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  • Cell Cultures  (1)
  • immunodeficiency  (1)
  • monoclonal antibodies  (1)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 48 (1992), S. 63-67 
    ISSN: 1420-9071
    Keywords: SCID mice ; Pneumocystis carinii ; immunodeficiency ; pneumonia ; monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract clinically healthy SCID mice were infected intratracheally withPneumocystis carinii (PC) of human origin. The data obtained provides unambiguous evidence that progressive multiplication of PC organisms of human origin takes place in the lungs of experimentally infected animals. SCID mice that were infected with human-derived PC also revealed a markedly greater number of mouse PC organisms in their lungs than the controls. All the SCID recipients of human PC died by day 65 post infection, whereas the controls, housed under identical conditions, started dying significantly later due to severe mouse pneumocystosis. This animal model could be used for the maintenance and propagation of human PC, and for evaluating strategies for treating human pneumocystosis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 226-233 
    ISSN: 1432-1440
    Keywords: Mycoplasma ; Cell Cultures ; Mycoplasma ; Zellkulturen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für die Forscher, die die Methodologie der Zellkulturen in bezug auf die Deutung ihrer Ergebnisse benutzen, rufen Mycoplasmen, durch ihre häufige Gegenwart in Zellkulturen viele Probleme hervor. In der übersicht werden besprochen die Wirkungen auf den Zellstoffwechsel, auf Chromosomen, Transformationen in maligne Zellen, Anheftung an und Wechselwirkung mit der Zellmembran, intracelluläre Existenz. Beziehungen von Mycoplasmen und Viren, nachgewiesene Mycoplasmen-Arten in Zellkulturen und Methoden zu ihrer Feststellung.
    Notes: Summary The presence of mycoplasmas in tissue cultures has created many problems for investigators employing cell cultures, especially with respect to the interpretation of the results. It was partly because of these problems encountered in mycoplasma-infected tissue cultures that increased attention was paid to this group of organisms and many unique interactions of these organisms with cell cultures, uncultured living cells and viruses were discovered, which have been reviewed in the present paper.
    Type of Medium: Electronic Resource
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