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  • 1
    Electronic Resource
    Electronic Resource
    A Golgi study of the opossum ventral basal complex (1983)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 177 (1983), S. 277-299 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The morphology of neurons in the ventral basal complex (VBC) of the adult opossum (Didelphis virginiana) is described from thick coronal brain sections, using Golgi-, horseradish peroxidase (HRP)-, and Nissl-staining methods. Soma cross-sectional area, dendritic field shape, and the number of appendages (spines) in a defined major branch zone (MBZ) are quantified and statistically analyzed. Results indicate that neurons in opossum VBC have relatively large cell bodies, dendrites which branch in a tufted pattern, and numerous dendritic appendages. These neurons are designated as relay cells because of (1) their tufted dendritic branch patterns, considered characteristic of thalamic relay cells (Ramon-Moliner, '62), and (2) the similarity of their soma sizes with HRP-labeled somata after somatosensory cortical injections. Neurons with traditionally described interneuron morphology do not appear to be present in the VBC of this animal, and, in this respect, the neuronal morphology of opossum VBC is similar to that in rat (McAllister and Wells, '81).Based on statistical analysis of the structural features observed, the presumed relay cells in opossum VBC do not show significant differences in morphology, and consequently are not subdivided into classes. Opossum VBC neurons are recognized as forming a single category in which broad and continuous variations in morphology are indicated. Recognition of a singular class of relay cell is consistent with descriptions for rat and cat VBC (Scheibel and Scheibel, '66), but at variance with a previous report for the primate Galago VBC (Pearson and Haines, '80) subdividing thalamic relay cells into Types I, II, and intermediate categories.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051770306
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  • 2
    Electronic Resource
    Electronic Resource
    Stability of fiber spinning of power-law fluids (1972)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 12 (1972), S. 219-223 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A stability analysis of fiber spinning of isothermal power-law fluids has been carried out. The analysis for purely viscous fluids indicates that the critical extension ratio increases with an increase in power-law constant q above 1. For q greater than approximately 1.5, very high values of critical extension ratio are obtained. A stability analysis in the presence of viscous and inertial forces indicates that for q 〉 1 critical extension ratio can be correlated to a quantity Rq = q - 1 + 3Re, wherein Re is the Reynolds number. For the values of Rq greather than approximately 0.5, very high values of critical extension ratios are obtained.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760120311
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  • 3
    Electronic Resource
    Electronic Resource
    Polymer flows dominated by high heat generation and low heat transfer (1978)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 18 (1978), S. 222-229 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This paper aims to review recent studies of the flow of non Newtonian (temperature and shear rate dependent) viscous fluids and to relate them to commonly encountered difficulties in polymer processing. The flows considered take place in narrow channels or pipes, and are dominated by viscous forces. Heat generation and temperature variations are taken to be the most significant aspects. A dimensionless formulation of the energy and stress equations is employed, thus bringing out the role of Graetz, Nahme-Griffith and Brinkman numbers. These latter are introduced as ratios of temperature differences. Special consideration is given to the question of the stability of such flows.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760180309
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  • 4
    Electronic Resource
    Electronic Resource
    Biodegradation of and tissue reaction to poly(DL-lactide) microcapsules (1986)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 667-676 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820200510
