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  • 1
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; Catecholamines ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study of 31 patients with suspected pheochromocytoma we examined the preoperative results of131I-metaiodobenzylguanidine (131-I-MIBG) scintigraphy and a fluorimetric urine catecholamine determination test. An additional radioenzymatic plasma catecholamine determination test was performed in 25 patients. In 14 of the 31 patients the diagnosis of pheochromocytoma was later histologically confirmed. In the remaining 17 patients the suspected diagnosis was finally rejected after a clinical decision had been made on the basis of clinical history, symptoms, laboratory and imaging tests. 131-I-MIBG scintigraphy apparently had a very high specificity (no false-positive results among the patients with rejected diagnosis), but showed the least sensitivity (3 of 14 tumours were not detected). Urine cate-cholamines showed two false-negative and three false-positive results. Plasma catecholamines had the highest sensitivity and gave only one false-positive result. Because of its high pathognomonic value 131-MIBG scintigraphy can be helpful not only for localization, but also for confirmation of diagnosis when catecholamine determination tests are contradictory. On the basis of our experience with false-positive results after interfering medication therapy, urine and plasma catecholamine determination tests should only be carried out after purification with thin layer chromatography or high performance liquid chromatography.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 764-767 
    ISSN: 1432-1440
    Keywords: Catecholamines ; Clonidine ; Pheochromocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we examined the preoperative value of the clonidine-suppression test in 15 patients with surgically proved pheochromocytomas. The result of the clonidine-suppression test was pathological (epinephrine plus norepinephrine above 500 ng/l 3 h after clonidine) in 10 of 15 patients (66%). These patients had relatively large tumors and higher basal norepinephrine plasma levels. Out of the 5 cases without a pathological clonidine test 4 had normal basal plasma catecholamine levels with the result that the clonidine test could not be properly applied and 1 case produced a false negative result. These 5 cases generally had smaller tumors and lower plasma catecholamine levels. Two of these cases had basally raised epinephrine values. The other three cases had either a paradoxical increase or a suspiciously low fall (less than 25%) in norepinephrine within the normal range. We conclude that the clonidine-suppression test is only reliable for the diagnosis of relatively large pheochromocytomas.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 25 (1996), S. 486-500 
    ISSN: 0887-3585
    Keywords: protein-DNA interaction ; DNA bending ; helix-turn-helix ; Poisson-Boltzmann electrostatics ; docking ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A method is presented to predict overall conformations of protein-DNA complexes on the basis of the known three-dimensional structures of the proteins. The method is restricted to proteins with a common twofold symmetry axis, which show only minor conformational changes upon binding to DNA. The method uses a numerical finite difference solution of the linearized Poisson-Boltzmann equation and subsequent energy minimization cycles. Structural parameters - the rotation angle of the DNA relative to the protein around the common symmetry axis, the protein-DNA distance, and intermolecular hydrogen-bonding contacts - are presented for two test cases, DNA bound to CAP (catabolite gene activator protein) and to the Cro-repressor of bacteriophage 434. The DNA curvature in the starting model of the docking procedure was chosen as a smoothed approximation of the conformation found in the X-ray structures of these complexes. The method is further used to predict the unknown structure of the complex between the factor for inversion stimulation (FIS) and DNA, which is bent upon binding to FIS. In contrast to the test cases, the unknown curvature of the starting model is derived from a calibration of electrostatic precalculations for different proteins according to crystallographically observed DNA bending. The results of the modeling are in good accordance with the experimentally observed overall structure of protein-DNA complexes for the two test cases; for FIS, they correspond to several of the experimentally proposed protein-DNA contacts. © 1996 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 30 (1987), S. 514-520 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model describing the affinity partitioning of macromolecules in aqueous two-phase systems has been derived. The model was used to calculate binding parameters that were compared against values deter mined by means of ultracentrifugation and fluorescence titration. The mathematical model and its modifications were found to describe satisfactorily the partition behavior of macromolecules with differing numbers of binding sites. It could be shown that in solutions containing PEG the binding behavior of FDH is changed fundamentally. The dissociation constants of FDH with PEG-blue in the presence and absence of PEG are different.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 214 (1933), S. 33-43 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung von reinem Schwefelmonoxyd bei höheren Drucken wird beschrieben und seine stöchiometrische Zusammensetzung durch Elementaranalyse der Formel SO entsprechend ermittelt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 299 (1959), S. 87-91 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The vapour pressures of a number of metal complex compounds with aromatic ligands were determined in the range of 10-2 to 1 mm Hg by the effusion method of Knudsen. The application of a vacuum thermo balance was favorable.
