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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 11 (1999), S. 3793-3807 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The multiple-time-scale concept is applied to develop a turbulence model for compressible flows. Transport equations for the turbulent kinetic energies and the energy transfer rates are linked to each domain of the turbulent spectrum. The model coefficients are calibrated, with respect to simple flows, by using a new method which takes advantage of the spectral character of the model. One innovation of this method is to use, as a component, the CG model [V. M. Canuto and I. Goldman, Phys. Rev. Lett. 54, 430 (1985)] which gives the large scale spectrum as a function of the instability-generating turbulence. Then, the two-time-scale model, with its complete set of coefficients, has been successfully applied to the simulation of plane mixing layers and homogeneous shear flows. A significant issue of this work is the study of the behavior of the two-time-scale model when a shock wave interacts with a homogeneous turbulence. We first compare model results with experimental data for a 2.8 Mach number interaction [D. Alem, Ph.D. thesis, Université de Poitiers, 1995]. The decrease of the integral length scale, predicted by the linear analysis, is reproduced with the two-time-scale model, which, moreover, recovered the rate of reduction measured by Alem. The amplification of the turbulence level through the shock wave is also consistent with the measurements. Then, we confront our results with a direct numerical simulation of the shock–turbulence interaction at M=1.2 [S. Lee et al., J. Fluid Mech. 251, 533 (1993)]. The spectrum of the turbulence injected in the inflow region of the direct numerical simulation appeared to be far from the freely decaying state. The two-time-scale model, which accounts for the spectral nonequilibrium effects, is able to recover the spatial decrease of turbulence in the inflow region whereas a single-time-scale model fails. Moreover, the profiles for the turbulent kinetic energy and its dissipation rate over all the calculation domain are much better reproduced with the two-time-scale model than with the primary k–cursive-epsilon model. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 58 (1992), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have recently reported on the differential alterations of various cholinergic markers in cortical and subcortical regions in Alzheimer's disease (AD). The main purpose of the present study was to determine if cholinergic deficits observed in patients with AD are unique to this disorder or can be generalized to others such as idiopathic Parkinson's disease (PD) and PD with Alzheimer-type dementia (PD/AD). Muscarinic M1, M2, and nicotinic receptor binding parameters (Kd and Bmax) were determined in various cortical and subcortical areas using selective radioligands ([3H]-pirenzepine, [3H]AF-DX 116, and N[3H]methylcarbamylcholine). Choline acetyltransferase activity was also determined as a marker of the integrity of cholinergic innervation. Alterations of cholinergic markers are comparable in cortical areas in AD, PD, and PD/AD brains. In frontal and temporal cortices, as well as in the hippocampus, choline acetyltransferase activity and binding capacities of M2 and nicotinic binding sites are similarly decreased in these three disorders compared with age-matched control values. M1 receptor binding parameters are not significantly modified in cortical areas in patients with these disorders. In contrast, important differences between AD and PD brain tissues are found in subcortical areas such as the striatum and the thalamus. The density of M1 sites is significantly increased in striatal areas only in patients with AD, whereas densities of nicotinic sites are decreased in thalamus and striatum in PD and PD/AD, but not AD, brain tissues. The binding capacity of M2 sites is apparently unchanged in subcortical areas in all three disorders, although tendencies toward reductions are observed in the striatum of PD and PD/AD patients. Thus, although comparable alterations of various cholinergic markers are observed in cortical areas in the three neurological disorders investigated in the present study, important differences are seen in subcortical areas. This may be relevant to the respective etiological and clinical profiles of AD and PD.