peptide pattern of sarcoplasmic reticulum (SR), and parvalbumin content were analysed in muscles from the same rats which were used in a previous study (Green et al. 1983). Following 15 weeks of extreme training, an increase in type I and type IIA fibres and a decrease in type IIB fibres occurred both in plantaris and extensor digitorum longus (EDL) muscles. In the deep portion of vastus lateralis (VLD), there was a pronounced increase from 10±5% to 27±11% in type I fibres. No type I fibres were detected in the superficial portion of vastus lateralis (VLS) both in control and trained animals. An increase in slow type myosin light chains accompanied the histochemically observed fibre type transition in VLD. Changes in the peptide pattern of SR occurred both in VLS and VLD and suggested a complete transition from type IIB to IIA in VLS and from type IIA to I in VLD. A complete type IIA to I transition in the VLD was also suggested by the failure to detect parvalbumin in this muscle after 15 weeks of training. Changes in parvalbumin content and SR tended to precede the transitions in the myosin light chains. Obviously, high intensity endurance training is capable of transforming specific characteristics of muscle fibres beyond the commonly observed changes in the enzyme activity pattern of energy metabolism. The time courses of the various changes which are similar to those in chronic nerve stimulation experiments, indicate that various functional systems of the muscle fibre do not change simultaneously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587545
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Subnormal carnitine levels and their correction in artificially fed patients from a neurological intensive care unit: a pilot study (1990)
    Springer
    Journal of neurology 237 (1990), S. 213-215 
    Details
    ISSN: 1432-1459
    Keywords: Carnitine ; Tube feeding ; Serum levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primary and secondary carnitine deficiency syndromes are characterized by myopathy, encephalopathy and hepatopathy. We measured plasma levels of free and esterified carnitine in 20 patients from our neurological intensive care unit who required intravenous or tube feeding. After 2–3 weeks 19 patients showed a 30%–60% decrease in the levels of serum free and total carnitine. As soon as oral feeding was recommenced, carnitine levels quickly returned to normal. These data suggest the need for new carnitine-enriched feeding fluids, which are presently under investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314597
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Immunochemical quantification of sarcoplasmic reticulum Ca2+-ATPase and calsequestrin in muscle biopsies from patients with myotonia congenita and paramyotonia congenita Eulenburg (1994)
    Springer
    Journal of neural transmission 95 (1994), S. 29-38 
    Details
    ISSN: 1435-1463
    Keywords: Sarcoplasmic reticulum ; Ca2+-ATPase ; calsequestrin ; myotonia congenita ; paramyotonia congenita Eulenburg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A sensitive enzyme-linked immunoadsorbant assay was developed to quantify Ca2+ -ATPase and calsequestrin from sarcoplasmic reticulum in human muscle biopsies. Tissue levels of Ca2+ -ATPase and calsequestrin averaged 51.5 ± 28.1 and 6.4 ± 1.8mg/g muscle protein, respectively, in control muscles (means ± SD, n=12). The high sensitivity and specificity of the antibodies make the assay a useful tool in the diagnosis of human neuromuscular disorders where defects in sarcoplasmic reticulum function may be expected. The assay was applied to muscle biopsies from patients with myotonia congenita and paramyotonia congenita Eulenburg. The calsequestrin concentration was normal in all patient muscles. The Ca2+ -ATPase content was also within the normal range but varied considerably with the percentage distribution of slowtwitch fibres. This indicates that the prolonged relaxation observed in the muscles of patients with these disorders is not caused by faulty expression of Ca2+-ATPase and calsequestrin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01283028
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    Paper (German National Licenses)
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