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  • Chemistry  (4)
  • Cell & Developmental Biology  (3)
  • Neoplasms  (3)
  • 1
    ISSN: 1432-1084
    Keywords: MR ; Perfusion study ; Brain ; Necrosis ; Edema ; Neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to characterize intracranial tumors based on MR measurements of regional cerebral blood volume. In 8 patients without intracranial pathology and 42 patients with intracranial tumors a T2*-weighted image series was acquired during bolus injection of gadolinium-DTPA, and regional cerebral blood volume maps were calculated. The regional cerebral blood volume index (rCBVi) of vital tumor was expressed in percent of the value measured in contralateral gray matter. In extra-axial tumors (meningiomas) rCBVi was higher (124 ± 110%), and in low-grade intra axial tumors rCBVi was lower (79 ± 65%), than in contralateral cortex. In malignant intra-axial tumors the distribution of rCBV was heterogenous: high in vital tumor (glioblastomas: rCBVi = 165 ± 85%; metastases: rCBVi = 106 ± 79%), but low in necrosis (rCBVi = 33% of contralateral white matter) and edema (rCBVi = 53% of contralateral white matter). rCBVi was highest in arteriovenous malformations (1053 ± 584% of contralateral gray matter). We conclude that the regional cerebral blood volume distribution is useful to characterize intracranial tumors, although the large biological variability of individual tumor entities indicates limitations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 9 (1999), S. 428-435 
    ISSN: 1432-1084
    Keywords: Key words: Liver ; Neoplasms ; Ultrasound ; Doppler studies ; Contrast media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Echo patterns of focal liver lesions as well as other morphological criteria do not suffice for differential diagnosis. In an attempt to increase the specificity of ultrasound of focal liver lesions, several years of Doppler-flow information was evaluated. Recent advances in ultrasound technology (power Doppler imaging, second harmonic imaging) as well as commercial availability of an intravenous signal enhancer (contrast agent) have additionally improved results of this technique.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1084
    Keywords: Key words: MR ; Surface coils ; Pulse sequences ; Eye ; Neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To develop an improved investigation protocol for MRI studies of intraocular lesions, imaging with a small surface coil (diameter 6 cm) was compared with a standard surface coil (diameter 11 cm). Both coils were assessed initially on an eye phantom and then by studying 22 patients with uveal melanoma and similar lesions of the eye. The influence of bandwidth and field or view (FOV) were systematically studied and evaluated quantitatively. A smaller bandwidth improved image quality independent of surface coil size. The subsequent secondary increase in chemical shift artefact was acceptable. Smaller FOVs (60–80 mm) necessitated the use of a smaller surface coil. A smaller bandwidth also proved to be advantageous with the use of the smaller surface coil. In conclusion, a smaller-diameter surface coil improves MR imaging of ocular lesions. Pulse sequences with a small bandwidth maintain an acceptable signal-to-noise ratio when the FOV is reduced.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A brief introduction describes the main differences between homo, and copolymer polyacetals and their main degradation mechanisms. A short overview describes the importance of stabilization and the necessity of using antioxidants and costabilizers during manufacturing, processing and end use of polyoxymethylene(polyacetals). Various stabilizer systems are presented and studies on the interaction of antioxidants with costabilizers added. The criteria for testing the performance of these additives are discussed and demonstrated by many examples.In a second part the increasing importance of light stabilized polyacetal is mentioned and investigations on the performance of light stabilizer systems are highlighted.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: After a few general remarks with regard to degradation of polyurethanes under the influence of light, some new results considering the stabilization of such systems will be treated. Apart from a comparison between aromatic and aliphatic one component systems for textile coating, the main subject of this paper is the light stabilization of integral-PUR foams as well as the stabilization of thermoplastic polyurethane. New fully liquid systems as light stabilizers for PUR may be of special interest.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 70 (1998), S. 596-603 
    ISSN: 0730-2312
    Keywords: poly(ADP-ribose) ; PARP ; nuclear matrix ; noncovalent interactions ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Recent evidence suggests that poly(ADP-ribose) may take part in DNA strand break signalling due to its ability to interact with and affect the function of specific target proteins. Using a poly(ADP-ribose) blot assay, we have found that several nuclear matrix proteins from human and murine cells bind ADP-ribose polymers with high affinity. The binding was observed regardless of the procedure used to isolate nuclear matrices, and it proved resistant to high salt concentrations. In murine lymphoma LY-cell cultures, the spontaneous appearance of radiosensitive LY-S sublines was associated with a loss of poly(ADP-ribose)-binding of several nuclear matrix proteins. Because of the importance of the nuclear matrix in DNA processing reactions, the targeting of matrix proteins could be an important aspect of DNA damage signalling via the poly ADP-ribosylation system. J. Cell. Biochem. 70:596-603. © 1998 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1988), S. 399-404 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A gas chromatographic/mass spectrometric procedure has been developed for the quantification in plasma of dideoxycytidine (DDC), a candidate anti-AIDS drug. The assay uses an extraction with ethyl acetate containing 10% methanol followed by three derivatization steps: (i) reaction with t-butyl dimethyl chlorosilane to silylate the 5′-hydroxyl group; (ii) pentafluorobenzoylation of the amino group with pentafluorobenzoyl chloride; (iii) methylation of the ring nitrogen adjacent to the amino group with diazomethane. The resulting derivative is quantified using stable isotope dilution, selective ion monitoring and methane negative chemical ionization mass spectrometry. Plasma concentrations of DDC were measured over a range of 2-200 ng ml-1 using 1 ml plasma for extraction.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 33 (1926), S. 121-135 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 26 (1923), S. 121-128 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The stabilization of polyamides or nylons, considered the oldest engineering plastics, has been the subject of many patents in the last 50 years. Most of these patents refer to attempts to improve the resistance of polyamides against the negative influence of heat and oxygen. Light stability, however, was always of certain interest as well, and more so in recent years when polyamide producers started to search seriously for new fields of application.Some general remarks will be made on how to test the heat stability of this substrate group. The three different types of heat stabilizing systems with their advantages and disadvantages will be discussed briefly. Among these three systems - copper halides, secondary aromatic amines and phenolic antioxidants - the latter will be dealt with in some depth.Some information will cover investigations on stabilization of polyamides in general. Another study will be presented that deals with the behavior of polyamide 6 at various elevated temperatures. The results of an extraction of polyamide 66 with boiling water will be explained including discussion of the consequences.An example will also be given for the heat stabilization of polyamide 12.Some general remarks on testing polyamides under the influence of light lead to several considerations concerning light stabilizer systems for polyamides. Examples will be given for polyamides 6, 66 and 12.A short survey of the status quo with regard to polyamide stabilization and an outlook for the future will conclude this paper.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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