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  • 11
    Electronic Resource
    Electronic Resource
    Mikrobiologische Umwandlungen nichtsteroider Strukturen. IX Mikrobiologische Hydroxylierung von Δ8-Tetrahydrocannabinol (1976)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 109 (1976), S. 3606-3614 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Microbiological Transformations of Nonsteroidal Structures, IX Microbiological Hydroxylation of Δ8TetrahydrocannabinolΔ8Tetrahydrocannabinol (5) is hydroxylated at the ring system and the side chain by fermentations with Pellicularia flilamentosa or Streptomyces lavendulae. P. filamentosa yields the compounds 7β,3′- (1) und 7β,4′-dihydroxy-Δ8-tetrahydrocannabinol (3) as well as 8β,9α-dihydroxy-(2a) und 8β,9α,4′-trihydroxy-6a,10a-trans-hexahydrocannabinol (4a), whereas S. lavendulae leads to 7α-hydroxy- (6), 7α,2′- (7), 7α,3′- (8), 7α4′-Dihydroxy-Δ8-tetrahydrocannabinol (9) und 4′-hydroxy-7-oxo-Δ8-tetrahydrocannabinol (10).
    Notes: Δ8Tetrahydrocannabinol (5) wird durch Fermentationen mit Pellicularia filamentosa oder Streptomyces lavendulae gleichzeitig am Ringsystem und in der Seitenkette hydroxyliert. P. filamentosa ergibt die Produkte 7β,3′- (1) und 7β,4′-Dihydroxy-Δ8-tetrahydrocannabinol (3) sowie 8β,9α-Dihydroxy-(2a) und 8β,9α,4′-Trihydroxy-6A,10a-trans-hexahydrocannabinol (4a), während S. lavendulae zu 7α-Hydroxy-(6), 7α,2′- (7), 7α,3′- (8), 7α4′-Dihydroxy-Δ8-tetrahydrocannabinol (9) und 4′-Hydroxy-7-oxo-Δ8-tetrahydrocannabinol (10) führt.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19761091114
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  • 12
    Electronic Resource
    Electronic Resource
    Mikrobiologische Umwandlung von Steroiden, XV: Mikrobiologische Hydroxylierung von 3α-Acetoxy-5β-pregnan-20-carbonsäure und deren Methylester mit Calonectria decora und Syncephalastrum racemosum (1978)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 2143-2151 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Microbial Transformations of Steroids, XV: Microbial Hydroxylation of 3α-Acetoxy-5β-pregnane-20-carboxylic Acid and of its Methyl Ester by Calonectria decora and Syncephalastrum racemosum3α-Acetoxy-5β-pregnane-20-carboxylic Acid (1) is hydroxylated by fermentation with Calonectria decora in 12β- (3), 7β,11β- (4), and 1β,12β-position (5) with hydrolysis of the 3-acetoxy group. The methyl ester 2 is attacked in 7α,12β- (6), 7β, 11α- (7), and 12β,15α-position (8), Syncephalastrum racemosum forms from 1 the hydroxy products in positions 11β (9), 12β (3), 7β,11β (4), and 11β,15β (10) as well as the further transformation products 3α-hydroxy- (13), 3α,11β-dihydroxy- (14), 3α,12β-dihydroxy-5β,20α-pregnane-20,18-carbolactone (11), and 11,18-epoxy-3α-hydroxy-5β,20α-pregnane-20,18-carbolactone (16), 1 is transformed by Mycobacterium smegmatis into methyl 3-oxo-pregnane- (18) and 3-oxo-1,4-pregnadiene-20-carboxylate (20).
    Notes: 3α-Acetoxy-5β-pregnan-20-carbonsäure (1) wird durch Fermentation mit Calonectria decora unter Verseifung der 3-Acetylgruppe in 12β- (3), 7β,11β- (4) und 1β,12β-Stellung (5) hydroxyliert. Der Methylester 2 wird analog in 7α,12β- (6), 7β,11α- (7) und 12β, 15α-Position (8) angegriffen. Syncephalastrum racemosum bildet aus 1 die Hydroxylierungsprodukte in den Positionen 11β (9), 12β (3), 7β,11β (4) und 11β,15β (10) sowie die weiteren Umwandlungsprodukte 3α-Hydroxy- (13), 3α,11β-Dihydroxy- (14), 3α,12β-Dihydroxy-5β,20α-pregnan-20,18-carbolacton (11) sowie 11,18-Expoxy-3α-hydroxy-5β,20α-pregnan-20,18-carbolacton (16). Durch Mycobacterium smegmatis wird 1 zu 3-Oxo-4-pregnen- (18) und 3-Oxo-1,4-pregnadien-20-carbonsäure-methylester (20) umgewandelt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19781110611
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  • 13
    Electronic Resource
    Electronic Resource
    Über Sublimationsversuche mit Kohlenhydraten (1922)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 5 (1922), S. 575-576 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19220050419
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  • 14
    Electronic Resource
    Electronic Resource
    Recherches sur les silicates (1928)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 11 (1928), S. 731-750 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: L'étude de la conductibilité des silicates aux températures élevées peut servir à déceler et à suivre des réactions dont ces silicates peuvent être le siège.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19280110185
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  • 15
    Electronic Resource
    Electronic Resource
    Eine einfache Methode zur Gewinnung gesättigter tertiärer Carbonsäuren (1935)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 18 (1935), S. 721-724 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19350180198
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  • 16
    Electronic Resource
    Electronic Resource
    Sexualhormone XIII. Bereitung des 17-Äthyl-testosterons und der 3-trans, 17-cis-Diole des Androstans und Androstens. Weitere Beiträge zur Spezifität der Sexualhormone (1936)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 19 (1936), S. 357-366 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19360190156
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  • 17
    Electronic Resource
