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  • Chemistry  (10)
  • Cerulein  (3)
  • Dictyostelium discoideum  (3)
  • Differentiation  (2)
  • Glucose transporter  (2)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Precise expression of the cAMP receptor gene, CAR1, during transition from growth to differentiation in Dictyostelium discoideum
    Amsterdam : Elsevier
    FEBS Letters 342 (1994), S. 239-241 
    Details
    ISSN: 0014-5793
    Keywords: Cell cycle ; Dictyostelium ; Differentiation ; Putative shift (PS) point ; cAMP receptor 1
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80509-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of chronic intracerebroventricular infusion of vasoactive intestinal peptide (VIP) on memory processes in Morris water pool test in the rat
    Amsterdam : Elsevier
    Peptides 14 (1993), S. 1073-1078 
    Details
    ISSN: 0196-9781
    Keywords: Cerulein ; Memory ; Morris water pool test ; VIP ; VIP antagonist ; VIP(1-12)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(93)90089-Y
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Vasoactive intestinal peptide (VIP) causes memory impairment in passive avoidance responding of the rat
    Amsterdam : Elsevier
    Peptides 14 (1993), S. 1067-1071 
    Details
    ISSN: 0196-9781
    Keywords: Cerulein ; Memory ; Passive avoidance response ; VIP ; VIP antagonist
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(93)90088-X
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Protective effect of cerulein on memory impairment induced by protein synthesis inhibitors in rats
    Amsterdam : Elsevier
    Peptides 13 (1992), S. 1007-1012 
    Details
    ISSN: 0196-9781
    Keywords: Active avoidance ; Anisomycin ; Cerulein ; Cycloheximide ; Morris water maze ; Passive avoidance ; Puromycin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(92)90063-9
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The developmental fate of dictyostelium discoideum cells depends greatly on the cell-cycle position at the onset of starvation
    Amsterdam : Elsevier
    Cell Differentiation 22 (1987), S. 11-18 
    Details
    ISSN: 0045-6039
    Keywords: Cell adhesion ; Cell cycle ; Cell sorting ; Chemotaxis ; Development ; Dictyostelium discoideum
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0045-6039(87)90409-X
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  • 6
    Electronic Resource
    Electronic Resource
    Glucose transporter gene expression in rat conceptus during high glucose culture (1993)
    Springer
    Diabetologia 36 (1993), S. 696-706 
    Details
    ISSN: 1432-0428
    Keywords: Glucose transporter ; embryogenesis ; hyperglycaemia ; rat embryo culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the expression of glucose transporter genes and protein in embryo and yolk sac during organogenesis and the regulation of glucose transporters during culture in hyperglycaemic media. Erythrocyte-type glucose transporter (GLUT 1) and brain-type glucose transporter (GLUT 3) mRNA were expressed in embryo and yolk sac. The expression of GLUT-1 and GLUT-3 mRNA was abundant on day 9–11 and day 9–10 in the embryo, respectively, and day 9–14 and day 10–11 in the yolk sac, respectively. The levels of GLUT-1 protein in the embryo increased in parallel with the expression of GLUT-1 mRNA during the corresponding period. Immunohistochemical staining of GLUT-1 protein was found principally in the neuroepithelial cells surrounding the neural tube in the embryo on day 10 and appeared in the microvessels surrounding the neural tube after day 12. To test whether the expression of glucose transporter genes and protein was suppressed during hyperglycaemia, conceptuses were cultured in high glucose medium. The abundant expression of GLUT-1 protein was not decreased during culture in high glucose media for 24 h (day 9–10) and was only down-regulated by prolonged exposure to this media for 48 h (day 9–11). We have demonstrated the predominant expression of the high affinity glucose transporter (GLUT 1 and GLUT 3) genes and (GLUT 1) protein in embryo during the early period of organogenesis. The persistently abundant expression of glucose transporter during the critical period of neural tube formation (day 9–10) even in the presence of hyperglycaemia may explain one of the mechanisms of increased glucose flux into the neuroepithelium, which may lead to neural tube defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401139
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  • 7
    Electronic Resource
    Electronic Resource
    Glucose transporter gene expression in rat conceptus during early organogenesis and exposure to insulin-induced hypoglycemic serum (1993)
    Springer
    Acta diabetologica 30 (1993), S. 73-78 
    Details
    ISSN: 1432-5233
