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  • 1
    Electronic Resource
    Electronic Resource
    The murine Bis1 seizure gene and the Kcnab2 gene encoding the β2-subunit of the K+ channel are different (2000)
    Springer
    Neurogenetics 2 (2000), S. 231-234 
    Details
    ISSN: 1364-6753
    Keywords: Key words Kcnab2 ; Bis1 ; K+ channel ; Epilepsy ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT¶We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the β2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice (1995)
    Springer
    Psychopharmacology 117 (1995), S. 67-73 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine dihydro-β-erythroidine ; Antinociception ; Calcium ; Mecamylamine ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The comparative in vivo pharmacology of mecamylamine and dihydro-β-erythroidine (DHβE) in mice was studied. Modulation of the behavioral effects (antinociception, hypomotility, motor impairment and hypothermia) of nicotine in mice by DHβE and mecamylamine were carried out. After SC administration, DHβE and mecamylamine were nearly equipotent in blocking nicotine's effects except for antinociception, in which mecamylamine was clearly more potent. Intrathecal injection of DHβE was also effective in blocking the antinociceptive effect of nicotine. In vivo interaction of DHβE with calcium and calcium channels, involved in the central actions of nicotine, showed that intrathecal administration of DHβE failed to reduce the antinociception induced by diverse drugs which increase intracellular calcium such as thapsigargin, (±)-BAYK 8644 and calcium, indicating that this antagonist does not affect calcium-dependent mechanisms involved in antinociception. On the other hand, mecamylamine blocked the antinociceptive effect of the calcium modulatory drugs, suggesting that it may be acting on calcium-dependent mechanisms involved in the intracellular signaling process. We conclude that DHβE, a nicotinic neuromuscular antagonist, is able to block some of the central actions of nicotine after systemic and intrathecal administration. The mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of DHβE on nicotine receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245100
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Is the dopaminergic system involved in the central effects of nicotine in mice? (1993)
    Springer
    Psychopharmacology 111 (1993), S. 106-108 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ; Dopamine antagonists ; Hypoactivity ; Hyperactivity ; Antinociception ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with ineffective doses of the D1 antagonist SCH23390 but not the D2 antagonist sulpiride reduced hyperactivity induced by nicotine in mice habituated to the test cage. On the other hand, the D1 and D2 antagonists were ineffective in blocking nicotine-induced hypoactivity in naive mice. Finally, SCH23390 and sulpiride did not block the antinociception induced by nicotine. Our data indicate that the dopamine receptors D1 and D2 are not involved in all the central effects of nicotine in mice, but seems to be a substrate for locomotor activation induced by nicotine under specific experimental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257415
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of the nerves innervating the muscle of the body of the bladder (1975)
    Springer
    Cell & tissue research 164 (1975), S. 133-144 
    Details
    ISSN: 1432-0878
    Keywords: Bladder body ; Mammals ; Musculature ; Innervation ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the nerves supplying the muscle of the body of the bladder in mammals such as the mouse, guinea-pig, rabbit, cat and dog was compared with that previously demonstrated in the rat. The muscle of the arterioles located between the muscle bundles is innervated by a fine perivascular plexus and the nerves forming the muscular plexus can be divided into inter-and intra-fascicular components. Terminals containing variable but usually small numbers of clear and large dense-cored vesicles are particularly numerous in the interfascicular nerves and the intrafascicular nerves are characterised by large numbers of terminals with the features of those of cholinergic axons. In addition to many small clear vesicles, the cholinergic terminals contained some small dense-cored vesicles, and it is suggested that, as in the rat, these contain a second transmitter which is released with acetylcholine at the terminals during impulse transmission. Adrenergic terminals are more common in the muscular plexuses of the guinea-pig, dog and cat than in those of the other animals studied and there is evidence for the presence of two types of such terminal in the nerves. Of these, one contains a much smaller proportion of small vesicles with dense cores and many more large dense-cored vesicles than the second, and the possibility of a relationship between such terminals and those of short adrenergic neurones and neurones associated with non-adrenergic patterns of impulse transmission is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221700
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of ureteric innervation (1975)
    Springer
    Cell & tissue research 160 (1975), S. 515-524 
    Details
    ISSN: 1432-0878
    Keywords: Ureteric innervation ; Mammals ; Interspecies differences ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the ureteric nerves in a small series of mammals was compared with that previously demonstrated in the rat. There was marked interspecies variation in the extent to which the nerves penetrated the wall of the ureter and in the degree of development of the deep submucous plexus. In animals with a highly developed deep submucous plexus, terminal arterioles frequently passed through the muscle coat before breaking up into capillaries. These vessels were surrounded by a fine periarteriolar plexus and were accompanied in their course through the muscle coat by one or more branches of the adventitial nerves. Intramuscular nerves not related to arterioles contained few axons with terminals classifiable as either adrenergic or cholinergic, and in animals in which the muscle cells were arranged in fascicles rather than in sheets, the nerves were typically interfascicular in position. As in the rat, only the periarteriolar plexuses contained large numbers of adrenergic axons. Cholinergic axons were generally few, but were not uncommon in the deep submucous plexus when this was well-developed. The majority of the terminals encountered in the intramural nerves contained variable and usually small numbers of both clear and large dense-cored vesicles. The relationship between these terminals and those defined in the submucous nerves of the rat ureter was discussed and it was suggested that the marked variations in the diameter of the axons in the terminal areas and in the number of vesicles in the terminals were related to the effects of the mechanical and other derangements which occur during processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225768
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