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  • 1
    Electronic Resource
    Electronic Resource
    Ability of 3-carboxysalsolinol to produce ethanol-like discrimination in rats (1980)
    Springer
    Psychopharmacology 68 (1980), S. 277-281 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Ethanol ; Apomorphine ; Salsolinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of the present study was to investigate the possible generalization to 3-carboxysalsolinol (3C-SAL) in a group of rats trained to discriminate a low dose of ethanol (200 mg/kg IP) from the nondrug condition and in another group trained to discriminate 0.16 mg/kg IP apomorphine (AP) from the nondrug condition using a drug discrimination paradigm. In test sessions, ED50 for ethanol was 52.0 mg/kg and ED50 for AP was 0.01 mg/kg. In the ethanol-trained rats, 1.8 mg/kg 3C-SAL produced drug responses. In the AP-trained rats, 200 mg/kg ethanol produced drug responses whereas 1.8 mg/kg 3C-SAL produced only a partial drug response. The results are in harmony with the hypothesis that salsolinol in the central nervous system of the rat may be responsible for the discriminability of ethanol. The possible involvement of dopaminergic systems is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428115
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome (1976)
    Springer
    Psychopharmacology 49 (1976), S. 191-195 
    Details
    ISSN: 1432-2072
    Keywords: Pilocarpine ; Atropine ; Dexetimide ; Methylscopolamine ; Morphine addiction ; Narcotic withdrawal ; Aggression ; Wet shakes ; Diarrhea ; Dopamine ; Acetylcholine interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both ‘wet-dog’ like body shakes and aggression but it increased diarrhea and weight loss. Pretreatment with atropine blocked all of the effects of pilocarpine on withdrawal signs. Methylscopolamine pretreatment blocked only diarrhea. The administration of atropine or dexetimide produced no significant effect on any of the withdrawal signs. These results indicate a role for central cholinergic mechanism in narcotic withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427289
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  • 3
    Electronic Resource
    Electronic Resource
    Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training (1990)
    Springer
    Psychopharmacology 102 (1990), S. 221-226 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Norfenfluramine ; Amphetamine ; Pentobarbital ; Session-to-criterion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245925
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  • 4
    Electronic Resource
    Electronic Resource
    Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats (1975)
    Springer
    Psychopharmacology 42 (1975), S. 185-193 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Dopamine ; Haloperidol ; State-Dependent Behavior ; Apomorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-Β-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas α- and Β-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429551
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  • 5
    Electronic Resource
    Electronic Resource
    Rats become acutely tolerant to cathine after amphetamine or cathinone administration (1990)
    Springer
    Psychopharmacology 101 (1990), S. 126-131 
    Details
    ISSN: 1432-2072
    Keywords: Cathinone ; Amphetamine ; Cathine ; Drug discrimination ; Dopamine ; CGS 10746B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kgd-amphetamine or 0.8 mg/kgl-cathinone to generalize to 2.4–6.0 mg/kg of the active cathinone metabolited-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n=6) trained with cathinone (ED50=3.03 mg/kg) and in rats (n=8) trained with amphetamine (ED50=2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253729
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  • 6
    Electronic Resource
    Electronic Resource
    1H-NMR-Spektroskopische Isomerenzuordnung bei Cyclisierungs-Reaktionen an Benzo-kondensierten N-HeterocyclenHerrn Prof. Dr. Dr. h. c. mult. Alfred Rieche zum 80. Geburtstag gewidmet (1982)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 324 (1982), S. 569-574 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H-NMR Spectroscopic Assignments of Isomeres to Cyclization Reactions of Benzo-condensed N-HeterocyclesCyclic N-acyl benzazoles show downfield shifts of the aromatic Ha proton at the 1H-n.m.r. spectrum from 0.5 to 1.95 ppm which allows an assignment of possible isomeres and in some cases statements about the tautomerism. The ΔδHa values of 40 different azolo-, azino-, and azepino condensed benzimidazoles are given.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19823240411
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  • 7
    Electronic Resource
    Electronic Resource
    M. Regitz, u. Mitarb. von G. Mass und W. Illger, Diazoalkane-Eigenschaften und Synthesen. 1. Aufl. VIII, 339 S. 5 Abb., 53 Tab., Georg Thieme Verlag, Stuttgart 1997. geb., 148, - DM (1978)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 320 (1978), S. 877-877 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19783200522
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  • 8
    Electronic Resource
    Electronic Resource
    Cyansäureester. 32. Einfache Synthesen für Amino-aroxy-1,3,5-triazine (1981)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 323 (1981), S. 694-699 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cyanic Acid Ester. 32. Simple Methods for the Preparation of Amino-aroxy-1,3,5-triazines
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19813230425
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Struktur neuartiger ThiatriazinsystemeStereochemische Untersuchungen heterocyclischer Verbindungen. XVII [1]. (1986)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 328 (1986), S. 199-204 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Structure of New Systems of ThiatriazinesDepending on the nucleophilicity of exocyclic nitrogen in 2-guanidino-benzimidazole-1-carbimidic esters and 1-carbamides cyclization with N-sulfinyl amines leads to new 3-amino-1λ4, 2,4,6-thiatriazino[2,3-a]benzimidazole-1-oxide-5-carbimidic esters (3), 1-oxide-5-carbamides (5) and 3-(4-chlorphenylamino)-1-toluene-sulfonylimino-1λ4,2,4,6-thiatriazino[2,3-a]benzimidazole-5-carbimidic ester (7).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19863280208
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  • 10
    Electronic Resource
    Electronic Resource
    H. Hulpke, H. A. Koch, R. Wagner (Hrsg.), Römpp Lexikon Umwelt. 856 S., Georg Thieme Verlag, Stuttgart - New York 1993, DM 298,-. ISBN 3-13-736501-5 (1994)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 336 (1994), S. 283-284 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19943360323
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