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Gastroesophageal reflux in neurologically impaired children: partial or total fundoplication? (1998)

Ceriati, E. ; Guarino, N. ; Zaccara, A. ; [et al.]

Springer

Langenbeck's archives of surgery 383 (1998), S. 317-319

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ISSN: 1435-2451

Keywords: Key words Gastroesophageal reflux ; Neurologically impaired children ; Fundoplication ; Thal ; Nissen ; Gastrostomy ; Pyloroplasty

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Background: It is difficult to give guidelines when approaching gastroesophageal disease in neurologically impaired children. Indication for surgery has been increasing over recent years, but there is no consensus on the surgical technique of choice. Nothing has been written specifically comparing the results of different procedures in these patients, so far. Study design: We retrospectively compare the short- and long-term results of two different types of fundoplication in a series of children operated on for documented gastroesophageal reflux disease at our institution. Results: One group (group A) of 27 patients, operated on between 1977 and 1993, underwent Nissen fundoplication, the other (group B), formed of 20 patients all of whom were operated on between 1993 and 1995, underwent Thal fundoplication. We compared the results in terms of positive outcome (recovery) and negative outcome (minor and major complication), computing the relative odds of group A versus group B in terms of risk of complication, and we compared the mean operative time and the length of hospital stay by means of a student's t-test analysis. Conclusions: Our results show that there is no statistical difference between the two procedures in terms of relative risk of complication and success rate. The duration of surgery and hospital stay were significantly shorter in group B. The Thal procedure can, therefore, be proposed as first choice in the management of these patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004230050139

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Raman and infrared spectroscopic study of the molecular characterization of the biocompatibility of prosthetic biomaterials (1994)

Bertoluzza, A. ; Fagnano, C. ; Tinti, A. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Journal of Raman Spectroscopy 25 (1994), S. 109-114

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ISSN: 0377-0486

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Raman spectra were obtained directly in a non-destructive and non-invasive way from the biomaterials PMMA [poly(methyl methacrylate)], HDPE (high-density polyethylene), α-Al2O3 (alumina) and HA (hydroxyapatite) constituting the components (bone cement, acetabular cup, ball and stem coated with ceramic) of a hip prosthesis. The aim was to give an objective contribution at a molecular level to predict their biocompatibility. In particular, Raman spectra of explanted PMMA bone cements do not show the 1640 cm-1 band due to the stretching mode of C=C unsaturated centres. Moreover, conformational changes of PMMA following the implant appear in the spectra in the range 1100-500 cm-1, where conformational marker bands at 985, 968, 601 and 565 cm-1 are present. The limited number of HDPE explanted acetabular cups did not allow unequivocal Raman results to be obtained by means of band deconvolution in the region between 1500 and 1000 cm-1, regarding the changes in the crystalline, amorphous and interfacial contents of the acetabular cup surfaces following the implant. α-Al2O3 proved to be a ceramic with good biocompatibility as a biomaterial constituting a hip prosthesis. As regards the stem coating, Raman and Fourier transform IR spectra of HA pre-coating and HA coating on metal implants show spectroscopic modifications due to structural and chemical changes with formation of other calcium phosphates. The development of new bioactive coatings containing precursors of bone growth and able to promote osteogenesis is outlined.

Additional Material: 7 Ill.