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Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline (1983)

Ogura, C. ; Kishimoto, A. ; Mizukawa, R. ; [et al.]

Springer

European journal of clinical pharmacology 25 (1983), S. 811-814

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ISSN: 1432-1041

Keywords: age difference ; antidepressants ; blood pressure ; flicker fusion frequency ; salivation ; pharmacokinetics ; dothiepin ; pharmacodynamics ; amitriptyline

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Blood pressure, critical flicker fusion frequency (CFF), salivary flow rate and pharmacokinetics were compared in 7 young healthy volunteers (average age: 22.7 years) and in 7 elderly healthy volunteers (average age: 70.6 years) after single oral doses of the antidepressants dothiepin (DP) 25 mg and amitriptyline (AMP) 25 mg. Systolic blood pressure fell further and the reduction lasted longer in the elderly than in the young after both drugs. The decrease in CFF after AMP 25 mg, and the reduction in salivary flow rate after either DP 25 mg or AMP 25 mg were larger in the elderly than in the young. Plasma levels, T1/2 and Cl of both drugs in the elderly were also higher, longer and smaller, respectively, in the elderly. Clearance was found to be reduced in the elderly. More cautions dosage regimens of these drug should be considered for elderly patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542525

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Processability of high-density polyethylene bottles with special reference to melt flow properties (1970)

Hirata, S. ; Kishimoto, A.

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 10 (1970), S. 235-240

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ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: A phenomenological treatment has been developed for correlations between melt flow properties of high-density polyethylenes and the processability of bottles. Defining two parameters for the flow properties, it was found experimentally that linear relationships hold satisfactorily between these flow parameters for the raw materials and those of corresponding extrudates. Several kinds of defects in high-density polyethylene bottles can be represented in terms of the flow parameters. These parameters may provide useful measures in predicting good appearance of bottles blow-molded with high-density polyethylene.

Additional Material: 11 Ill.