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  • 1
    Electronic Resource
    Electronic Resource
    Tetanus toxin does not affect the release of noradrenaline and taurine from rat cerebral cortex slices evoked by high K+ and Na+-free media (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 184-186 
    Details
    ISSN: 1420-9071
    Keywords: Brain slices ; noradrenaline ; taurine ; evoked release ; uptake ; tetanus toxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Noradrenaline and taurine release from superfused rat cerebral cortex slices was stimulated by potassium ions, veratrine, ouabain and omission of sodium ions. Tetanus toxin enhanced only the ouabain-evoked calcium-dependent noradrenaline release and the ouabain-evoked calcium-independent taurine release. The uptake of both was marginally affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01942844
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperphenylalanaemia and the exchange of tyrosine in adult rat brain (1971)
    Springer
    Experimental brain research 14 (1971), S. 48-60 
    Details
    ISSN: 1432-1106
    Keywords: Hyperphenylalanaemia ; Tyrosine ; Blood-brain exchange ; Cerebral protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An account is given of an experimental design and a computing procedure for in vivo measurement of the blood-tissue exchange of amino acids and the metabolic rate of tissue proteins with radioactively labelled amino acids. The method was used for evaluation of the exchange rates of tyrosine between the plasma and the brain and between the free and protein-bound tyrosine compartments in the brain of adult rats in experimental hyperphenylalanaemia and hypertyrosinaemia. Hyperphenylalanaemia inhibited the exchange of tyrosine between plasma and brain. In both hyperphenylalanaemic and hypertyrosinaemic rats the rate of synthesis of the cerebral proteins fell. Alterations in the intracerebral pool of free amino acids produced by excessive loading with phenylalanine or tyrosine are suggested as the cause of the impairment of cerebral protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234910
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Modification of chloride flux across brain membranes by inhibitory amino acids in developing and adult mice (1990)
    Springer
    Neurochemical research 15 (1990), S. 797-804 
    Details
    ISSN: 1573-6903
    Keywords: Chloride flux ; GABA ; taurine ; β-alanine ; hypoaurine ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influx of36Cl− was studied in membrane vesicles prepared from different brain regions from 3-day-old and adult mice. In both age groups the influx was enhanced about threefold by γ-aminobutyric acid (GABA), which effect was blocked by bicuculline and picrotoxin but not by baclofen, characteristic of a GABAA receptor-mediated event. In samples from the adult brain stem the GABA stimulation was smaller than in samples from the other brain regions. Most of the compounds studied apparently act at the same receptor site with the following order of efficacy: muscimol 〉 GABA 〉 β-alanine 〉 hypotaurine 〉 taurine. A number of anticonvulsant taurine derivatives were not effective and glycine only in the brain stem. The weak modulatory effects of taurine could be of significance in vivo since depolarizing stimuli release massive amounts of taurine in developing brain tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968557
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Sodium-independent taurine binding to brain synaptic membranes (1983)
    Springer
    Cellular and molecular neurobiology 3 (1983), S. 183-187 
    Details
    ISSN: 1573-6830
    Keywords: taurine ; synaptic membranes ; sodium-independent binding ; postsynaptic receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. 2. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. 3. Saturable taurine binding was displaceable by some convulsants and anticonvulsants but its specificity still remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735281
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    Paper (German National Licenses)
    Fulltext
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