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  • 1
    Electronic Resource
    Electronic Resource
    Effects of granulation tissue conditioned medium on the in vitro differentiation of keratinocytes (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 325-329 
    Details
    ISSN: 1434-4726
    Keywords: Cholesteatoma ; Terminal differentiation ; Transglutaminase ; Cell envelope
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accumulation of desquamated keratinizing squamous epithelial cells appears to be a crucial factor in the pathogenesis of middle ear cholesteatomas. The accumulation of keratin debris is due to the proliferation and the terminal differentiation of basal keratinocytes. Since cholesteatomas are usually associated with inflammatory reactions in the middle ear cavity, we examined the effects of a granulation tissue conditioned medium on the terminal differentiation of basal keratinocytes in vitro. This conditioned medium stimulated the terminal differentiation of basal keratinocytes by showing: (a) increased incorporation of 3H-leucine into cell envelopes; (b) an increased number of SDS-insoluble cell envelopes; and (c) increased transglutaminase activity (as a marker for terminal cellular differentiation). Our present studies further suggest that inflammatory granulation tissue plays an important role in the clinical growth and development of the cholesteatoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457987
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of human papillomavirus in cholesteatomas (2000)
    Springer
    European archives of oto-rhino-laryngology and head & neck 257 (2000), S. 120-123 
    Details
    ISSN: 1434-4726
    Keywords: Key words Cholesteatoma ; Middle ear infections ; Human papillomavirus ; Polymerase chain reaction ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presence of human papillomavirus DNA in cholesteatoma may have some role in the development of middle ear cholesteatoma as well as in papilloma. In the present study, polymerase chain reaction and in situ hybridization with human papillomavirus (HPV)-6 and ¶-11 DNA probes were used to detect the presence of HPV DNA in 32 human middle ear cholesteatomas. Only one specimen contained HPV-6 DNA. Although its occurrence may have been coincidental, it is also possible that the hyperproliferative epithelium of cholesteatomas might have some relationship with HPV infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050206
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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