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  • Plasma catecholamines  (7)
  • Cell & Developmental Biology  (5)
  • DNA repair  (4)
  • 1
    ISSN: 0378-1119
    Keywords: Ataxia-telangiectasia ; Cockayne's syndrome ; DNA repair ; genomic DNA ; recombinant DNA ; transfection ; xeroderma pigmentosum
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research DNA Repair Reports 194 (1988), S. 57-63 
    ISSN: 0167-8817
    Keywords: Chloramphenicl acetyltransferase ; DNA repair ; Host-cell reactivation ; Human cells
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0167-8817
    Keywords: DNA repair ; Gene transfer ; Molecular aspects ; Molecular cloning ; Workshop
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 865-871 
    ISSN: 1432-1440
    Keywords: Plasma catecholamines ; Beta-receptors ; Training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 6 sports students (VO2 max. 54.0±2.6 ml/kg·min) and 6 marathoners (VO2 max. 65.7±2.0 ml/kg·min) performed graded treadmill tests. Free plasma catecholamines (noradrenaline and adrenaline), heart rate, lactate were assessed at rest and during exercise. The behaviour of beta-adrenergic receptors of polymorphonuclear leukocytes was estimated additionally before the treadmill test. The maximum running velocity was 14.6±0.8 km/h (sports students) and 17.3±0.6 km/h (marathoners). Noradrenaline was approximately 46% (v=12 km/h) to 67% (v=14 km/h) lower in the group of marathoners than in sports students; adrenaline showed no or smaller differences between both grops. No significant differences in the plasma catecholamine behaviour occurred between the groups at rest and during maximum exercise. Specific binding of3H-Dihydroalprenolol to intact cells was higher in the marthoners than in sports students (p〈0.01). Scatchard analysis revealed a maximum binding of 21.1 fmol/107 cells (sports students) and 35.3 fmol/107 cells (marathoners), which indicated approximately 1,300 (sports students) and 2,150 binding sites/cell (marathoners). Inverse correlations between noradrenaline (r=−0.63), VO2max. (r=−0.79) and the specific binding of3H-DHA were observed. The reduction of plasma catecholamines (approximately 46–67%) and the increase in specific binding sites (approximately 67%) were in the same range. These training dependent changes may be indicative for an economical adaptation process.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 403-408 
    ISSN: 1432-1440
    Keywords: Plasma catecholamines ; Hemodynamic values ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma noradrenaline, adrenaline, central hemodynamic values (Swan-Ganz flow directed catheter), and peripheral arterial pressure were measured in 12 control subjects (NOR) and 12 patients with essential hypertension (HYP) at rest and during graduated bicycle ergometric exercise. Anthropometric data, relative heart volume, performance, and cardiac output showed no significant differences between NOR and HYP. Pulm. capill. wedge pressure (PCPm) — as a reference value of enddiastolic left ventricular pressure — showed a tendency to higher values in HYP; peripheral syst., diast. arterial pressure, circ. resistance, and heart rate (during heavy exercise) were significant higher in HYP and the stroke volume lower than in NOR. At rest, plasma catecholamines were slightly higher in HYP than in NOR (p〈0.05); during exercise, they were significantly elevated (p〈0.01-0.001) compared with NOR. At rest in all subjects, noradrenaline showed correlations with circ. resistance (r=0.56,p〈0.01), and cardiac output (r=−0.45,p〈0.05); during exercise (at the 100 watt level), correlations occured between PCPm (r=0.51,p〈0.05), syst. (r=0.50,p〈0.05), diast. pressure (r=0.79,p〈0.001), circ. resistance (r=0.59,p〈0.01), cardiac output (r=−0.49,p〈0.05), and noradrenaline. Adrenaline showed a similar tendency. A correlation between noradrenaline and diast. pressure was also observed in the group of HYP during exercise (r=0.56,p〈0.05). The correlations are not indicative for a causal relationship between increased catecholamines and the pathogenesis of hypertension. The increased catecholamines of the HYP may be induced by the elevated circ. resistance and the beginning of left ventricular dysfunction.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 50 (1982), S. 261-271 
    ISSN: 1432-1246
    Keywords: Graduated, continuously increasing exercise ; Plasma catecholamines ; Stufenweise, kontinuierlich zunehmende Ergometerarbeit ; Plasmacatecholamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Adrenalin, Noradrenalin, Lactat, Glucose, Glycerin und die freien Fettsäuren im Blut Bowie die Herzfrequenz und Sauerstoffaufnahme wurden bei sechs gesunden männlichen Personen (28 ± 6 Jahre) während einer stufenweisen (I) und annähernd kontinuierlich (II) zunehmenden Fahrradergometrie im Sitzen bestimmt. Die maximale Herzfrequenz, die VO2 max, die maximale Lactatkonzentration und der maximale Fettsäurespiegel unterscheiden sich nicht, Adrenalin, Noradrenalin und der Glucosespiegel sind während der maximalen Ergometerarbeit bei II signifikant niedriger als bei I, der Glycerinspiegel tendenziell hoher. Auf vergleichbaren submaximalen Stufen sind Lactat und die Herzfrequenz tendenziell, Adrenalin und Noradrenalin auf mehreren Stufen bei II signifikant niedriger als bei I, die freien Fettsäuren, Glycerin und die Sauerstoffaufnahme zeigen keine signifikanten Unterschiede. Die Arbeitszeit ist bei beiden Untersuchungen vergleichbar lang, die Gesamtarbeit ist während II ca. 50% geringer, die maximale Leistung tendenziell II W im Mittel höher als bei I. Die erhobenen Befunde können Bedeutung für die Arbeitsplanung im Berufsleben, die Bewegungstherapie von Patienten und für die Trainingsgestaltung von Sportlern haben.
