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  • Cell & Developmental Biology  (1)
  • Chemotherapy  (1)
  • N-butyl-N-(4-hydroxybuty)nitrosamine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats (1987)
    Springer
    Urological research 15 (1987), S. 329-334 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Chemotherapy ; Rat urinary bladder tumor ; N-butyl-N-(4-hydroxybutyl) nitrosamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divided into 26 groups to follow regimens of single chemotherapy. All drugs were administered intraperitoneally except in one group that was treated orally. In our experimental series, 5-fluorouracil (5-FU), N-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), carbazilquinone (CQ), vincristine (VCR) and cis-diamminedichloroplatinum (CDDP) were effective in inhibiting the incidence of bladder tumor, however, adriamycin (ADM), mitomycin C (MMC), neocarsinostatin (NCS), cyclophosphamide (CPM) and bleomycin (BLM) were not effective.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00265661
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  • 2
    Digitale Medien
    Digitale Medien
    Rat urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine and N-methyl-N-nitrosourea (1990)
    Springer
    Urological research 18 (1990), S. 323-326 
    Details
    ISSN: 1434-0879
    Schlagwort(e): N-butyl-N-(4-hydroxybuty)nitrosamine ; N-Methyl-N-nitrosourea ; Rat bladder carcinogenesis ; Papillary carcinoma ; Non-papillary carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present investigation was conducted to examine the combination effect of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) and N-methyl-N-nitrosourea(MNU) in rat urinary bladder carcinogenesis. Experiment 1 was performed in the groups treated by oral BBN administration in combination with MNU intraversical instillation and their control groups. In the groups given both BBN and MNU, the ratio of rats with the nonpapillary type to carcinoma-bearing rats was significantly higher than in the controls. Since most of the carcinomas were non-invasive, the observation period was prolonged in the groups given both BBN and MNU in experiment 2. However, even after a longer observation period, no invasive carcinoma was observed. These results suggest that high-grade and invasive carcinomas similar to those induced by BBN and MNU in the heterotopically transplanted rat bladder cannot be induced in the natural bladder of the rat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00300780
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of various enzymes on the ability of hamster egg plasma membranes to fuse with spermatozoa (1978)
    New York, NY : Wiley-Blackwell
    Gamete Research 1 (1978), S. 3-12 
    Details
    ISSN: 0148-7280
    Schlagwort(e): Fusion ; Spermatozoa ; Eggs ; Golden hamster ; plasma membrane ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie
    Notizen: To investigate which component of the plasma membrane of the hamster egg plays the central role in the sperm-egg fusion, the egg membrane was treated with a variety of proteolytic, carbohydrate-hydrolyzing, lipid-hydrolyzing, and other enzymes. The only enzyme that markedly effected the ability of the egg membrane to fuse with spermatozoa was phospholipase C. The lipid moieties of the egg plasma membrane (and possibly of the sperm membrane) must be of primary importance in sperm-egg fusion at fertilization.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrd.1120010103
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