    Notes: Die Dampfdrucke einiger Aromatenkomplexe wurden für Drucke um und unter 1 Torr nach der Knudsenschen Effusionsmethode gemessen. Besonders vorteilhaft erwies sich bei diesen Untersuchungen der Gebrauch einer Vakuumthermowaage.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 380 (1971), S. 231-240 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Newly calculated values of the dipol polarizabilities of singly charged metal ions are used in the calculation of the dissociation energy D0 and of the anharmonicity constant ωexe of group IIa, IIIa, IVa and Ib monohalides. Comparison with experimental values from literature suggests the empirical model as reasonable approximation.
    Notes: Neu berechnete Werte der Dipol-Polarisierbarkeiten der einfach geladenen Metallionen werden zur Berechnung der Dissoziationsenergie D0 und der Anharmonizitätskonstanten ωexe von Monohalogeniden der Elemente der Gruppen Ha. IIa, IVa und Ib mit einem elektrostatischen Moleküloodell benutzt. Der Vergleich mit experimentellen Werten aus der Literatur zeigt, daß das Modell als empirisches Verfahren trotz großer Vereinfachungen gute Werte liefert.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 279 (1955), S. 94-103 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Umsetzung zwischen MgCl2 und CaC2 verläuft im pulverförmigen Gemisch mit merkbarer Geschwindigkeit erst bei Temperaturen oberhalb der Soliduslinie des Systems CaCl2—MgCl2 (Eutektikale bei 622° C).  -  In Gegenwart von NaCl (ternäres Eutektikum bei 425° C) beginnt die Umsetzung bereits bei 500°. Primär entsteht MgC2, das oberhalb 550° in Mg2C3 umgesetzt wird. Die thermische Beständigkeitsgrenze von Mg2C3 (Zerfall in die Elemente) wird bei 740-750° gefunden.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 306 (1960), S. 121-132 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The diffusion in the system Sn - Pb has been measured at various concentrations and temperatures. It can be shown that the diffusion coefficient increases with the concentration of tin and reaches a maximum at the phase boundary. The dependance of the concentration can be described by a quadratic equation. In the heterogenous area, the diffusion  -  which is supposed to be a lattice diffusion  -  mainly proceeds through primary α- or β-crystals, depending on their amounts. A small part of the metal atoms migrate through the eutectic, low diffusion coefficients and activation energy pointing at a diffusion through grain boundaries.
    Notes: In der vorliegenden Arbeit wird die Konzentrations- und Temperaturabhängigkeit der Diffusion im Legierungssystem Zinn-Blei untersucht. Es wird gezeigt, daß der Diffusionskoeffizient im α-Mischkristallgebiet mit der Zinn-Konzentration ansteigt und an der Phasengrenze ein Maximum erreicht. Die Konzentrationsabhängigkeit läßt sich in Form einer quadratischen Gleichung darstellen. Im heterogenen Legierungsgebiet erfolgt die Diffusion vorwiegend über α- bzw. β-primär-Kristalle, sie ist von deren Anzahl abhängig und wird als Gitterdiffusion angenommen; ein geringer Anteil der Metallatome wandert über das vorliegende Eutektikum, niedrige Diffusionskoeffizienten und geringe Aktivierungsenergie deuten bier auf eine Korngrenzendiffusion.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 337 (1965), S. 1-5 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: In the alloy system Sn—Sb, the relationships between concentration and the partial and self diffusion coefficients were calculated from measurements.It is shown that even the self diffusion besides the partial diffusion is dependent on concentration, contrary to the system Ag—Al.
    Notes: Im Legierungssystem Sn—Pb werden im α-Mischkristall die Konzentrationsabhängigkeit der partiellen und der Selbst-Diffusionskoeffizienten (DK) aus vorliegenden Messungen berechnet. Es kann gezeigt werden, daß nicht nur die partiellen DK, sondern auch die Koeffizienten der Selbstdiffusion im Gegensatz zum Legierungssystem Ag—Al konzentrationsabhängig sind.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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