    Electronic Resource
    Sexualhormone X. Herstellung des 17-Methyl-testosterons und anderer Androsten- und Androstanderivate. Zusammenhänge zwischen chemischer Konstitution und männlicher Hormonwirkung (1935)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 18 (1935), S. 1487-1498 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.193501801203
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  • 18
    Electronic Resource
    Electronic Resource
    Mikrobiologische Umwandlungen nichtsteroider Strukturen, III.I. und II. Mitteil.: H. Kosmol, K. Kieslich und H. Gihian, Liebigs Ann. Chem. 711, 38 bzw. 42 (1968). Hydroxylierung von 5-Alkyl-2-(benzolsulfonylamino)pyrimidinen und strukturverwandten Antidiabetika (1973)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 106 (1973), S. 1290-1302 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Microbiological Transformations of Nonsteroidal Structures, III. Hydroxylation of 5-Alkyl-2-(benzenesulfonylamino)pyrimidines and Structurally Related Antidiabetics5-Alkyl-2-(arylsulfonylamino)pyrimidines (1-5 and 11-16) have been hydroxylated microbiologically Propyl, butyl, and isobutyl groups were hydroxylated at C-2, ethyl groups at C-1, isopropyl groups at C-1 and C-2, and neopentyl groups at C-3, respectively, by Streptomyces griseolus. The sulfonylurea part of the antidiabetics glibenclamid (25) and glisoxepid (29) was degradated to sulfonamide; in addition, hydroxyl groups were introduced into the 2- and 4-positions of the cyclohexane ring of 25.
    Notes: 5-Alkyl-2-(arylsulfonylamino)pyrimidine (1-5 und 11-16) wurden mikrobiologisch hydroxyliert. Mit Streptomyces griseolus wurden Propyl-, Butyl- und lsobutylgruppen an C-2, äthylgruppen an C-1, Isopropylgruppen an C-1 und C-2, sowie Neopentylgruppen an C-3 hydroxyliert. Die Antidiabetika Glibenclamid (25) und Glisoxepid (29) mit Sulfonylharnstoff-Struktur wurden zu Sulfonamiden abgebaut, ferner wurden in 2- und 4-Stellung des Cyclohexanrings von 25 Hydroxylgruppen eingeführt.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19731060426
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  • 19
    Electronic Resource
    Electronic Resource
    Functional anatomy of pulmonary ventilation in the garter snake, Thamnophis elegansPortions of this paper were presented at the June, 1972 meeting of the Amer. Soc. of Ichthyologists and Herpetologists. (1973)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 140 (1973), S. 171-184 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The functional anatomy of pulmonary ventilation in Thamnophis elegans was studied by electromyography. Flow of air into and out of the lungs follows a triphasic pattern and occurs while the glottis is held open by a dilator muscle. Non-ventilatory rest periods characterized by a closed glottis and lack of ventilatory movements occur between breaths. Exhalation is caused by contraction of a pair of dorsolateral sheets of muscle that extends from the ventral surface of the vertebral column to the medial surfaces of the ribs and a pair of ventro-lateral sheets that extends from the medial surfaces of the ribs to the mid-ventral skin. Inspiration is powered by contraction of a series of rib levators and retractors. The last phase of the ventilatory cycle is a passive expiration that may be caused by elastic recoil of the walls of the filled lungs and relaxation of muscles used during inspiration. The site of respiratory pumping is shifted craniad after large prey items have been completely ingested. The significance of this shift and its anatomical basis are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051400205
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  • 20
    Electronic Resource
    Electronic Resource
    Development of the subdigital adhesive pads of Ptyodactylus guttatus (Reptilia: Gekkonidae) (1992)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 211 (1992), S. 243-258 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Subdigital adhesive pads play an important role in the locomotion of many species of gekkonid lizards. These pads consist of integrated components derived from the epidermis, dermis, vascular system, subcuticular tendons, and phalanges. These components become intimately associated with each other during the developmental differentiation of the digits and the sequence of this integration is outlined herein in Ptyodactylus guttatus. The pads initially appear as paired swellings at the distal tips of the digits. Subsequently, a fan-like array of naked scansors develops on the ventral surface of each digit, at about the same time that scales differentiate over the surface of the foot as a whole. At the time of appearance of the naked scansors, the vascular sinus system of the pad also differentiates, along with subcuticular connective tissue specializations. At this stage the digits, along with the rest of the body, are clad in an embryonic periderm. Only after hatching and as the periderm is shed, do the epidermal setae and spines appear. The developmental sequence described here is consistent with predictions previously advanced about the evolutionary origin and elaboration of subdigital pads in gekkonid lizards. The paucity of available staged embryonic material leaves many questions unresolved.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1052110302
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