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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of postural ataxia after intake of alcohol (1983)
    Springer
    International journal of legal medicine 90 (1983), S. 159-165 
    Details
    ISSN: 1437-1596
    Keywords: Alcohol, effect on the spinocerebellum ; Posturography ; Alkohol, Wirkung auf Spinocerebellum ; Posturographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Alkoholwirkung auf die Standsicherheit wurde in einem Akutexperiment bei 12 gesunden Versuchspersonen untersucht. Sie tranken innerhalb 1h 11 Wein. Die danach gemessenen Blutalkoholspiegel lagen zwischen 0,9 und 1,67 mg/ml. Die Standmessung am Ende der Trinkphase und 1h danach ergab bei geschlossenen Augen eine signifikante Zunahme der Körperunruhe, vor allem durch vermehrtes antero-posteriores Schwanken. Der Vergleich der Ergebnisse der Posturographie im Akut-experiment und bei Patienten mit umschriebenen cerebellären Läsionen verschiedener Lokalisation zeigt, daß auch im Akutexperiment, wie durch den chronischen Abusus, vor allem das Spinocerebellum durch den Alkohol in seiner Funktion beeinträchtigt wird.
    Notes: Summary The effect of an acute intoxication with alcohol on the stability of stance was examined in 12 healthy subjects. They drank 11 of wine within 1h. The resulting blood alcohol concentrations ranged between 0.9 and 1.67 mg/ml. Static posturography at the end of drinking and 1h later revealed a significant increase in body sway which was mainly due to an increase in anteroposterior sway only present with closed eyes. A comparison of the results of posturography after acute intoxication with the data of patients with permanent lesions confined to the different functional subunits of the cerebellum shows that the acute effect of alcohol largely resembles that of a chronic lesion of the cerebellar anterior lobe (the spinocerebellum).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116226
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of ataxia in alcoholic cerebellar atrophy through alcohol abstinence (1984)
    Springer
    Journal of neurology 231 (1984), S. 258-262 
    Details
    ISSN: 1432-1459
    Keywords: Alcoholic atrophy ; Alcohol abstinence ; Posturography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Postural instability was measured and short, medium and long latency EMG responses to angular displacement of the ankle were recorded from leg muscles in a group of 17 alcoholics who presented with clinical signs of cerebellar atrophy of the anterior lobe. Recordings were performed twice (average interval 18.5 months) to determine the effects of continued drinking versus abstinence on the signs of the cerebellar damage. Patients who were abstinent (n=11) exhibited a significant, sometimes dramatic decrease of body sway whereas patients who continued drinking (n=6) showed increased body sway when the eyes were closed. Short and medium latency EMG responses were unaltered in both groups of patients. The integral of the long latency response of the antagonist tended to increase with continued abuse and to decrease in abstinent patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313662
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  • 3
    Electronic Resource
    Electronic Resource
    Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics (1986)
    Springer
    Journal of neurology 233 (1986), S. 212-217 
    Details
    ISSN: 1432-1459
    Keywords: Alcoholic neuropathy ; Alcoholic cerebellar degeneration ; Posturography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 78 chronic alcoholics were examined neurologically as well as by electroneurography, myography and posturography. Clinical signs of peripheral neuropathy were detected in 45% of these patients, with electromyographic and neurographic abnormality in 67% and 55% respectively. Clinical signs of cerebellar ataxia were found in 33% of our patients, whereas posturographic measurements of increased sway were recorded in 69%. The posturographic characteristics of cerebellar anterior lobe atrophy were observed in two-thirds of the latter patients. The severity of cerebellar-ataxia did not correlate with the degree of neuropathy. This lack of correlation is interpreted as an indication of different pathogenetic mechanisms acting on peripheral nerves and cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314021
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebellar dysfunction in patients with bronchogenic carcinoma: clinical and posturographic findings (1988)
    Springer
    Journal of neurology 235 (1988), S. 290-296 
    Details
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314176
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  • 5
    Electronic Resource
    Electronic Resource
    Ocular key symptoms of extracranial cerebrovascular disease (1981)
    Springer
    European archives of psychiatry and clinical neuroscience 230 (1981), S. 129-139 
    Details
    ISSN: 1433-8491
    Keywords: Carotid stenosis ; Ocular symptoms ; Ischemic ophthalmopathy ; Ischemic optic neuropathy ; Retinal embolism ; Carotisstenose ; Augensymptome ; Ischämische Ophthalmopathie ; Opticusneuropathie ; Retinale Embolien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 46 Patienten mit einer durch direkte Dopplersonographie gesicherten Stenose oder einem Verschluß der A. carotis interna erfolgte eine ophthalmologische Untersuchung. Neun Patienten wiesen dabei eine ischämische Ophthalmopathie auf. Acht litten unter Amaurosis fugax, sechs unter einer ischämischen Opticusneuropathie, fünf unter retinaler Embolie und drei unter Gesichtsfelddefekten. Zwei der obengenannten Patienten hatten zwei verschiedene oculäre Manifestationen. Sieben Patienten waren ophthalmologisch unauffällig. Zehn Patienten wiesen Erkrankungen der Augen auf, die nicht offensichtlich in Beziehung zu dem Verschlußprozeß der extrakraniellen Arterien standen. Eine ischämische Ophthalmopathie, gemäß augenärztlicher Primärdiagnose, war immer die Folge einer hochgradigen Stenose oder eines Verschlusses der A. carotis interna.