    Notes: Summary Adrenaline, noradrenaline, glucose, glycerol and the free fatty acids (FFA) in the blood, as well as the heart rate and oxygen intake, were tested in six healthy male volunteers (age: 28 ± 6 years) during graduated (I) and continuously (II) increasing bicycle ergometric exercise (upright body position). The maximum heart rate, the VO2 max, the maximum lactate and FFA concentration show no significant difference, whereas adrenaline, noradrenaline and the glucose levels are significantly lower, and the glycerol concentration is slightly higher during the maximum test II as compared with test I. At some submaximum exercise levels, the lactate concentration and the heart rate are slightly lower, adrenaline and noradrenaline are significantly lower during test II; the FFA, glycerol and the oxygen intake do not show any significant difference. The duration of exercise was similiar in both tests. The total work was about 50% lower in test II, and the maximum performance was slightly higher as compared with test I. These results could have significance for the planning of working conditions, the rehabilitation of patients, and the organisation of training for athletes.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 52 (1983), S. 301-314 
    ISSN: 1432-1246
    Keywords: Plasma catecholamines ; Exercise ; Plasmakatecholamine ; Körperarbeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Neun Probanden absolvierten 2 unterschiedliche, stufenweise Fahrrad-Ergometerbelastungen im Sitzen. Test 1 begann mit 50 Watt und wurde nach 3 min um 50 Watt als Modell einermetabolisch-kardialen Ausbelastung gesteigert. Test 2 begann mit 100 Watt and wurde nach je 15 min um 50 Watt als Modell einerperipher-muskulären Ausbelastung gesteigert. Ermittelt wurden Plasmakatecholamine, Laktat- und Glukosespiegel, Herzfrequenz und O2-Aufnahme. Folgende Resultate (Mittelwerte) wurden bei Ausbelastung beobachtet. Belastung 305 (Test 1) and 233 Watt (Test 2), Arbeitszeit 17,5 min (1) and 51 min (2), Herzfrequenz 185 min−1 (1) and 175 min−1 (2), Noradrenalin 30,7 (1) and 11,0 (2), Adrenalin 6,9 (1) and 2,0 nmol · l−1 (2), Laktat 9,2 (1) and 6,6 (2), Glukose 5,6 (1) and 4,7 mmol · 1−1 (2). Hochintensive dynamische Körperarbeit (Test 1) geht mit mehrfach höherer Plasmakatecholaminkonzentration und Laktatazidose (Arbeitsazidose) einher als ausdauernde, peripher-muskulär limitierte Körperarbeit (Test 2); dies läßt einen erhöhten kardiovaskulären and metabolischen Stress erwarten. Oberhalb 30% VO2 max ist mit Nor- and Adrenalinanstieg zu rechnen; unterhalb 50–70% VO2 max wird Steady-state-Verhalten, darüber Unsteady-state-Verhalten beobachtet. Dopamin zeigt keine deutliche Zeit- and Belastungsabhängigkeit während Körperarbeit. Nor- and Adrenalin folgen derselben initialen Plasmaeliminationskinetik 1. Ordnung (e −0,048).