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The main objective of the present study was to determine whether cholinergic markers (choline acetyl-transferase activity and nicotinic and muscarinic receptors) are altered in Alzheimer's disease. Choline acetyltransferase activity in Alzheimer's brains was markedly reduced in various cortical areas, in the hippocampus, and in the nucleus basalis of Meynert. The maximal density of nicotinic sites, measured using the novel nicotinic radioligand N-[3H]methylcarbamylcholine, was decreased in cortical areas and hippocampus but not in subcortical regions. M1 muscarinic cholinergic receptor sites were assessed using [3H]pirenzepine as a selective ligand; [3H]pirenzepine binding parameters were not altered in most cortical and subcortical structures, although the density of sites was modestly increased in the hippocampus and striatum. Finally, M2-like muscarinic sites were studied using [3H]-acetylcholine, under muscarinic conditions. In contrast to M1 muscarinic sites, the maximal density of M2-like muscarinic sites was markedly reduced in all cortical areas and hippocampus but was not altered in subcortical structures. These findings reveal an apparently selective alteration in the densities of putative nicotinic and muscarinic M2, but not M1, receptor sites in cortical areas and in the hippocampus in Alzheimer's disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 3652-3660 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The relaxation of an atomic force microscope microlever is investigated after the unsticking instability. We show that the different oscillating behavior can be explained by considering that polymer chains remain stuck at the tip even when the microlever is away from the sample. A simple rheological model is used which satisfactorily describes the different features observed. The approach described in the article provides useful additional information to understand the behavior of a microlever coupled to a polymer network. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 22 (1989), S. 2213-2218 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 61 (2002), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Acoustic methods were used to study Atlantic redfishes Sebastes spp. vertical migration and shoaling behaviour in Newfoundland waters. Redfishes exhibited consistent patterns of vertical migration in winter, spring and summer, but pelagic shoals were not observed in winter. Pelagic daytime aggregations were generally in close proximity to dense patches of redfishes along the sea floor. Pelagic shoals exhibited high degrees of variability in size, shape and density. Attempts to explain variations in shoal density and area with features of shoal position and structure were unsuccessful. Nearest neighbour distance between fish in shoals had a lower limit near one body length. During the night, fishes were dispersed in the water column and distributions were more homogenous. Diel vertical migration appeared to be a foraging strategy, in which redfishes followed the migration of their euphausiid prey.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The validity of a hydroacoustic procedure was assessed using a combination of horizontal and vertical scanning to map the distribution of targets and to estimate target density in a shallow lake. Three distribution patterns were created using 37–50 artificial targets (metal hex nuts) anchored at known positions. Real and acoustic maps were qualitatively similar. Aggregation indices estimated by hydroacoustics were within 15% of the real values. Target density ranged from 1 to 8 targets per 100 m−3. Estimated target densities were within one target of the real values for 88% of our observations. The variable angle approach was used also to monitor daily and seasonal variations in fish distribution and relative abundance outside the littoral zone. Dace Phoxinus eos × P. neogaeus appeared to use the littoral as a refuge during the day and to migrate to the pelagic zone at dusk. The movements of dace outside the littoral zone were limited to the months of June-August. The variable angle acoustic approach can be useful to estimate fish distribution and relative abundance in shallow lakes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 51 (1986), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An in vitro digestion method was proposed for studying protein digestion. Protein (casein) was submitted to peptic proteolysis in a closed system followed by hydrolysis with pancreatic enzymes in a “digestion cell” with continuous elimination of digested products by dialysis. The peptic digestion was performed with a pepsin source of high specific activity (3152 units/mg protein) with an enzyme:substrate (E:S) ratio of 1: 250. The second-step of proteolysis was carried out with pancreatin for 6 hr at an E:S ratio of 1:25. A 10 mM sodium phosphate buffer, pH 7.5, was used as the circulating dialysis buffer.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 51 (1986), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A dialysis cell was devised to study in vitro digestion of proteins. The inner reaction vessel (surrounded by a tubular membrane with molecular weight cutoff of 1000) was fixed into a cylindrical outer compartment where buffer circulation was provided. The dimensions of compartments, membranes and buffer flow rate were determined with labelled amino acids in order to ensure the most efficient diffusion pattern. For the digestion assay, casein was first hydrolyzed with pepsin (pH 1.9) for 30 min. The mixture was then made alkaline (pH 7.5) and poured into the dialysis tube with pancreatin. Nitrogenous material collected with the sodium phosphate buffer was analyzed without further fractionation for the direct measurement of hydrolysis kinetic or of protein digestibility.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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