    Notes: Summary Forty-six patients with stenosis or occlusion of the internal carotid artery were evaluated by direct Doppler sonography and ophthalmologic examination. A retrospective analysis showed the following secondary ocular manifestations of vascular disease: ischemic ophthalmopathy (9), amaurosis fugax (8), ischemic optic neuropathy (6), and retinal embolism ((5). Two patients had two ocular manifestations; three showed homonymous visual field defects. Results of the ophthalmologic examination were normal in seven patients. Eye changes not obviously related to extracranial vascular disease were present in ten patients. Ischemic ophthalmopathy was invariably due to an occlusive disease of the internal carotid artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345173
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  • 6
    Electronic Resource
    Electronic Resource
    Neuropsychological changes associated with stenoses or occlusions of the carotid arteries (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 69-73 
    Details
    ISSN: 1433-8491
    Keywords: Extracranial vascular disease ; Neuropsychological deficit ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 33 Patienten mit hämodynamisch relevanten Carotisstenosen oder -verschlüssen psychodiagnostisch untersucht. 22 litten an transitorisch ischdmischen Attacken, 6 hatten einen leichten Schlaganfall erlitten, 5 waren asymptomatisch. Patienten mit hämodynamisch relevanten Carotisstenosen Im Vergleich mit der altersentsprechenden Normalpopulation waren die intellektuellen Funktionen intakt; es bestanden aber deutliche Einschränkungen im mnestischen Bereich, in der Aufmerksamkeit und im Bereich psychomotorischer Reaktionen. Für die Ausprägung der neuropsychologischen Ausfälle war es irrelevant, ob uni- oder bilatere Stenosen im Carotiskreislauf vorlagen. Die Untersuchung zeigt, daß auch bei asymptomatischen Patienten und solchen mit reversiblen neurologischen Ausfdllen bereits manifeste neuropsychische Störungen bestehen können.
    Notes: Summary A total of 33 patients with a relevant stenosis or occlusion of extracranial arteries were tested for a number of neuropsychological functions. Most of them [22] suffered from transient ischemic attacks, 6 from strokes, 5 were asymptomatic. Compared to an age-matched population of normals, patients showed an impairment in their mnemic functions, and attention under stress as well as in their psychomotor function. The degree of neuropsychological impairment was independent of the unilaterality or bilaterality of carotid stenoses. The results illustrate the neuropsychological deficit even in asymptomatic patients and those with complete recovery from transient neurological deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432886
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  • 7
    Electronic Resource
    Electronic Resource
    Neuropsychological functions after carotid endarterectomy (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 74-77 
    Details
    ISSN: 1433-8491
    Keywords: Carotid endarterectomy ; Neuropsychological changes ; Endarterektomie ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir führten bei 23 Patienten mit uni- oder bilateralen hämodynamisch relevanten Carotisstenosen vor und zehn Monate nach einer Endarterektomie testpsychologische Untersuchungen durch. Präoperativ hatten die meisten Patienten TIA (15), fünf hatten einen leichten Schlaganfall erlitten, drei waren asymptomatisch. Die Nachuntersuchung zeigte leicht verbesserte intellektuelle Funktionen, während die mnestischen Funktionen eher schlechter waren als vor der Operation. Die psychomotorischen Funktionen zeigten — ebenso wie die persönlichkeitsbezogenen Tests — keine wesentlichen Unterschiede. Die prophylaktische Wirkung der Endarterektomie zur Vorbeugung von Schlaganfällen ist unumstritten; eine wesentliche Verbesserung der neuropsychologischen Veränderung ist aber in der Regel nicht zu erwarten
    Notes: Summary Psychological testing was performed on 23 patients (mean age 60.7 years) with unilateral or bilateral stenoses of the carotid arteries prior to and 10 months after carotid endarterectomy. Intellectual functions were slightly improved, mnemic functions impaired, psychomotor functions and dimension of personality remained unchanged. Carotid endarterectomy, although improving neuropsychological functions in a few cases, on average does not cause a significant improvement. This underscores the preventive character of the surgical intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432887
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