    Notes: Summary Nine healthy subjects performed 2 different graded bicycle ergometric tests. The 1st test started with 50 watt and was increased 50 watt after 3 min till exhaustion as a model of a metabolic and cardiac exhaustion. The 2nd test started with 100 watt and was increased 50 watt after 15 min till exhaustion as a model of a peripheral-muscular exhaustion. The behaviour of plasma catecholamines, lactate and glucose levels, heart rate and oxygen intake was examined. The results were as following: Performance ability 305 (test 1) and 233 watt (test 2; mean values), work time 17.5 min (1) and 51 min (2), heart rate 185 min−1 (1) and 175 min−1 (2), noradrenaline 30.7 nmol/l (1) and 11.0 nmol/1 (2), adrenaline 6.9 nmol/l (1) and 2 nmol/1(2), lactate 9.2 (1) and 6.6 mmol/l (2), glucose 5.6 mmol/l (1) and 4.7 mmol/l (2). During highly intensive dynamic exercise (test 1), three times higher catecholamine and 50% higher lactate responses were observed, than during peripheral-muscular limited endurance exercise (test 2). Above an exercise level of more than 30% VO2 max., nor- and adrenaline increased significantly. Below 50–70% VO2 max. steady-state-behaviour occurred. Above this range unsteadystate-behaviour of plasma catecholamines was observed. Dopamine did not show any significant time and intensity dependent increase. Noradrenaline and adrenaline followed the same initial 1st order elimination kinetic.
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  • 8
    ISSN: 1432-1440
    Keywords: Graduated exercise ; Plasma catecholamines ; Metabolic substrates ; Stufenweise Ergometerarbeit ; Plasmacatecholamine ; Metabolische Substrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß einer stufenweise zunehmenden Fahrradergometrie im Liegen und Sitzen auf die Belastbarkeit, die Plasmacatecholamine, den Kohlehydrat- (Glucose, Lactat) und Fettstoffwechsel (Freie Fettsäuren, Glycerin), sowie die Herzfrequenz und Sauerstoffaufnahme wurde bei sechs gesunden Probanden (28,0±2,6 Jahre) untersucht. Die Leistungsfähigkeit ist im Sitzen ca. 30% höher. Adrenalin und Noradrenalin sind auf allensubmaximalen Stufen und beimaximaler Ergometerarbeit im Liegen niedriger. Glucose, freie Fettsäuren und Glycerol zeigen auf gleichensubmaximalen Stufen keine signifikanten Unterschiede in Abhängigkeit von der Ergometrieform, der Lactatspiegel ist jedoch im Liegen bei 200 Watt ca. 30% höher. Währendmaximaler Ergometerarbeit im Sitzen ist der Glucosespiegel ca. 10% höher als im Liegen, die Freien Fettsäuren zeigen keinen Unterschied; die Lactatkonzentration ist ca. 37%, der Glycerinspiegel ca. 40% höher als im Liegen; die metabolischen Veränderungen während maximaler Ergometerarbeit im Sitzen sind in erster Linie Folge der höheren Wattleistung. Die Herzfrequenz und die Sauerstoffaufnahme zeigen auf submaximalen Stufen keine von der Ergometrieform abhängigen signifikanten Unterschiede, wenngleich sie im Liegen stets etwas niedriger sind. Sie sind während maximaler Ergometerarbeit im Sitzen, bedingt durch die höhere Belastungsintensität 15% (Herzfrequenz) und ca. 30% (Sauerstoffaufnahme) höher als im Liegen.
    Notes: Summary The influence of a graduated bicycle ergometric test in supine and sitting position on the work capacity, the plasma catecholamines, the carbohydrate (glucose and lactate) and lipid metabolism (free fatty acids and glycerol) and the heart rate and oxygen intake was examined in six healthy subjects. The work capacity is approx. 30% higher in sitting position. In supine position, adrenaline and nor-adrenaline are lower at rest, at all submaximum levels and during maximum ergometric exercise. Glucose, free fatty acids and glycerol show no differences dependent on the body position at the same submaximum levels, only the lactate level is approx. 30% higher (200 Watt) in supine position. During maximum graduated exercise in sitting position the glucose level is 10% higher than in supine position, the free fatty acids show no difference; the lactate level is approx. 37% higher, the glycerol level approx. 40% than in supine position. The heart rate and the oxygen intake don't show any position dependent differences at rest and at the same submaximum levels. During maximum ergometric exercise they are 15% (heart rate) and about 30% (oxygen intake) higher than in supine position, corresponding to a higher exercise level.
