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  • 1
    ISSN: 1439-6327
    Keywords: Heart rate deflection ; Lactate performance curve ; Plasma catecholamines ; Cycle ergometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The correlation between the behaviour of the heart rate/work performance (f c W) curve and blood lactate ([la]b) and plasma adrenaline/noradrenaline concentrations ([A]/[NA]) during incremental cycle ergometer exercise was investigated. A group of 21 male sports students was divided into two groups: group I, with a clear deflection of thef c W curve; group II, without or with an inverse deflection of thef c W curve. The aerobic threshold (Thaer) and the lactate turn point (LTP) were defined. Between Thaer and maximal work performance (f c W max) the behaviour of thef c W curve as well as the behaviour of [la−]b and [A]. [NA] were described mathematically. Thef c, systolic blood pressure (BPS),W, [la−]b, [A] and [NA] at rest, Thaer, LTP,f c W max, after 3 and 6 min of recovery (Re3/Re6) were calculated. A significant difference between the two groups could only be detected forf c at LTP, Re3 and Re6 (P 〈 0.05). No significant, correlation could be found between individualf c W-behaviour and individual time course of [la−]b, [A] and [NA]. However, a significant correlation was visible between [la−/W-behaviour and individual catecholamine response. These results and the fact that the different flattening at the top of thef c W curve was related to diminished stress-dependent myocardial function led us to the conclusion that it is possible that sympathetic drive is not directly involved in mechanisms of regulation between load dependentf c and myocardial function. In addition, individualf c W behaviour was independent of BPS andW max, or individual conditions of energy supply.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6327
    Keywords: Cycle ergometry ; Myocardial function ; Left ventricular ejection fraction ; Radionuclide ventricular scintigraphy ; Inflection of heart rate/performance curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The heart rate/work performance (f c/W) curve is usually S-shaped but a flattening at the top is not always seen. By means of radionuclide ventricular scintigraphy, the left ventricular ejection fraction (LVEF) of 15 sports students was investigated. The behaviour of the f c/W curve during cycle ergometry with increasing exercise intensities was examined. During exercise, the LVEF showed a distinct initial increase reaching roughly constant values at stress levels below-maximum, and sometimes even falling again. The inflections of the f c/W curve and left ventricular ejection fraction/performance curve (LVEFPC) were calculated from a second degree polynomial fit. From this function, the slopes of the tangents at the points of aerobic threshold and maximum performance were calculated together with the differences of the angles as a measure of the f c/W curve and LVEFPC inflections. It follows that the f c/W curve inflection became less pronounced or was even absent altogether when the decrease in LVEF towards the end of the ergometer exercise became more distinct. A significant negative correlation was found between the existence and extent of the f c/W curve inflection and the stress-dependent myocardial function, expressed as the inflection of the LVEFPC (P〈0.01, r=0.673). Thus, it would seem that the absence of a f c/W curve inflection was related to a diminished stress-dependent myocardial function.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 38 (1994), S. 338-346 
    ISSN: 1040-452X
    Keywords: Human sperm antigens ; Complement regulatory proteins ; Protectin CD59 ; Membrane attack complex ; Cell-to-cell adhesion ; Gametic interaction ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Protectin (CD59) is a complement regulatory protein which blocks the membrane attack complex during complement activation. CD59 was identifield on the human sperm surface by means of H19, an IgG1 anti-protectin mouse monoclonal antibody. Using Indirect immunofluorescence, flow cytometry and immunoperoxidase, CD59 was found to be present on the whole plasma membrane including the head and tail of fresh ejaculated, capacitated and acrosome-reacted spermatozoa. Immunoperoxidase staining of normal testicular sections indicated that this protein was already present on intraluminal germ cells. Analysis of this sperm protein by gel electrophoresis and immunoblotting revealed that its molecular weight of 20 kDa was comparable to that of CD59 expressed on peripheral blood cells (erythrocytes, lymphocytes) and that it was bound to the membrane through a glycophospholipid tail which could be released after treatment with phosphatidylinositol-specific phospholipase C. Associated to membrane cofactor protein (CD46) and decay accelerating factor (CD55) located in the acrosomal membranes, CD59 may participate to the protection of male gametes against complement-mediated damage as they travel through the female genital tract. Moreover CD59, known as an adhesion molecule involved in lymphocyte rosettes, may also participate in cell to cell adhesion during gametic interaction since H19 inhibited sperm binding and reduced the penetration rate and index during the hamster egg penetration test. © 1994 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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