ISSN:
1590-3478
Keywords:
Myotonic dystrophy
;
cognitive function
;
psychiatric diagnosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Sommario Abbiamo valutato, in 40 pazienti affetti da forma severa di distrofia miotonica (MD), i disturbi cognitivi e i sintomi psichiatrici mediante test neuropsicologici (WAIS-R, MMSE) e mediante intervista semistrutturata e scala di autovalutazione (SADS, SRT). Come controllo abbiamo utilizzato 20 controlli sani. I pazienti con MD avevano punteggi significativamente più bassi di QI totale (p〈0.001), Verbale (p〈0.001) e non-Verbale (p〈0.001) del WAIS-R e al MMSE (p〈0.05) rispetto ai controlli. Il trentacinque per cento dei pazienti aveva una diagnosi psichica, di cui 17.5% avevano disturbi depressivi. I nostri dati confermano che i disturbi cognitivi e psichiatrici sono una manifestazione clinica importante nella distrofia miotonica.
Notes:
Abstract We evaluated 40 patients suffering from a severe form a myotonic dystrophy (MD) with neuropsychological (WAIS-R, MMSE) and psychiatric tests (SADS, SRT) for the assessment of cognitive and psychiatric symptoms. We tested 20 normal volunteers as control group. Patients with MD scored significantly, lower on WAIS Full Scale (p〈0.001), Verbal Scale (p〈0.001), and Performance Scale (p〈0.001) and on the MMSE (p〈0.05) than the controls. 35% of patients met the Research Diagnostic Criteria for a psychiatric diagnosis; 17.5% of them had a depressive disorder. The scores on SADS subscales and on the SRT scale of depression were also significantly higher in patients than in controls. Our data confirm that mental impairment and psychiatric disorders are important clinical manifestations of CNS dysfunction in the severe form on MD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02222889
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