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  • 1
    Electronic Resource
    Electronic Resource
    Cerebral hemodynamics and “re-build-up” phenomenon on electroencephalogram in children with moyamoya disease (1995)
    Springer
    Child's nervous system 11 (1995), S. 214-219 
    Details
    ISSN: 1433-0350
    Keywords: Acetazolamine ; Cerebral blood flow ; Electroencephalogram ; Moyamoya disease ; Re-build up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract “Re-build-up” phenomenon, induced by hyperventilation, is a characteristic finding on electroencephalogram (EEG) in children with moyamoya disease, and suggests close correlation with cerebral ischemic attack. Its mechanism, however, remains obscure. In this study, we examined the relationship between the cerebral hemodynamics and this phenomenon before and after vascular reconstructive surgery. Regional cerebral blood flow and its reactivity to acetazolamide were analyzed using the xenon-133 inhalation method and single photon emission computed tomography in six children with moyamoya disease. These results were compared with the EEG. Regional vasoreactivity to acetazolamide was significantly lower in “re-build-up”-positive regions than in “re-build-up”-negative regions. Postoperative studies revealed a significant improvement of reactivity in the regions where the “re-build-up” phenomenon disappeared after surgery. These results suggest that the “re-build-up” phenomenon represents a focal reduction of the cerebral perfusion reserve in moyamoya disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277656
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Regional cerebral hemodynamics in childhood moyamoya disease (1995)
    Springer
    Child's nervous system 11 (1995), S. 584-590 
    Details
    ISSN: 1433-0350
    Keywords: Moyamova disease ; Cerebral ischemia ; SPECT ; Bypass surgery ; Cerebral blood flow ; Acetazolamide ; Frontal lobe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regional cerebral blood flow (rCBF) and its reactivity to acetazolamide were analyzed in a series of 15 cases of childhood moyamoya disease, using the xenon-133 inhalation method and single photon emission CT (SPECT). Most of the patients had normal mean hemispheric cerebral blood flow (mCBF), comparable to that of age-matched healthy children. However, they had abnormal rCBF distribution and disturbed reactivity to acetazolamide in the territory of the internal carotid artery, especially in the frontal lobe. Surgical revascularization for the anterior circulation, which consisted of STA-MCA anastomosis and indirect synangiosis, dramatically improved theses cerebral hemodynamics in the anterior circulation, including the frontal lobe, and reactivity to acetazolamide in the whole brain. These results suggest that surgical revascularization for the anterior circulation should be carried out in order to improve cerebral hemodynamics as widely as possible, especially in the frontal lobe, and may improve cerebral perfusion reserve in the posterior circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300997
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Regional cerebral blood flow in pediatric moyamoya disease: age-dependent decline in specific regions (1998)
    Springer
    Child's nervous system 14 (1998), S. 366-371 
    Details
    ISSN: 1433-0350
    Keywords: Key words Moyamoya disease ; Cerebral blood flow ; Aging ; Surgical treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirteen pediatric patients (ages 4–13 years) who underwent surgical treatment were examined regarding their rCBF in the preoperative periods. The postoperative rCBF was measured 39 times in these 13 patients. Thirteen healthy normal subjects (ages from 6 to 21 years) were also examined. The rCBF in the operculum and in the frontal, parietal, and occipital lobes was measured with 133Xe inhalation method and single photon emission computed tomography. In the parietal and occipital lobes, the preoperative rCBF had a negative and significant correlation with their ages, but not in the operculum or frontal lobe. However, subsequent to the surgical treatment, the rCBF increased significantly in the patients 5 years old or less, and then post-operative rCBF values had significant negative correlations with age in each region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050246
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebral hypoxia after hyperventilation causes “re-build-up” phenomenon and TIA in childhood moyamoya disease (1996)
    Springer
    Child's nervous system 12 (1996), S. 448-452 
    Details
    ISSN: 1433-0350
    Keywords: Moyamoya disease ; Re-build-up phenomenon ; Near-infrared spectroscopy ; Cerebral hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Near-infrared spectros-copy was used to monitor the sequential changes in the cerebral oxygenation state during and after hyperventilation in two children with moyamoya disease. Hyperventilation induced the build-up phenomenon and a decrease in the concentration of oxy-hemoglobin ([oxy-Hb]) and total hemoglobin ([t-Hb]). The termination of hyperventilation was followed by partial recovery of [oxy-Hb] and [t-Hb]. Subsequently, however, [oxy-Hb] and [t-Hb] decreased again and cytochrome oxidase was reduced. These impairments of the cerebral hemodynamics and oxygen metabolism were closely associated with the re-build-up phenomenon on EEG and with transient ischemic attacks (TIA). The present study implies that cerebral hypoxia after hyperventilation is closely related to the re-build-up phenomenon and ischemic attacks in children with moyamoya disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261621
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Familial occurrence of moyamoya disease (1994)
    Springer
    Child's nervous system 10 (1994), S. 421-425 
    Details
    ISSN: 1433-0350
    Keywords: Moyamoya disease ; Magnetic resonance angiography ; Familial occurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors report four cases of familial occurrence of moyamoya disease. Although the pathogenesis of moyamoya disease is not clear, there is extensive evidence that this disease has a tendency to show multifactorial inheritance. Therefore, a screening test for those at high risk, i.e., who have a moyamoya patient among their blood relatives, is clinically important. Magnetic resonance angiography (MRA) successfully revealed abnormal findings specific to moyamoya disease in members of the four probands families. MRA is a powerful and noninvasive way of detecting individuals at high risk of developing moymoya disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303605
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    Paper (German National Licenses)
    Fulltext
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