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  • Chemistry  (6)
  • Renal scarring  (3)
  • Copolymers  (2)
  • Engineering General  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Block copolymerization of α-amino acid N-carboxyanhydride initiated by vinyl polymers having a terminal amino group and the characterization of the block copolymers
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 7 (1985), S. 173-181 
    Details
    ISSN: 0141-8130
    Keywords: Copolymers ; block copolymerization ; terminally aminated poly(methyl methacrylate) ; terminally aminated polystyrene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0141-8130(85)90021-2
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  • 2
    Electronic Resource
    Electronic Resource
    Block copolymerization of vinyl compounds by the terminal-group activation of poly(α-amino acids) and the characterization of block copolymers
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 7 (1985), S. 89-99 
    Details
    ISSN: 0141-8130
    Keywords: Copolymers ; antithrombogenicity ; block copolymerization ; metal carbonyl ; methyl methacrylate ; protein adsorption ; styrene ; surface morphology ; terminally haloacetylated poly(α-amino acid)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0141-8130(85)90037-6
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of prednisolone on ascending renal infection due to biofilm disease and lower urinary tract obstruction in rats (1995)
    Springer
    Urological research 22 (1995), S. 383-387 
    Details
    ISSN: 1434-0879
    Keywords: Lower urinary tract obstruction ; Biofilm disease ; Renal scarring ; Prednisolone ; Ciprofloxacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A model of renal infection due to lower urinary tract obstruction and biofilm disease was constructed for the study of renal scarring by inserting glass beads coated with bacterial biofilm into the bladder of rats and then clamping the urethra. We previously reported the effect of antimicrobial therapy used in combination with the anti-inflammatory agent prednisolone to prevent renal scarring. In this study we investigated the effect of prednisolone on renal scar formation using our new model. Renal scarring could not be prevented in the group in which prednisolone was administered in the period during which the urethra was regularly being clamped. In contrast, scarring was prevented in the group that began to receive prednisolone after the period of clamping had ended. Therefore, in cases of lower urinary tract obstruction prednisolone should only be administered for the prevention of renal scarrring after the obstruction has been resolved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296880
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  • 4
    Electronic Resource
    Electronic Resource
    Increased renal scarring by bacteria with mannose-sensitive pili (1990)
    Springer
    Urological research 18 (1990), S. 299-303 
    Details
    ISSN: 1434-0879
    Keywords: MS pili ; Serratia marcescens ; Renal scarring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal scars are thought to be the end stage of chronic pyelonephritis and one of the most important causes of renal insufficiency and renal hypertension. The role of bacterial pili was examined in scar formation after an infection of newly constructed bacterial strains using the recombinant DNA technique, which possessed either mannose resistant (MR) or mannose sensitive (MS) pili of Serratia marcescens. Strains that differed in only a single virulence factor, namely, MR or MS pili, were used in a rat model of chronic pyelonephritis. In this model, MS-piliated bacteria stimulated renal scarring more severely than non-piliated or MR-piliated bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300774
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  • 5
    Electronic Resource
    Electronic Resource
    Role of superoxide in renal scarring following infection by mannose-sensitive piliated bacteria (1991)
    Springer
    Urological research 19 (1991), S. 229-233 
    Details
    ISSN: 1434-0879
    Keywords: Pyelonephritis ; Renal scarring ; Pathogenesis ; Serratia marcescens ; Piliation ; Superoxide dismutase ; Leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of superoxide in scar formation following renal infection caused by mannose-sensitive (MS) piliated strains of bacteria was studied in the experimental pyelonephritis model using female Sprague-Dawley rats. The MS piliated strain stimulated renal scarring to a significantly greater extent than either the non-piliated or MR-piliated strain. Modulation of leukocytes by administering cyclophosphamide to induce neutropenia and colchicine to inhibit leukocyte migration was effective in preventing renal scarring. Treatment with superoxide dismutase during the early stage of infection was also effective in preventing scar formation. Finally, the production of superoxide by rat leukocytes was significantly larger following stimulation by MS piliated than either the nonpiliated or MR piliated strains. These observations suggest that superoxide released from leukocytes plays a critical role in the development of renal scarring following a bacterial infection, especially by MS piliated strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305300
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  • 6
    Electronic Resource
    Electronic Resource
