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  • Chemistry  (9)
  • Eisenkomplexe  (1)
  • Gene therapy  (1)
  • Key words:Avascular area – Giant loop – Nailfold capillary microscopy – Wegener’s granulomatosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomedical science 3 (1996), S. 365-378 
    ISSN: 1423-0127
    Keywords: Retroviral vectors ; Gene therapy ; Stem cells ; Transcription ; Silence ; Inactivation ; Integration site ; Position effects ; Methylation ; Primer-binding site
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Although retroviral vector systems have been found to efficiently transduce a variety of cell types in vitro, the use of vectors based on murine leukemia virus in preclinical models of somatic gene therapy has led to the identification of transcriptional silencing in vivo as an important problem. Extinction of long-term vector expression has been observed after implantation of transduced hematopoietic cells as well as fibroblasts, myoblasts and hepatocytes. Here we review the influence of vector structure, integration site and cell type on transcriptional silencing. While down-regulation of proviral transcription is known from a number of cellular and animal models, major insight has been gained from studies in the germ line and embryonal cells of the mouse. Key elements for the transfer and expression of retroviral vectors, such as the viral transcriptional enhancer and the binding site for the tRNA primer for reverse transcription may have a major influence on transcriptional silencing. Alterations of these elements of the vector backbone as well as the use of internal promoter elements from housekeeping genes may contribute to reduce transcriptional silencing. The use of cell culture and animal models in the testing and improvement of vector design is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 261 (1968), S. 225-238 
    ISSN: 1432-1912
    Keywords: Iron Deficiency ; Iron Absorption ; Iron Complexes ; Rat ; Eisenmangel ; Eisen-Resorption ; Eisenkomplexe ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Retention von freiem und komplexgebundenem 59Fe-Eisen wurde 6 Tage nach Verabreichung mit der Schlundsonde bei normalen und anämischen Ratten in einer Ganztiermeßanlage bestimmt. 2. Anämische Ratten nahmen fünfmal mehr Eisen auf als normale Tiere, wenn ionisiertes Eisen angeboten wurde. Alle geprüften Komplexbildner vermindern die gesteigerte Eisen-Retention anämischer Ratten. Bezogen auf die Werte der anämischen Gruppe (=100%) wurde die Retention durch EDTA um 87%, durch Citronensäure um 40%, durch Ascorbinsäure um 32% und durch Nicotinhydroxamsäure um 31% herabgesetzt. 3. In Gegenwart von Komplexbildnern ist die Eisen-Retention anämischer Tiere bei Citronensäure 8,7, von EDTA 6,3, von Nicotinhydroxamsäure 3,7 und von Ascorbinsäure 2,7 mal höher als bei normalen.
    Notes: Summary 1. In normal and anemic rats, the retention of free and complex-bound 59Fe-iron was measured with a whole body counter 6 days after its oral administration. 2. If the iron is administered in the ionic form to iron-deficient rats they show a retention of iron 5 times greater than that of normal animals. The increased iron retention of anemic rats is diminished by all complexing agents tested. EDTA reduced it by 87%, citric acid by 40%, ascorbic acid by 32% and nicotine hydroxamic acid by 31%. 3. When the iron is combined with citric acid its retention by iron-deficient rats was 8.7 times increased in comparison to normal rats, with EDTA 6.3 times, with nicotine hydroxamic acid 3.7 and with ascorbic acid 2.7 times.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 19 (2000), S. 86-88 
    ISSN: 1434-9949
    Keywords: Key words:Avascular area – Giant loop – Nailfold capillary microscopy – Wegener’s granulomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Over the past 25 years, nailfold capillary microscopy (NCM) has gained diagnostic value in the field of rheumatology based on descriptive data from patients with distinct connective tissue diseases (CTD). We prospectively analysed NCM findings from 116 patients selected for NCM by one of the following indications: (1) suspected diffuse or limited scleroderma or dermatomyositis, (2) evaluation of Raynaud’s phenomenon (RP) or (3) suspected small-vessel vasculitis. Nailfold haemorrhages, and enlarged and tortuous nailfold capillaries (‘lupus pattern’) were found to comparable degrees in patients with CTD and primary RP. Only giant loops, bushy capillaries and avascular areas indicated CTD; 92% of patients with Wegener’s granulomatosis (WG) had avascular areas. From all nailfold capillary abnormalities, only bushy capillaries, giant loops and avascular areas support a suspected CTD. A lupus-like pattern is not diagnostic. Avascular areas are a typical abnormality in patients with WG, for which NCM findings have not been described previously.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 10 (1959), S. 151-152 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Corrosion Testing of Paints with the Aid of AerosolsIt is well known that opinions differ considerably about the value and usefulness of accelerated tests. On the other hand, it has been proved that the use of genuine aerosols for the corrosion testing of protective paints offers advantages as the testing technique is derived from the salt spray test. Spraying is not carried out by means of jets bat with the aid of suitably constructed aerosol as is used, for instance, in air conditioning. A 0,05 % solution of NaCl with a CO2 addition of 1 litre/hour is recommended as test medium. The corrosion test can be intensified by adding aggressive gases like CO2, HCl, NH3 and SO2.
    Notes: Bekanntlich gehen die Ansichten über Wert und Zweckmäßigkeit von Kurzzeitprüfungen stark auseinander. Dagegen ist erwiesen, daß die Verwendung echter Aerosole für die Korrosionsprüfung von Schutzanstrichen Vorteile bietet, wobei das Prüfverfahren den Methoden des Salzsprühtestes entstammt. Hierbei wird von einer Versprühung mit Düsen abgesehen und ein entsprechend konstruierter Aerosolapparat verwendet, wie er z. B. für die Raumlufterzeugung verwendet wird. Als Prüfmittel wird eine 0,05%-ige NaCl-Lösung mit einem CO2-Zusatz von 1 l/h empfohlen. Durch aggressive Gase wie CO2, HCl, SO2, NH3 läßt sich die Korrosionsprüfung verschärfen.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 397-398 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 12 (1961), S. 202-203 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 37 (1986), S. 63-64 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 155-156 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 40 (1989), S. 418-419 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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