    Keywords: Embryogenesis ; Glucose transporter ; Growth retardation ; Hypoglycemia ; Neural tube defect ; Rat embryo culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the glucose transporter gene and protein expression during early organogenesis in the rat and in rat embryos cultured with hypoglycemic serum. Erythrocyte-type glucose transporter (GLUT-1) mRNA was expressed at a high level in embryos; peak levels were reached at days 10.5–11.5 and decreased as gestational age increased. In contrast, the insulin regulaable glucose transporter (GLUT-4) mRNA was not detected. The levels of GLUT-1 protein determined by Western blot analysis increased in parallel with expression of the glucose transporter (GLUT-1) gene and peak levels were observed on days 10.5 and 11.5, which correspond to the main periods of neural tube formation. Immunohistochemical staining of the embryo on day 10.5 showed that GLUT-1 protein was abundantly located in the tissue of neural tube. When embryos were cultured from day 9.5 to day 10.5 with insulin-induced hypoglycemic serum containing 2–3 mM glucose an increased frequency of anterior neural tube defects was observed in association with a significant reduction of the glycolytic flux. Increased levels of GLUT-1 mRNA and protein were not observed during the culture with hypoglycemic serum compared with the levels in embryos cultured in normal serum. Addition of insulin to normal serum (500 μU/ml) did not affect the GLUT-1 mRNA and protein levels. GLUT-1 mRNA and protein are strongly expressed in the embryo during early organogenesis, especially in the tissues of the neural tube, and the expression of the glucose transporter did not increase in response to prolonged glycopenia. This may account for the vulnerability of embryogenesis to hypoglycemia during these critical developmental periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578217
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  • 8
    Electronic Resource
    Electronic Resource
    Development of an autophagic system in differentiating cells of the cellular slime moldDictyostelium discoideum (1981)
    Springer
    Protoplasma 108 (1981), S. 55-69 
    Details
    ISSN: 1615-6102
    Keywords: Acid phosphatase ; Autophagic vacuole ; Cytochemistry ; Dictyostelium discoideum ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Changes in an autophagic system during differentiation of cells ofDictyostelium discoideum, NC-4 were studied under light and electron microscopes, and it was demonstrated cytochemically that acid phosphatase was almost exclusively localized in food and autophagic vacuoles. Autophagic vacuoles first appeared during formation of loose aggregates, coupled with the defecation of food vacuoles. Autophagic vacuoles seem to originate from flat sacs which segregate parts of the cytoplasm. No acid phosphatase was detected in the vacuoles when first formed, but activity appeared later probably due to fusion with Golgi-like vesicles. When starved cells were not allowed to aggregate due to a low cell density, they formed no autophagic vacuoles but retained many food vacuoles. This indicates that the formation of autophagic vacuoles is not simply due to starvation, but to cell interaction mediated by cell contact. Autophagic vacuoles containing acid phosphatase rapidly increased in number in all cells in the early stage of aggregation. After papillae formed, however, they selectively decreased in the prespore cells, but developed further and grew larger in the prestalk cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276883
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Development of prespore vacuoles inDictyostelium cells differentiating in a liquid shake culture (1984)
    Springer
    Protoplasma 123 (1984), S. 152-159 
    Details
    ISSN: 1615-6102
    Keywords: Cellular slime mold ; Dictyostelium discoideum ; Development ; Electronmicroscopy ; Golgi apparatus ; Prespore vacuole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When shaken in a glucose-albumin-cyclic AMP medium, dissociated aggregative cells form small clumps in which prespore cells differentiate fairly synchronously (Okamoto 1981). Formation of prespore vacuoles (PSVs) in differentiating prespore cells was examined in these culture conditions, by electronmicroscopy and immunocytochemistry. After 6 hours of culture, a typical Golgi apparatus composed of vesicles and stacked flat cisternae develops near the nucleus. FITC-conjugated antispore serum stains a crescent-shaped region in the cells which seems to correspond to the Golgi area. After 9 hours, flat sacs which contain electron dense lining membrane similar to that of PSVs appear alongside Golgi cisternae. Later, partially and fully round PSVs are observed in this region, suggesting that flat sacs round up to become mature PSVs. After 12 hours, as mature PSVs increase in number, they become dispersed throughout the cytoplasm and a typical Golgi apparatus with cisternae disappears. When cultured in a medium devoid of cyclic AMP, cells develop neither Golgi cisternae nor PSVs. These results strongly suggest that PSVs form from Golgi cisternae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01283585
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  • 10
    Electronic Resource
    Electronic Resource
    Gas permeation in polyethersulfone (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 33 (1987), S. 1823-1828 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070330533
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