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  • 1
    ISSN: 1619-7089
    Keywords: Partition model ; Clinical evaluation ; Yttrium-90 microspheres ; Hepatic cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiation doses to the tumour and non-tumorous liver compartments from yttrium-90 microspheres in the treatment of hepatic cancer, as estimated by a partition model, have been verified by correlation with the actual doses measured with a beta probe at open surgery. The validity of the doses to the lungs, the tumour and non-tumorous liver compartment as estimated by the partition model was further evaluated in clinical settings. On the basis of the observation that one of three patients who received more than 30 Gy from a single treatment and one of two patients who received more than 50 Gy from multiple treatments developed radiation pneumonitis, it was deduced that an estimated lung dose 〈30 Gy from a single treatment and a cumulative lung dose 〈50 Gy from multiple treatments were probably the tolerance limits of the lungs. Three of five patients who received lung doses 〉30 Gy as estimated by the partition model and were predicted to develop radiation pneumonitis, did so despite the use of partial hepatic embolization to reduce the degree of lung shunting. Furthermore, a higher radiological response rate and prolonged survival were found in the group of patients who received higher tumour doses, as estimated by the partition model, than in the group with lower estimated tumour doses. Thus the radiation doses estimated by the partition model can be used to predict (a) complication rate, (b) response rate and (c) duration of survival in the same manner as the actual radiation doses measured with a beta probe at open surgery. The partition model has made selective internal radiation therapy using90Y microspheres safe and repeatable without laparotomy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Key words: Partition model ; Clinical evaluation ; Yttrium-90 microspheres ; Hepatic cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Radiation doses to the tumour and non-tumorous liver compartments from yttrium-90 microspheres in the treatment of hepatic cancer, as estimated by a partition model, have been verified by correlation with the actual doses measured with a beta probe at open surgery. The validity of the doses to the lungs, the tumour and non-tumorous liver compartment as estimated by the partition model was further evaluated in clinical settings. On the basis of the observation that one of three patients who received more than 30 Gy from a single treatment and one of two patients who received more than 50 Gy from multiple treatments developed radiation pneumonitis, it was deduced that an estimated lung dose 〈30 Gy from a single treatment and a cumulative lung dose 〈50 Gy from multiple treatments were probably the tolerance limits of the lungs. Three of five patients who received lung doses 〉30 Gy as estimated by the partition model and were predicted to develop radiation pneumonitis, did so despite the use of partial hepatic embolization to reduce the degree of lung shunting. Furthermore, a higher radiological response rate and prolonged survival were found in the group of patients who received higher tumour doses, as estimated by the partition model, than in the group with lower estimated tumour doses. Thus the radiation doses estimated by the partition model can be used to predict (a) complication rate, (b) response rate and (c) duration of survival in the same manner as the actual radiation doses measured with a beta probe at open surgery. The partition model has made selective internal radiation therapy using 90Y microspheres safe and repeatable without laparotomy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 12 (1966), S. 1225-1227 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 29 (1989), S. 1177-1181 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The thermo-oxidative aging of a polyether urethane lightguide primary coating has been studied in films and dual-coated fibers, In films, oxygen absorption is correlated with changes in modulus, yellowness, glass transition temperature, and sample weight. Thermal aging of fibers shows similar trends with regards to coating weight loss and discoloration as those observed with films. In addition, the force to mechanically strip the fiber follows the same patterns of change as the modulus of aged films. For both films and fibers, the time for onset of property changes varies inversely with temperature and can be delayed by the incorporation of an antioxidant.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 14 (1974), S. 12-15 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: By incorporating the spectroscopic techniques of reflection-absorption and internal reflection in the infrared region, we have been able to define and characterize overall chemical changes occurring at a metal-polymer interface. Our initial studies have concentrated on the oxidative degradation of metal-polymer systems. These systems are of particular importance because of the common need to retard the metal-catalyzed degradation of the polymer. Preliminary results for copper-polyethylene interfaces, models for polyolefin-insulated cable, have shown the copper surface to be the site of the initial catalysis in the oxidation of the polyethylene. When copper deactivators are added to inhibit the oxidation, initial reactions between the copper surface and the inhibitor can be seen. The importance of these surface reactions highlights the necessity for studying the interface.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 21 (1981), S. 1019-1026 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The concepts of linear elastic fracture mechanics (LEFM) are applied to three grades of high density polyethylene in an attempt to determine their fracture behavior in terms of a linear elastic fracture toughness, Kc. The effect of specimen size (thickness and width), crack length and the mode of loading on Kc has been investigated in order to determine the plane strain fracture toughness, KIc, of these materials. The effect of temperature (between +23 and -180°C) on their fracture behavior has also been investigated and compared in terms of their plane strain fracture toughness values.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 11 (1971), S. 377-380 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The thermal stability of polyethylene containing conventional antioxidants is adversely affected by contact with copper, by certain pigments, and by the addition of a few percent of polypropylene as a processing aid. Polyethylene inhibited with 0.1% of phenolic antioxidants has approximately the same oxidative stability when in contact with a copper surface as the unprotected polymer. A mechanism is suggested to account for the loss of stability in the presence of copper. Pigments vary in the extent to which they adversely affect the oxidative stability of polyethylene. Since several factors may combine to decrease the stability of protected polyethylene compositions, as determined by accelerated tests, it is essential that their contribution under service conditions be determined. The predicted life at temperatures encountered in service is determined by extrapolating accelerated test data to that constant temperature which is calculated to cause the same degree of degradation as would occur during the daily and seasonal temperature cycles encountered in use.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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