    Thermal conductivity of a polymer composite filled with mixtures of particles (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 34 (1987), S. 1429-1437 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A new thermal conduction model is proposed for a polymer system filled with a mixture of several types of particles. Predicted values by the new model are compared with experimental data. The model is derived by extending a model that was previously proposed for a two-phase system. The following equation is derived from the new model: log λ = V · (X2 · C2 · log λ2 + X3 · C3 · log λ3 + (1 - V) log (C1 · λ1. When the thermal conductivities of polymer and particles (λ1, λ2, λ3, …) and a mixing ratio of particles (X2, X3, …) are known, thermal conductivity of the filled polymer (λ) with several types of particles can be estimated from the equation, with any volume content of particles (V). Furthermore, from each polymer-filler composite (two-phase system) data, the thermal conductivity of a composite filled with different filler particles can be estimated.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070340408
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation of the polymer bearing pendant quinonoid groups by UV irradiation and its photocrosslinking (1987)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 25 (1987), S. 3173-3176 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1987.080251119
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  • 8
    Electronic Resource
    Electronic Resource
    Boundary-element solution of some structural-acoustic coupling problems using the multiple reciprocity method (1994)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 10 (1994), S. 237-248 
    Details
    ISSN: 1069-8299
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In the paper we have developed a new formulation for solution of structural-acoustic coupling problems by boundary elements using the multiple reciprocity method. It is assumed that the structure is composed of plate components and is excited by the external or the internal noise source. The efficiency of the proposed formulation becomes especially remarkable if the boundary-value problem is to be solved repeatedly for different values of frequency. The accuracy of the numerical computations has been compared with the analytical solution in a test example.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1640100307
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  • 9
    Electronic Resource
    Electronic Resource
    Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole - a preliminary study (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 17-21 
    Details
    ISSN: 0899-0042
    Keywords: proton pump inhibitor ; pantoprazole ; stereoselective pharmacokinetics ; genetic polymorphism ; human ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Pantoprazole (PAN) is a proton pump inhibitor that is administered as a racemic mixture. The pharmacokinetics of PAN enantiomers were investigated in extensive metabolizers (EMs) and apparent poor metabolizers (PMs) of PAN who received a single 40, 60, or 80 mg oral dose of racemic PAN as enteric-coated formulation. In the EMs, the serum concentrations of (-)-PAN were slightly higher than those of (+)-PAN at each dose level. The (+)/(-) ratios for the area under the concentration-time curve (AUC) and the half-life were 0.58-0.89 and 0.62-0.88, respectively. In the PMs, the serum concentrations of both enantiomers were much higher than those in the EMs at each dose level and significant differences in pharmacokinetics of (+)- and (-)-PAN were observed. The half-lives for (+)-PAN were 2.67-3.77 times longer than those for (-)-PAN. The AUCs for (+)-PAN were 2.65-3.45 times greater than those for (-)-PAN. Therefore, the metabolism of (+)-PAN is impaired to a greater extent than (-)-PAN in the PMs, which resulted in the stereoselective disposition of PAN in the PMs. It has been suggested that the EMs and the PMs of PAN could be differentiated by determining the (+)/(-) enantiomer ratio in serum at one time point, possibly 2-6 h after oral dosing, because the (+)/(-) enantiomer ratios in the PMs were opposite those in the EM subjects. Chirality 9:17-21, 1997 © 1997 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Luminescence biosensors (1989)
    New York : Wiley-Blackwell
    Journal of Bioluminescence and Chemiluminescence 4 (1989), S. 535-542 
    Details
    ISSN: 0884-3996
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A novel optical biosensor for homogeneous immunoassay has been developed on the basis of the finding that electrochemical luminescence of pyrene-labelled antigen is extremely inhibited by immunochemical complexation. Electrochemical luminescence homogeneous immunoassay for human serum albumin (HSA), as a model analyte, was performed with a platinum plate electrode which was located in the vicinity of an optical fibre tip. HSA was determined in the concentration range of 3-25 × 10-6 mol/I.To improve electrochemical luminescence measurement an optical fibre electrode has been developed by fabricating a transparent platinum film on the top of an optical fibre. The minimum detectable limit of luminol was 10-11 mol/l with the optical fibre electrode. Luminol was applied as a label for homogeneous immunoassay.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bio.1170040170
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