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  • Immunostimulation  (2)
  • Purkinje cell inhibition  (2)
  • Cerebellum  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Neuronal activity in the lateral vestibular nucleus of the cat (1975)
    Springer
    Pflügers Archiv 360 (1975), S. 321-336 
    Details
    ISSN: 1432-2013
    Keywords: Deiters' nucleus ; Flexor reflex afferents ; Purkinje cell inhibition ; Positive field potentials ; Spino-olivocerebellar paths
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spatial distribution of inhibitory effects mediated by spino-olivocerebellar pathways and evoked by stimulation of the FRA was studied in Deiters' nucleus by intracellular recordings and extracellular measurements of positive field potentials. At a given recording site individual nerves greatly varied in their effectiveness: Q and Saph, Tib and FDL were usually the most effective, while GS had very little effect. When comparing several recording sites, various patterns of dominating and nondominating nerves were found, resulting in a somewhat patchy distribution of responses. The results were supported by intracellular recordings, which showed that CF-mediated IPSPs can be evoked from a limited number of nerves only. The findings show that a discriminative pattern exists in the FRA-evoked spino-olivocerebellar-mediated inhibition. In addition, Deiters neurones were found in which the inhibition was evoked from a large number of fore- and hindlimb nerves. Such a generalized inhibitory pattern may be involved in interlimb coordination during locomotion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579323
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neuronal activity in the lateral vestibular nucleus of the cat (1975)
    Springer
    Pflügers Archiv 360 (1975), S. 301-320 
    Details
    ISSN: 1432-2013
    Keywords: Cerebellar afferents ; Deiters neurones ; Postsynaptic potentials ; Purkinje cell inhibition ; Somatic afferents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The synaptic input to Deiters neurones evoked by stimulation of peripheral somatic nerves was measured by intracellular recordings. EPSPs with broad receptive fields and latencies which indicate polysynaptic connexions were commonly evoked from the FRA. In other cells, low threshold cutaneous afferents were effective at rather short latencies suggesting oligosynaptic connexions from fast ascending fibres. One example was found of EPSPs due to low threshold muscle afferents. IPSPs due to climbing fibre activation of Purkinje cells as observed in most of the neurones were evoked by cutaneous volleys above 1.5–2.0 T and muscle volleys above 5T (above 3–3.5T in case of Q). Often, IPSPs were evoked by stimulation of nerves, to the segmental level of which the vestibulospinal neurone under investigation projected. A small proportion of cells received short latency IPSPs involving direct fast mossy fibre tracts, which were evoked from low threshold cutaneous afferents. IPSPs due to polysynaptic mossy fibre activation of Purkinje cells were evoked from the FRA bilaterally and from ipsilateral cutaneous afferents at 1.5–2.0T (“prolonged inhibition”). Prolonged excitatory/inhibitory events mediated by mossy fibre pathways may be involved in quadruped locomotion or tother processes making use of a broad motor integration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579322
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neuronal activity in the lateral vestibular nucleus of the cat (1972)
    Springer
    Pflügers Archiv 337 (1972), S. 119-134 
    Details
    ISSN: 1432-2013
    Keywords: Deiters Neurones ; Excitation ; Inhibition ; Cerebellum ; Ascending Pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments were carried out on cats anesthetized with chloralose, small doses of Thiopental being added in about half of the animals. Recordings were made from neurones located in Deiters' nucleus. Single shocks applied to the spinal cord evoked membrane potential changes consisting of different types of PSPs. Current analysis revealed: EPSPs, IPSPs, and potential changes due to disinhibition; such components differing in their latencies. Upon stimulation at C2, there were EPSPs with brief (mean 1.7 ms) and longer (mean 5.8 ms) latencies, denoted “EE” and “CE”, respectively. Also, IPSPs showed up with brief (mean 3.6 ms, “MI”) and longer (mean 7.3 ms, “CI”) latencies. Moreover, there was a prolonged inhibition usually turning into a longlasting (up to several hundred milliseconds) disinhibitory depolarization. Of Deiters neurones exhibiting PSPs upon spinal cord stimulation, 66% showed the complete synaptic pattern, 34% short latency or long latency components in isolation. The patterns obtained intracellularly corresponded well to discharge patterns recorded extracellularly. The results were essentially similar in control experiments performed on precollicularly decerebrated cats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587835