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of particle size on the in vitro and in vivo degradation rates of poly(DL-lactide-co-glycolide) microcapsules (1988)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 22 (1988), S. 733-746 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Three different sieve size fractions of ergotcontaining biodegradable microcapsules were examined both in vitro and in vivo. The sieve sizes and average particle diameter, (μm), were: less than 45-75 (X̄ = 30); 75-106 (X̄ = 79), 106-177 (X̄ = 130). These microcapsules contained ca. 9% drug and were produced from 50:50 poly(DL-lactide-co-glycolide). The objective was to determine the effect of particle size on in vivo and in vitro degradation rates. The microcapsules were injected into rat gastrocnemius muscle and excised and examined at various time points up to 70 days. Initially a minimal tissue response was noted which was characterized by a sharply localized acute inflammatory reaction. Following this, connective tissue and foreign body giant cells engulfed the microcapsules at 20-30 days. Only vestiges of the microcapsules were found surrounded by minimal connective tissue and foreign body giant cells after 60-70 days. The tissue reaction was a minimal, sharply localized foreign body giant cell and connective tissue process for all three size groups of microcapsules. The largest microcapsules (X̄ = 130 μm) exhibited a slightly greater tendency to undergo in vivo and in vitro degradation relative to the other groups. However, it can be concluded that over the microcapsule size ranges examined minimal differences in the degradation properties of the polymeric matrices and consequently those of the microcapsules were noted.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820220806
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  • 6
    Electronic Resource
    Electronic Resource
    Biodegradation of and tissue reaction to 50:50 poly(DL-lactide-co-glycolide) microcapsules (1985)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 19 (1985), S. 349-365 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The biodegradation of the copolymer 50:50 poly(DL-lactide-CO-glycolide)-lypressin microcapsules was studied by light and electron microscopic methods and 14C release. Intramuscular injection sites of microcapsules in rats were studied by dissecting and conventional light microscopy as well as scanning (SEM) and transmission electron microscopy. A minimal localized acute myositis was seen initially at the injection sites. By Day 4, a few small foreign body giant cells were present participating in the minimal foreign body response. Later the inflammatory cells decreased and the individual microcapsules were walled off by immature fibrous connective tissue and large syncytial foreign body giant cells. By Day 35, definitive changes in some microcapsules, consisting of a granular and slightly eroded appearance of the internal matrix, were seen by SEM. By Day 42, the outer rims of the microcapsules were extensively eroded. At Day 56, the inflammatory and connective tissue reactions were almost completely resolved and biodegradation continued so that only remnant pieces of the microcapsules were present at Day 63. The morphologic picture correlated well with loss of 14C radioactivity, which could no longer be detected at the injection sites on Day 56. Phagocytosis did not seem to be an important factor in the biodegradation.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820190315
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  • 7
    Electronic Resource
    Electronic Resource
    Permeability of human venous endothelial cell monolayers perfused in microcarrier cultures: Effects of flow rate, thrombin, and cytochalasin D (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 149 (1991), S. 88-99 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have applied a multiple isotope dilution technique to examine junctional permeability of human umbilical vein endothelial cells (HUVEC) in vitro. Primary cultures were grown to confluence on porous Cytodex-3 microcarrier beads, packed into 0.3 ml columns (3 × 106 cells) and perfused at varying flow rates (0.3-1.2 ml/min) with HEPES-buffered Tyrodes solution containing unlabeled cyanocobalamin, insulin, and albumin. Columns were challenged periodically with mixtures of radioactive tracers of different molecular size. Permeability to 22Na+, [57Co]cyanocobalamin (1.3 kD), [125l]insulin (6 kD) or [125l]albumin (66 kD) was assessed relative to [131l]lgG (160 kD, impermeant reference tracer) by comparing column elution profiles. Although the single passage extraction of [125l]albumin by beads alone approximated 40%, the presence of confluent HUVEC rendered these beads effectively impermeable to albumin. High junctional extractions were measured for cyanocobalamin (0.79 ± 0.02, n = 28) and insulin (0.51 ± 0.05, n = 14) in cultures perfused at 0.3-0.4 ml/min, and tracer extraction decreased as perfusion rates increased. Permeability coefficients for cyanocobalamin (9.66 × 10-5 cm/s) and insulin (4.18 × 10-5 cm/s) increased significantly during perfusion with thrombin (10 U/ml) or cytochalasin D (1 μg/ml), whereas permeability to albumin (0.39 × 10-5 cm/s) remained unchanges. Morphological studies, using the glycocalyx stain ruthenium red, revealed that thrombin or cytochalasin D increased the penetration of the stain into junctions between endothelial cells.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041490112
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  • 8
    Electronic Resource
    Electronic Resource
    Studies of cage reactions III. A test over a wide temperature range (1969)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 1 (1969), S. 357-359 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550010308
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