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  • 9
    ISSN: 1432-1440
    Keywords: Bicycle exercise ; Treadmill exercise ; Plasma catecholamines ; Energy metabolism ; Aercbic / anaerobic capacity ; Fahrradergometrie ; Laufbandergometrie ; Plasmacatecholamine ; Energiestoffwechsel ; aerob-anaerobe Kapazität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 6 gesunden männlichen Probanden (28,0±2,6 Jahre) wurden Adrenalin, Noradrenalin, Glucose, Lactat, Freie Fettsäuren und Glycerin im Blut, sowie die Herzfrequenz und Sauerstoffaufnahme vor, während und nach einer stufenweise ansteigenden Laufbandergometrie (LBE) und Fahrradergometrie (FE) bestimmt. Adrenalin, Noradrenalin, die energiereichen Substrate und die Sauerstoffaufnahme unterscheiden sich während der LBE und FE auf submaximalen Stufen nicht, bei maximaler FE ist Noradrenalin 27% (0,10〉p〉0,05 höher, die Herzfrequenz ist 6% (p〈0,05), die Sauerstoffaufnahme 4% (p〉0,05), der Glycerinspiegel 25% (0,10〉p〉0,05) niedriger. Die Tendenz zur höheren Noradrenalinfreisetzung während der FE kann durch die größere statisch-pressorische Beanspruchung gegenüber einer dynamisch zirkulatorischen während der LBE bedingt sein. Die verstärkte Alpha-Rezeptoren-Stimulation führt zu einem negativ chronotropen Effekt, als dessen Ursache eine Barorezeptorenerregung anzunehmen ist. Die LBE bedingt eine höhere Zirkulation und eine günstigere Sauerstoffversorgung der Arbeitsmuskulatur und bevorzugte Fettoxidation, kenntlich am schnelleren Anstieg des Glycerinspiegels (0,10〉p〉0,05). Beide Ergometrieformen sind bezüglich der Arbeitsazidose — wenn auch bei der LBE die Tendenz zu einer geringeren Lactatproduction auf submaximalen Stufen besteht —, der Sauerstoffaufnahmefähigkeit, der energieliefernden Substrate und des Catecholaminverhaltens miteinander vergleichbar; eine Verfälschung tritt nur ein, wenn die Plasmacatecholamine und der Lactatspiegel auf die Herzfrequenz bezogen werden, da diese von der Art der Belastungsform mitbestimmt wird.
    Notes: Summary Adrenaline, noradrenaline, glucose, lactate, free fatty acids, and glycerine in blood, as well as heart frequency and oxygen intake were examined in 6 healthy male subjects (28±2.6 years) before, during and after a graduated treadmill (TME) and bicycle ergometer (BE) test. Adrenaline, noradrenaline, the energy supplying substrates, and the oxygen-intake show no differences during TME and BE at given submaximal levels. Noradrenaline is 27% (0.10〈p〈0.05) higher, pulse rate is 6% (p〈0.05) lower, oxygen intake 4% (〉0.05) lower, and the glycerine level 25% (0.10〈p〈0.05) lower during maximal BE exercise. The tendency toward a higher noradrenaline release during BE exercise can be influenced by a greater static-pressuric stress opposed to a dynamic-circulatory stress during TME testing. An increased alphareceptor stimulation leads to a negative chronotropic effect, whose cause is assumed to be a baroreceptor stimulation. The TME induces a higher circulation and a more economic oxygen supplying of the muscles exercised, as well as a favourable fat oxidation, which is recognizable by a more rapid increase of glycerine (0.10〈p〈0.05). When referring to exercise acidification (a tendency toward a lower lactate production during submaximal TME testing shows here), oxygen intake capability, energy supplying substrates, and the catecholamines, both forms of ergometer testing are comparable one to another; a falsification appears only when plasma catecholamines and lactate levels are based on the heart frequency, as it is influenced by the form of exercise.
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  • 10
    ISSN: 1439-6327
    Keywords: Heart rate deflection ; Lactate performance curve ; Plasma catecholamines ; Cycle ergometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The correlation between the behaviour of the heart rate/work performance (f c W) curve and blood lactate ([la]b) and plasma adrenaline/noradrenaline concentrations ([A]/[NA]) during incremental cycle ergometer exercise was investigated. A group of 21 male sports students was divided into two groups: group I, with a clear deflection of thef c W curve; group II, without or with an inverse deflection of thef c W curve. The aerobic threshold (Thaer) and the lactate turn point (LTP) were defined. Between Thaer and maximal work performance (f c W max) the behaviour of thef c W curve as well as the behaviour of [la−]b and [A]. [NA] were described mathematically. Thef c, systolic blood pressure (BPS),W, [la−]b, [A] and [NA] at rest, Thaer, LTP,f c W max, after 3 and 6 min of recovery (Re3/Re6) were calculated. A significant difference between the two groups could only be detected forf c at LTP, Re3 and Re6 (P 〈 0.05). No significant, correlation could be found between individualf c W-behaviour and individual time course of [la−]b, [A] and [NA]. However, a significant correlation was visible between [la−/W-behaviour and individual catecholamine response. These results and the fact that the different flattening at the top of thef c W curve was related to diminished stress-dependent myocardial function led us to the conclusion that it is possible that sympathetic drive is not directly involved in mechanisms of regulation between load dependentf c and myocardial function. In addition, individualf c W behaviour was independent of BPS andW max, or individual conditions of energy supply.
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