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    372. Antigenstimulierte Gastrinfreisetzung in vitro (Mucosazellsuspension) (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 870-870 
    Details
    ISSN: 1435-2451
    Keywords: Gastrin ; Immunostimulation ; Gastrin ; Immunstimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Immunisierte Hunde zeigen eine antigenspezifische gastrale Verdauungsstimulation. Dieses Phänomen ließ sich nun erstmals in vitro (Zellsuspension) nachweisen. In der von evertierten Antren immunisierter Wistar-Ratten enzymatisch gewonnenen Mucosazellsuspension zeigte sich nach Inkubation mit Antigen (100 μg/ml) wie Interleukin 1 (70 E/ml) eine signifikante Gastrinfreisetzung (p 〉 0,05). Diese Tatsache spricht für das Vorliegen eines lokalen Immunmechanismus, der Antigene erkennt und funktionell mit dem endokrinen System gekoppelt ist.
    Notes: Summary Antigen-specific stimulation of gastric functions has been found in immunized dogs. This phenomenon has now been demonstrated in vitro (cell suspension) for the first time. Antral mucosa of everted gastric sacs from Wistar rats was removed enzymatically. Incubation with antigen (100 μg/ml), and also with Interleukin-I (70 U/ml) led to a significant release of gastrin (p 〈 0.05). These data appear to indicate a local immunological mechanism that can recognize antigens and is linked functionally with the endocrine system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274692
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    30. Immunologische reaktivität des magens - ein neuer mechanismus der ulcoprotektion (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 942-943 
    Details
    ISSN: 1435-2451
    Keywords: Peptic ulcer ; Immunostimulation ; Ulcer protection ; Peptisches Ulcus ; Immunstimulation ; Ulcoprotektion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine antigenspezifische Stimulation von Magenfunktionen ist in vivo und in vitro nachgewiesen. Die Bedeutung immunologischer Mechanismen für die Ulcogenese - Förderung oder Protektion - wurde im Modell alkoholinduzierter Schleimhautläsionen an Wistar-Ratten untersucht. Gegen NIP (Nitrophenylessigsäurederivat) immunisierten Tieren wurde das Antigen intragastral verabreicht, 15 min später 1 ml absoluter Alkohol. Die nach 1 h entstandenen Schleimhautläsionen wurden durch Summierung der Durchmesser der Einzelläsionen (Ulcusindex) bzw. pauschal (Ulcusscore) durch unabhängige Untersucher beurteilt. Gegenüber entsprechenden Kontrolltieren zeigten die antigenspezifisch stimulierten Tiere der Testgruppe signifikant (P〈0,02) weniger Läsionen. Damit konnte erstmals eine immunologisch vermittelte Ulcoprotektion gezeigt werden, die neue Ansätze in Pathophysiologie und Therapie der Ulcuserkrankung eröffnet.
    Notes: Summary Antigen-specific stimulation of gastric functions was demonstrated in vivo and in vitro. The role of this immunological mechanism in the development of peptic ulcers - enhancement or protection — was investigated using the model of alcohol-induced mucosal lesions. In immunized Wistar rats the antigen NIP (nitrophenylacetic acid) was injected into the stomach; 15 min later 1 ml pure alcohol was added. Mucosal lesions were assessed after 1 h, calculating the ulcer index or score. Immunized animals stimulated with the antigen showed significantly fewer (P〈0.02) lesions. Thus, for the first time protection from peptic ulcers was demonstrated by an immunological mechanism, pointing out a new aspect of pathophysiology or therapy in peptic ulcer disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298115
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    Paper (German National Licenses)
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